濮阳东方医院男科看早泄价格合理(濮阳市东方医院口碑) (今日更新中)

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) — Mission Valley's Gordon Biersch restaurant may be closing, but the brewery location will live on under a new local eatery.Puesto will take over the location of the well-known restaurant after it closes in July, according to the company. The Mission Center Road spot will be the Mexican restaurant's third location.Gordon Biersch is set to leave Mission Valley on July 16, though no reason was immediately given for the closure, according to paperwork filed by the company. RELATED: Uber Eats to test drone delivery service in San DiegoPuesto will reopen the on-site brewery and try to retain as many of Gordon Biersch's staff as possible. The new restaurant plans to open in Fall 2019.The on-site brewery will give Puesto the opportunity to develop their own beer program, after collaborations with San Diego and Mexico breweries for years, in addition to its signature margaritas and cocktails.“The Puesto team has been doing cervecería collaborations for years now, working primarily with cervecerías in Mexico to create our own San Diego meets Mexico cervezas," Puesto co-owner Eric Adler said. "We’ve been looking for a space in San Diego for some time where we could develop our own cerveza program. This new space gives us the opportunity not only to brew, but continue bringing our innovative approach to authentic Mexican flavors to more of our hometown.”Puesto currently operates six restaurants around California, offering a variety of handmade tacos, bowls, and street food-style plates. 1525

SAN DIEGO (KGTV) — Local officials say a record number of San Diegans died of meth last year.According to the county's 2020 Meth Report Card, 546 San Diegans died from meth in 2019, 63 more than the previous record of 483 set in 2018.The County Medical Examiner's Office says people most impacted by meth are those 45 years of age or older, which represented 319 of the meth-related deaths. The ME says people in this age range tend to have chronic cardiovascular disease, which may have been from long-term meth use."There’s no sugarcoating it: Meth is destroying lives and families at a record pace here in San Diego County," said County Supervisor Dianne Jacob. "Local law enforcement and treatment services are on the front lines battling this scourge, but clearly we need to do even more as a region."While San Diego was once considered the "Meth Capital of the World," little is made locally today and most of it is being transported into the county from Mexico, according to the report. The DEA says that meth seizures at U.S.-Mexico ports of entry nearly doubled in 2019 compared to 2018.People who want to anonymously report meth or drug activity are asked to call the Meth Hotline at 877-NO-2-METH or visit www.no2meth.org. Substance use treatment resources are also available from the county’s access and crisis line at 888-724-7240 or 2-1-1. 1361

SAN DIEGO (KGTV) — Merritte Powell hired six new people once his downtown restaurant got the green light to serve indoors again.But now, those workers could be in for some bad news. The three or four shifts they thought they’d get each week at La Puerta could instead be reduced to one, if that.“The hardest part is just the emotions and the mental health of the people working in the industry,” Powell said.It’s because San Diego County is in danger of falling into the state’s most restrictive purple tier of coronavirus restrictions, which would ban restaurants from serving indoors. That would be the latest setback in the region's push to return to normal amid the outbreak.“It feels like they're just playing games with us at this point, and it's getting frustrating,” Powell said.The twists and turns are taking a big toll, not just on day-to-day operations, but also when it comes to hiring in the future.“You're not going to hire people back, you're being extremely cautious,” said Ray Major, SANDAG’s chief economist.Major said restaurant owners have it especially hard. Not only do they have to be concerned with whether they can break even, but also if a future move into a less restrictive tier would only be temporary."We're really going to have to get into the orange or the yellow tier, and we're going to have to be able to stay there, and businesses are going to have to have the confidence that we're not going to shut them down again before they start rehiring people," Major said.SANDAG says the region's jobless rate was 13.3%, with 226,000 unemployed workers as of Sept. 5. As for Powell, he said he certainly would not have hired six people if he knew more restrictions were on the way. 1718

SAN DIEGO (KGTV) — Lifeguards say two people were rescued from a trail in the Blacks Beach area on Sunday in separate incidents.The first involved a woman who injured her ankle, according to San Diego Fire-Rescue. The woman was about half-way down before being injured. Lifeguards put her on a stretcher and used ropes to lower her down to the beach. She was taken by lifeguards to meet paramedics.The second occurred on the same trail, involving a woman suffering from heat exhaustion. She was unable to make it down the rest of the trail, requiring lifeguards to hoist her to the beach below to get her to paramedics.Lifeguards said with Labor Day weekend approaching and a heatwave expected next weekend, they are reminding visitors to local trails to know their limits, wear proper footwear for uneven beach terrain, and make sure they have plenty of water.Beach lifeguards say they don't expect to see crowds slow down anytime soon. 945

来源：资阳报