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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

BEIJING, Feb. 15 (Xinhua) -- Chinese Vice Premier Wang Qishan told a U.S. business delegation Tuesday that China would create a sound environment for business cooperation between the two countries.Praising the contribution of U.S. businesses to the sound development of China-U.S. relations, Wang said more exchanges between business people from the two countries would help promote bilateral trade cooperation.Chinese Vice Premier Wang Qishan (C front) poses for a group photo with members of a visiting U.S. business delegation headed by John Mack, chairman of Morgan Stanley, in Beijing, capital of China, Feb. 15, 2011. Executive chairman of Morgan Stanley and chief delegate John Mack said the U.S. business community would increase exchanges and cooperation with Chinese counterparts and play a positive role in the sound development of bilateral relations.The delegation, composed of the heads of many major U.S. companies, including General Motors, is visiting China from Feb. 13 to 16 for unofficial exchanges with Chinese businesses, including China National Offshore Oil Corporation and CITIC Group, according to the China Council for the Promotion of International Trade.

SAN FRANCISCO, May 10 (Xinhua) -- Microsoft Corp. on Monday said it will buy Internet communications company Skype for 8.5 billion U.S. dollars in cash, a bold move for the software giant to explore new business opportunities."Skype is a phenomenal service that is loved by millions of people around the world," Microsoft CEO Steve Ballmer said in a statement."Together we will create the future of real-time communications so people can easily stay connected to family, friends, clients and colleagues anywhere in the world," he added.Microsoft said it has agreed to buy Skype from the investor group led by Silver Lake, and the deal has been approved by the boards of directors of both companies.Skype will become a new business division within Microsoft, and Skype CEO Tony Bates will assume the title of president of the Microsoft Skype Division, reporting directly to Ballmer.The Skype deal ranks one of the biggest purchase in the 36-year history of Microsoft, which is struggling to compete in the fields of Internet and mobile phones beyond its dominance on personal computer software market.Founded in 2003 and based in Luxembourg, Skype offers a software application that allows users to make free or cheap phone calls and chats over the Internet with additional features including instant messaging and video conferencing.Numbers showed that Skype's 170 million connected users made over 207 billion minutes of voice and video conversations in 2010.Skype was acquired by eBay in September 2005, and then acquired by an investment group led by Silver Lake in November 2009.In a press release announcing the acquisition, Microsoft noted that the deal will increase the accessibility of real-time video and voice communications, generating significant new business and revenue opportunities, and enhancing its existing offerings of real-time communications products and services.Microsoft said Skype will support its devices like Xbox and Kinect, Windows Phone and a wide array of Windows devices, and it will continue to invest in and support Skype clients on non-Microsoft platforms.The acquisition is expected to obtain all required regulatory clearances within this calendar year, Microsoft said.

WASHINGTON, May 20 (Xinhua) -- Two U.S. astronauts conducted the first of four spacewalks for space shuttle Endeavour's STS-134 mission on Friday morning, the U.S. National Aeronautics and Space Administration (NASA) said.According to the U.S. space agency, Endeavour's mission specialists Andrew Feustel and Greg Chamitoff completed the six-hour, 19-minute spacewalk at 9:29 a.m. EDT (1329 GMT). They successfully installed antennas for the External Wireless Communication system, routing cables, setting up the antenna, installing handrails, and connecting power cables.Because of a carbon dioxide sensor failure in Chamitoff's spacesuit, flight controllers limited his spacewalk time to about six hours 20 minutes, 10 minutes less than the planned six hours and 30 minutes. There was no indication his suit's carbon dioxide levels would rise. However, they deferred tasks to remove a micrometeoroid debris shield to access and attach some of the connection points.This was the 245th spacewalk conducted by U.S. astronauts. It was Feustel's fourth spacewalk for a total time of 27 hours and 17 minutes, and Chamitoff's first.Endeavour lifted off on Monday morning from Kennedy Space Center in Florida, to deliver to the International Space Station a 2-billion-dollar, multinational particle detector known as the Alpha Magnetic Spectrometer (AMS).AMS, a particle physics detector, is designed to search for various types of unusual matter by measuring cosmic rays. Its experiments are designed to help researchers study the formation of the universe and search for evidence of dark matter, strange matter and antimatter.

JOHANNESBURG, March 8 (Xinhua) -- In order to combat piracy and to improve maritime safety, South African authorities have begun using a sophisticated navigation satellite system, it was announced on Tuesday.Piracy, especially by Somalis, has been increasing along Africa east coast in recent years. The South African Press Association (SAPA) reported on Tuesday that Karl Otto, head of the South African Maritime Safety Authority (SAMSA) announced the surveillance tool at a conference in Durban.Called Long Range Identification and Tracking (LRIT), the system monitors and tracks vessels in waters south of the equator.Otto said the introduction of the LRIT followed concerns over the safety of seafarers, the safety standards of ships within South African waters.Otto said there were high levels of cargo at risk, such as fuels and oils.He said reasons for installing the system included the number of shipwrecks along the South African coast, and the threat of pollution of the marine environment by ships."It also serves as a mechanism to prevent piracy."Otto said the satellite system has the capacity to identify and track vessels up to 1,000 nautical miles (1,850 km) from the South African coastline as well as South African-flagged vessels anywhere in the world."This is a revolutionary development in the security of our seas," he said.SAMSA was determined to protect South Africa's seafarers, its coastline and the marine environment, Otto said.

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