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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

LOS ANGELES, April 20 (Xinhua) -- Hundreds of homes were evacuated on Wednesday in Monument, U.S. state of Colorado after hydrochloric acid was leaking from a train car, authorities said.The leak was first reported around 1 a.m. local time when a southbound train spotted a vapor trail on a northbound train, the Denver Post reported.Authorities first ordered the evacuation of some 255 homes, and later expanded the evacuation to an additional 160 homes, according to the report.Schools in the area were closed due to the leaking, the report said.A specialized crew from Texas has been dispatched to the scene to transfer the hydrochloric acid leaking from the train car and is expected to finish the job in four or five hours, weather permitting, the report quoted Sgt. Mike Schaller of the El Paso County Sheriff's Office as saying.The leak is contained but hydrochloric acid is still leaking slowly from the tanker, which holds 25,000-30,000 gallons, Schaller said.He said police went door-to-door notifying residents of a subdivision adjacent to the railroad tracks to evacuate as a precaution.No injuries have been reported, he said, but residents have been warned that they may have to be out of their homes until Friday as hazardous material crews offload the acid to another container.The northbound train originated in Kansas and was en route to Denver at the time, the Denver Post said.It's not yet known how much hydrochloric acid leaked from the train car.Once the leak is sealed, crews will remove the hydrochloric acid from the damaged car to a new car that will likely continue into Denver, according to the report.Monument is a town of 3,230 residents 88 kilometers south of Denver.

BEIJING, March 15 (Xinhuanet) -- Chris Poole, the 22-year-old founder of 4Chan.org, criticized Facebook's approach and spoke up for online anonymity at South by Southwest Interactive in Austin, Texas, according to media reports Tuesday.Poole called out early in his keynote speech at the huge Austin tech event, referencing this Zuckerberg quote from David Kirkpatrick’s book "The Facebook Effect": "Having two identities for yourself is an example of a lack of integrity.""Anonymity is authenticity; it allows you to share in a completely unfiltered way," Poole countered. "It allows you to play in ways, you might not if people knew who you are.”Losing the ability to be anonymous on the Internet is, "a kind of loss of the innocence of youth," Poole said, crediting 4chan’s culture-infiltrating creativity to anonymity. "You can’t make mistakes,“ and then leave them behind, like the olds did pre-Facebook. If your mistakes ever made it to the Internet, they’re with you wherever you go.Poole — known by the 4chan handle "moot" — was to promote his new meme-generating venture, Canvas, still in beta testing.Launched for anime enthusiasts in 2003, 4chan is one of the most popular image-sharing bulletin boards on the Internet, with most of that traffic hitting 4chan’s notorious "random" image board, the /b/ board.

LOS ANGELES, April 29 (Xinhua) -- Clinical and teaching microbiology laboratories are linked with a nationwide salmonella outbreak in the United States that has killed one person and sickened dozens of others, health officials confirmed on Friday.Since August, about 73 people in 35 states have been sickened by salmonella bacteria, and some of those cases involve a strain of Salmonella typhimurium sold commercially to laboratories, officials from the Centers for Disease Control and Prevention (CDC) said in remarks published by msnbc.com.Illnesses have been tied to laboratories from Alaska to New York, with most reporting one or two cases. Five cases have been reported in Washington state and four in Minnesota.The first illness occurred late August and the most recent cases were reported March 8, according to the CDC.The patients include employees and students of the laboratories, as well as children in the homes of people who work or study at the labs.Patients ranged in age from less than one to 91, with a median age of 24, the CDC said.Cases that developed after March 19 may not yet be included in the total because of the lag time in assessing and reporting illness, said the report.CDC officials warned that bacteria used in the labs can be transmitted through contaminated lab coats, pens, notebooks, car keys and other items brought into the labs.The CDC is working with local and state health departments, the American Society for Microbiology and the Association of Public Health Laboratories to track the outbreak, the report said.Salmonella infections typically result in diarrhea, fever and abdominal cramps. They can be dangerous in very young children or people with compromised immune systems.

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