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A surge in COVID-19 cases is further straining the already-depleted supply of prescription drugs in the U.S., according to researchers and doctors at the University of Minnesota."The supply lines are really stressed and stretched," said Dr. Stephen Schondelmeyer, a co-principal investigator for the Resilient Drug Supply Project at the University of Minnesota.Schondelmeyer's work focuses on critical drugs and their supply chains. He tracks the supply chain process for every drug on the marketplace — more than 100,000 in total.Most of the prescription drugs used by Americans are made outside of the country — meaning the U.S. is reliant on foreign companies to manufacture the drug and shipping companies to deliver them safely."We're identifying where it comes from — the first thing you need to know is about 70% of all the drugs that come into the U.S. marketplace are made outside of the US.," Schondelmeyer said.He and his team want to predict and identify when and where there will be failures in the system. Right now, the U.S. has a "fail and fix" system — and right now, there are some critical breakdowns in the supply chain."Seventy-five percent of the COVID-19 drugs are currently in shortage," Schondelmeyer said. "That means three-fourths of the drugs we're using for COVID-19 were already in shortage, and that's before we had this last surge we're seeing.""We should, as a matter of national policy, have a map like we're building of the global drug supply from the beginning all the way until the drug reaches the patient," Schondelmeyer said.But it's not just COVID-19 drugs that are in short supply. Dr. Beth Thielen, an assistant professor of pediatrics at the University of Minnesota Medical School and an infectious disease physician, says even some routine drugs are hard to come by."As a physician working in the hospital — the University of Minnesota — we're a big urban center and yet we're regularly dealing with this issue of shortages in routine things like antibiotics," Thielen said. "It's very concerning to think about the supply chain breaking down and seeing drugs not available in pharmacies or the hospital."Doctors say COVID-19 has unmasked a problem that's been a concern for decades. The pharmaceutical supply chain is complicated and dependent on other countries — and there are supply and demand dilemmas."Start the conversation now with your healthcare provider," Thielen said. "There might be some within class substitutions of medicines, so a drug that is related may not be the exact same drug but might fulfill the same purpose."Schondelmeyer adds that anyone with a regular prescription should ask their doctor about getting a 90-day supply of essential drugs — but adds that there's no reason to hoard medication."We shouldn't panic. We shouldn't treat drugs like we did toilet paper and stock up on so much that we're totally out — and that's an example of what can happen when there's rumors of shortages," Schondelmeyer said. "People act out of fear, and they hoard more than they really need."In the meantime, Schondelmeyer is pushing for a national stockpile of critical medications, so that the U.S. is covered should there be a complete breakdown in the supply chain. 3236

A North Texas woman took her battle against breast cancer public, allowing the world a front row seat in the operating room while doctors perform her lumpectomy.Before heading to the hospital today, DeSoto resident Sonia Johnson spent a lot of quiet time with her family. But this morning the 50-year-old will be seen by the world as she undergoes breast cancer surgery live on Facebook.It was last December when, during a routine visit to the doctor, Johnson found out she had a tumor on her breast. It was in that moment that she became determined to use faith and positivity to beat a disease that affects one in eight women.“It’s an emotional journey, but you can’t sit,” she said. “You’ve got to be mentally ready to walk this journey. It’s a fight, it’s a fight all the way.”Johnson found she’s not alone in her fight and has gotten scores of supportive messages from breast cancer survivors — forming a sort of sisterhood. She says sharing her journey on Facebook is one way she can help others fighting the same battle.Breast surgical oncologist Allison DiPasquale, MD, will be performing the surgery. She spoke about her admiration for Johnson when talking with CBS 11 News. “This patient is courageous, she’s amazing. She’s putting her body out there for people to say, ‘Wow, I’m going to go get my mammogram and I’m going to make sure I don’t have cancer.’”Johnson said she hopes that by sharing her experience online others will get a better understanding about one of the breast cancer treatments available.“Other people paid it forward before me and now I’m pushing it and paying it forward for somebody else,” she said.During Johnson’s procedure, doctors will go through her armpit to remove her lymph nodes and cancer through the same incision and when the surgical gloves and gowns are gone Johnson plans to join that sisterhood of breast cancer survivors.“I will be able to say ‘I had cancer’. Right now I say I have cancer. Tomorrow [it will be] I ‘had’ cancer.”Breast surgeons and radiation oncologists will be in the operating room during Johnson’s lumpectomy to answer questions from Facebook users in real time. 2142

A rare white tiger has mauled to death its keeper in a zoo in southern Japan, zoo official Takuro Nakazako told CNN.Police are investigating the incident after 40-year old Akira Furusho was found unconscious and covered in blood in the tiger enclosure at the Hirakawa Zoo, Kagoshima on Monday.The tiger named "Riku," one of four at the zoo, was tranquilized after the attack but was not put down because Furusho's family did not want it killed.White tigers are a genetic variant of the more common orange-and-black Bengal tiger but they have black stripes and white fur.The zoo was open as normal on Tuesday but the white tiger observation zone was restricted "as police continued to investigate the case," AFP reported.Riku, who was born at the zoo, is about 1.8 meters in length and weigh 374 pounds, AFP said. 820

A top Republican official in the area President Donald Trump is visiting Tuesday is asking him to wear a mask.The president held a campaign rally event inside an airport hangar in Winston-Salem. The campaign has said masks, hand sanitizer and temperature checks will be provided for attendees.Dave Plyler, the Republican chairman of the Forsyth County Board of Commissioners, told local media he believes Trump should wear a mask while visiting."It's been ordered by the governor," Plyler said of the state's face-covering mandate. "When in Rome, do as the Romans do. When in North Carolina, do as the governor says."Trump took the stage Tuesday evening without a mask on. While some in attendance, especially those seated directly behind Trump, wore masks, the majority did not, according to photos submitted by the Associated Press.North Carolina Governor Roy Cooper’s mask mandate is still in effect. Cooper is a democrat."He (Trump) is a citizen of the United States, but he is also a guest in our county," Plyler told the Winston-Salem Journal. "Without a mask, he could get sick, and he could blame the governor."Plyler is a supporter of the president and is pleased he is making the trip to Winston-Salem. However, he believes if Trump wore a mask, it would set the right example for other people."You know what would be neat? If before he got off the plane if he gave everybody a box of Make America Great Again masks," Plyler told CNN.The president has encouraged wearing masks and keeping socially distant during the pandemic. However, he is rarely seen in one in public.He has worn a mask on a few occasions in public, including during a visit in July to Walter Reed National Military Medical Center.North Carolina reported just over 1,000 new coronavirus cases on Monday. The state has reported a total of around 180,000 cases and 2,930 deaths. Forsyth county, where Winston-Salem is located, has reported 6,457 cases and 82 deaths from coronavirus. 1969

A top official in the Coast Guard has tested positive for COVID-19, according to CNN and NBC News.Admiral Charles Ray, the Vice Commandant of the Coast Guard, tested positive for COVID-19 over the weekend after experiencing mild symptoms.ABC News reports that all members of the Joint Chiefs of Staff, are self-isolating following Ray's positive test result. CNN also reports that Chairman Gen. Mark Milley is among those self-isolating.Ray's infection is just the latest in an outbreak of COVID-19 in the highest levels of the U.S. government. President Donald Trump spent the weekend in the hospital but returned to the White House Monday despite not being "out of the woods," according to his doctors. First lady Melania Trump, White House Press Secretary Kayleigh McEnany, White House advisor Hope Hicks, Sen. Thom Tillis, R-North Carolina, and Sen. Mike Lee, R-Utah, have all contracted COVID-19 in recent days. 924

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