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Holidays will look different this year for many Americans, with dinners outside, social distancing, or passing on family gatherings altogether. But several companies developing rapid at-home COVID-19 tests are hopeful that won't be the case next year. The goal is to make inexpensive, easy-to-use COVID tests that can deliver results in minutes, just like a pregnancy test. "For people to feel comfortable to associate with friends or family, there needs to be a testing methodology ideally that can be performed at home," said Tony Lemmo, CEO of the manufacturing company BioDot.The company's technology is being used by over 70 manufacturers worldwide making COVID-19 antigen, antibody, and PCR tests. Their automated platforms dispense nanoliter/picoliter amounts of reagent onto the tests accurately and fast.Lemmo says just one of their systems can support the production of roughly 100 million COVID-19 tests per year, helping to make high-volume production possible.“We knew we were going to be called on by customers to manufacture more equipment to provide them the ability to manufacture more tests," said Lemmo. To meet customer demand, BioDot increased staffing and built a new facility, compressing production time from months to weeks. The FDA recently authorized the first rapid at-home test that can deliver results in 30 minutes, eliminating the need for a lab to test the sample. But the molecular single-use test will only be available to patients with a doctor's prescription who are suspected of being infected with COVID-19.Companies developing tests hope the FDA will soon authorize another at-home testing tool: the rapid antigen test.These inexpensive tests provide results within minutes, and companies developing them say millions could be sold without a doctor's referral.“From what we’re hearing, it’s really just a matter of possibly months before there’s at least sufficient data to be able to support an at-home use of a test like an antigen test," said Lemmo.Lemmo says if authorized by the FDA, manufacturers could make millions of these tests in a matter of months. But antigen tests are less accurate, and the FDA wants to ensure they'll be simple enough for people to use at home. There are also concerns over how the data will be reported to health authorities. “I think any at-home testing or massive rollout of a test into the communities needs to be done very carefully and with a lot of education around it," said Clinical Lab Director Melissa Miller. Dr. Miller is a professor of pathology and laboratory medicine at the University of North Carolina Chapel Hill and Medical Director for the Clinical Microbiology Lab for the Medical Center.She worries the inaccuracies of these tests could eventually lead the public to lose trust in all testing. “Even at 98 percent specificity, which is very, very high. That means you’re going to have a false positive two out of every 100. If you started testing a hundred million people, this is millions of people who have a false-positive test," said Dr. Miller. She says this could lead to healthy people isolating and missing work or school unnecessarily, and false-negative results could give people a false sense of security. “These rapid antigen tests were pushed out to skilled nursing facilities; this is a very high-risk patient population. This is actually where you want a very accurate test," said Dr. Miller. She says it’s unclear how well antigen tests detect the virus in asymptomatic patients but agrees more data is needed to figure that out.“It might make more sense for K-12 schools, or even college settings, where there’s less risk for a poor outcome if you have a false positive or a false negative," said Dr. Miller. But with a growing demand for convenient at-home testing, manufacturers are hopeful that in the months ahead, the FDA will soon open the door to new solutions. 3889

Grand Canyon’s entire men’s basketball team has been placed in quarantine after four players and two support staff members tested positive for COVID-19.All 14 players and two student managers are in quarantine at a designated on-campus residence hall for the next two weeks.Players began reporting for voluntary individual workouts last week and were placed in quarantine for 72 hours pending results of coronavirus tests and physicals. Four players who were asymptomatic tested positive at the end of the 72 hours and were placed in quarantine while contact tracing was conducted.Players who tested negative were placed in quarantine as a precaution and will be tested again. The two support staffers who tested positive will remain at home for two weeks. 764

HOLLISTER, Calif. (AP) — A magnitude-4.7 earthquake has struck a wilderness area of central California.The U.S. Geological Survey says the temblor occurred at 12:42 p.m. Tuesday and was centered about 16 miles (25 kilometers) southeast of Hollister. The quake occurred at a depth of 6 miles (9.6 kilometers).The epicenter area is in a rugged mountain range, with agricultural areas to the west.Late Monday, the San Francisco Bay Area was rattled by a magnitude 4.5 earthquake.That quake was center near Pleasant Hill, northeast of Oakland but was felt widely.More than 67,000 people posted to the U.S. Geological Survey's citizen reporting web page.Veteran seismologist Lucy Jones says the two quakes are too far apart to be related. 741

Health officials in Santa Clara County, California, say that they have traced 94 cases of COVID-19 to a youth basketball tournament that took place illegally at a nearby indoor sports complex last month.According to CNN, Courtside Basketball Center in Rocklin, California — located northwest of Sacramento — hosted a "Fall Fest" tournament on Nov. 7 and 8 that featured several teams and dozens of players and coaches.On Friday, The Mercury News reported that a total of 94 cases of COVID-19 — including 77 in Santa Clara County alone — could be traced back to the tournament.The Mercury News says the outbreak includes 39 "middle- and high school players," three coaches and 35 additional contacts."This outbreak is a troubling reminder that the widespread prevalence of COVID-19 in our community threatens all of us, and does not limit itself to geographic boundaries," Santa Clara County's assistant public health officer, Dr. Monika Roy, said in a statement.The California Department of Public Health said in a release that is has opened an "enforcement investigation" into the tournament's operator.CNN reported last month that the Courtside Basketball Center's website included a note that urged anyone who was in attendance for the tournament to get tested for the virus, "regardless of whether they have symptoms."As of last month, CNN reports that the complex had hoped to host four more basketball tournaments by the end of the year. The center's website now says it is "closed until further notice."Santa Clara County — which is located south of San Francisco and is home to the city of San Jose — has among the strictest COVID-19 restrictions in the country. The county has banned most contact sports at all levels — youth, college and professional — and the restrictions have forced the San Francisco 49ers to move two home games to Arizona."Public Health orders, directives, and guidance around contact sports and sporting events are in place for a reason. The risk of transmission in these settings can easily result in community spread that threatens the most vulnerable among us," Roy said. 2115

Heads (and eyes) up, skywatchers! The annual Perseid meteor shower is underway and will hit its peak this weekend.The meteor shower, so named because the meteors appear to come from the constellation Perseus, lasts for several weeks – from July 17 to Aug. 24 – but peak meteor activity will take place between about 4 p.m. ET on Sunday, Aug. 12 and 4 a.m. on Monday, Aug. 13, according to NASA.During the peak, one can expect to see as many as 60 or 70 meteors per hour.Night sky conditions should be great for meteor viewing: The peak coincides perfectly with the new moon, meaning the sky will be plenty dark and meteors will be easy to spot. Most meteor showers are best after midnight. 702

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