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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

Comedian Jimmy Fallon announced on Sunday that tapings for "The Tonight Show" for the coming week have been canceled due to his mother's death. Fallon had previously canceled Friday's taping at the last minute due to a family matter. On Saturday, Fallon's mother Gloria Fallon died at the age of 68. “Jimmy Fallon’s mother, Gloria, died peacefully on Saturday," a spokesperson for Fallon told NBC News in a statement. "Jimmy was at his mother’s bedside, along with her loved ones, when she passed away at NYU Langone Medical Center in NYC. Our prayers go out to Jimmy and his family as they go through this tough time.”Other comedians, including fellow late night competitor Stephen Colbert, offered condolences to Fallon. "Mom is the first audience and the best. Remembering Jimmy Fallon and his family in our prayers today," Colbert tweeted. Fallon opted to cancel tapings this week instead of employing guest hosts. Last week, ABC late night host Jimmy Kimmel had fill-in guest hosts while he was out due to his son's heart surgery.  1079

COPENHAGEN, Denmark (AP) — Authorities say the number of passengers on a Norwegian cruise ship who have tested positive for the coronavirus has reached 43.The outbreak on the MS Roald Amundsen has raised new questions about safety on cruise ships during the pandemic even as the industry is pressing to resume sailings after shutting down in March.The ship’s owner, Hurtigruten, has halted all trips and Norway closed its ports to cruise ships for two weeks.Since the cruise line often acts like a local ferry, traveling from port to port along Norway’s west coast, some passengers may have spread the virus to local communities. 637

COLUMBIA, S.C. — Rapper Kanye West used part of his first event since declaring himself a presidential candidate to rant against historical figure Harriet Tubman. West said the Underground Railroad conductor “never actually freed the slaves, she just had them work for other white people." West's comments drew shouts of opposition from some in the crowd gathered Sunday in North Charleston, South Carolina. His appearance was marked by a lengthy monologue touching on topics from abortion and religion to international trade and licensing deals. At one point he said he and wife Kim Kardashian had considered terminating their first pregnancy. Several sources report West became tearful during the speech Sunday, explaining how a message from God changed his mind and he got a call from Kardashian saying they were going to have the baby. North West was born in 2013. Whether West is actually seeking the nation’s highest office remains a question. Last week he met the requirements to appear on Oklahoma's presidential ballot. An Oklahoma elections spokeswoman says a West representative submitted paperwork and the ,000 filing fee Wednesday for the state's Nov. 3 ballot. A West adviser told New York Magazine that West was out, but TMZ reports his campaign filed with the Federal Election Commission. West has already missed the deadline to qualify for the ballot in several states. 1397

CLEVELAND — Sex toys, envelopes and craft supplies are among the products Ohio workers say their companies continue to make or distribute under the protection of being so-called "essential employers" as most businesses across the state have shut down during the Coronavirus outbreak.Workers are raising concerns about their health and safety and remain skeptical whether employers are finding loopholes during Ohio's stay at home order issued by Gov. DeWine requiring non-essential businesses to close as of Monday night."I'm afraid of being fired if I don't come to work," said one employee at AmeriMark, a Cleveland-based direct marketer of women's apparel, shoes, cosmetics and health related merchandise --including more than 30 sex toys included in its "health living essentials."The company also distributes wrist blood pressure monitors, pulse oximeters, glucose monitors and wheelchairs. The Ohio Department of Health's "Stay at Home Order" specifically includes "distributors of medical equipment."In a recorded message to its employees, workers are being told, "We are happy to report AmeriMark will remain in operation during this period...in this unparalleled time, we are excited to serve AmeriMark customers."The company has not yet responded to our inquiry."My concern is that there are a lot of elderly women working here," said another worker concerned about passing the virus from person to person.The State's StanceDuring Tuesday's news conference, Lt. Governor Jon Husted acknowledged confusion over the definition of an "essential business" and referred employers to Ohio's coronavirus website."It's written in plain language, we ask you to follow the language and use your best judgment," said Husted. "Please don't call law enforcement and ask them to interpret it for you."Lt. Governor Jon Husted"You don’t need a letter, certification or clearance. You do need to have a rationale about how the order applies to you," said Husted. "If you have a question – read it – come to your justification and have it prepared in case you’re asked."He said if businesses are not following the order they will eventually be "called on it by an employee or a competitor.""Please don't let it come to that," he said.More concerned workersAnother Cleveland company, Cenveo, is raising questions among workers who produce envelopes--including some used by the U.S. Postal Service."Why are we essential?" asks one employee. "We make one type of envelope for the postal service--I'm afraid of losing my job if I don't show up."A news release issued by by the company on March 17, said "precautionary measures have been put in place at both our office and manufacturing facilities as we continue to operate in our regular course of business."Cenveo, based in Stamford, Connecticut, identifies itself as a "world leader in the management of print and related offerings" and has not yet responded to our inquiry.Essential Crafting?Even craft stores, like Michaels and Joann Fabric and Craft Stores continue to remain open despite health concerns among employees."Crafting is non-essential," said one Michaels employee. "Are they above the rules?"A company release addressing the COVID-19 outbreak said "we are taking precautionary measures to ensure our corporate offices, stores, distribution centers and other facilities minimize the risk."In a message to Joann customers, the company said "now more than ever it is important to safely provide what these Americans need to support their livelihood, mental wellness and community giving."Among those items, the company is encouraging customers to help make "protective non-surgical masks and gowns during this critical time."The company adds that it is "taking action to ensure we are protecting our facilities, customers and teams across the nation."Ask Sherwin WilliamsA worker at a Sherwin Williams paint plant in Massillon asks, "Since when is bodyfiller and paint essential? It shows they don't care about their employees at all."The company responded saying "the health and safety of our customers and employees during this pubic health emergency is of utmost concern" adding it has closed the sales floors at its paint stores and is allowing customers to shop online instead.Regarding its manufacturing facilities, the company says: "We serve a critical role supplying product customers who support health care facilities, manufacturing plants and other infrastructure."They are among just a handful of Ohio workers concerned over their health and safety at work--many worried they will be fired if they fail to show up.From a company manufacturing aluminum parts to workers at a food distribution center--all remain concerned over how companies are remaining open and possibly jeopardizing their health."Keeping open is just a way for them to get money," concludes one worker.Copyright 2020 Scripps Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. 4977