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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) -- It's survival of the fittest once again for gyms and fitness centers across the county as San Diego braces for stricter pandemic-related restrictions that go into effect Saturday.One gym preparing for the big shift is major chain 24 Hour Fitness. While members can't choose from their dozens of locations to workout, seven county locations will be open and offering outdoor equipment to members."We're committed to staying outdoors, staying safe, and the well-being of our members is the priority," said 24 Hour Fitness district manager John Amato.Amato told ABC 10News that member visits will be reservation based with 90-minute windows, minimized to 57 guests at a time.While many prepared for what's to come, others like gym owner Tom Green of Green Speed Training in Eastlake did the opposite. Instead of expanding his outdoor space for members, he doubled the square footage on the inside, even though guests won't be allowed to workout indoors until the county falls in a less restrictive tier."It's certainly risky, but I've always been kind of a risk taker and I go with my gut instinct, and if I feel good about it, I go for it," Green said.Since the COVID-19 pandemic began, Green said support from the Eastlake community along with members of his gym have helped keep things afloat and allowed him to upgrade indoor space."It's very supportive, and we have a lot of great clients who really support what we're doing,” said Green.Regardless, both gyms said they'll continue to be there for their clients no matter which tier San Diego slips into next."To get that one-hour workout in, and de-stress to stay healthy, that's what our goal is,” said Amato. 1691

SAN DIEGO (KGTV) - Kids and teens struggling with their mental health during the Coronavirus Pandemic and weeks of protests over racial injustice have a new way to cope.BlueShield CA has expanded its Blue Sky program, increasing funding to local mental health organizations and giving kids a platform to share tips on dealing with anxiety and depression."There's a greater need now than ever," says Blue Sky Program Manager Amanda Lasik. "There's a greater need to speak to youth voices and listen and learn from what's going on."According to the CDC, 7.1% of kids age 3-17 have been diagnosed with anxiety, and 3.2% of kids in the same age group have been diagnosed with depression. Experts believe those numbers will rise because of the pandemic and protests.As part of the expansion, Blue Sky partnered with DoSomething.org to launch the "New State of Mind" campaign. Kids send tips for coping to the website, which get published through emails, texts, and social media."The response has been overwhelming," says Lasik. "When we were originally planning this campaign, we thought it'd be great if we got about 17,000 tips. We've already received over 60,000."In addition to the "New State of Mind" effort, Blue Sky has provided 0,000 to 18 youth organizations in San Diego and Alameda county. The money has helped them adapt their services to the challenges of the past few months."It's been a quick transition, but these groups are now offering counseling online, doing arts programming online, and engaging young people online in different ways," says Lasik."We've also heard from the nonprofit community that they just need a little bit of operating support."The money is in addition to the million that BlueShield pledged as part of the Blue Sky initiative last December.RELATED: South Bay schools partner with insurance company to address student mental health challengesFor high school student Joel Castro, connecting with these programs has been empowering."It gives me hope," says Castro. "It's great to see other young people get very passionate about issues and wanting to fix them." 2111

SAN DIEGO (KGTV) - Interstate 15 Express Lane signs are being changed from white to green, with other improvements, at a cost of .5 million, the San Diego County Association of Governments said Thursday.A research effort determined that the existing signs could be difficult for drivers to read, and that information about toll rates and permission to use the lanes was unclear, according to SANDAG."There's quite a bit of confusion on the motorists part, trying to understand, can I actually get in there as a carpool or not?" said Ray Traynor, SANDAG's director of operations. "Having a system that's clear to the end users is vitally important so that the lanes operate effectively."A spokesman for Caltrans says research showed a green sign with white text was more difficult to read, with the amount of information on the sign. The I-15 Express Lanes stretch for 20 miles between SR-78 in Escondido and SR-163 in Kearny Mesa. There are more than 16 access points where drivers can move in or out of the lanes.WHAT WILL CHANGEThe upgraded signs were designed to address the concerns from I-15 commuters.Improvements include: 1153

SAN DIEGO (KGTV) -- Millennials are leaving San Diego in the thousands, according to a new report by Brookings. The new Census Bureau migration data reveal a post-recession shift in the migration of young adults and seniors. From 2007 to 2012, San Diego lost more than 7,400 people between the ages of 25 to 34 annually. From 2012 to 2017, the number dropped slightly to a little more than 7,000. RELATED: San Diego's median rent more than starting salaries for Class of 2019 483

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