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WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.

BEIJING, Dec. 28 (Xinhuanet) -- China started to run its own satellite positioning system, Beidou, on Tuesday as the country climbed the global tech ladder and challenged the monopoly of the West. Beidou, or Big Dipper, the domestic version of the US Global Positioning System (GPS), started providing navigation, positioning and timing data on a pilot basis to China and the neighboring area for free on Tuesday, Ran Chengqi, director of the China Satellite Navigation Office, said. The system, with 10 orbiting satellites, covers an area from Australia in the south to Russia in the north. Signals can reach the Xinjiang Uygur autonomous region in the west and the Pacific Ocean in the east, Ran said. With six more satellites to be launched next year, the system will cover a wider area and eventually the entire globe by 2020 with a constellation of 35 satellites, he said. The accuracy of the positioning service will also improve as more satellites orbit. During the trial run Beidou can offer positioning to within 25 meters but when the system is officially launched next year accuracy will be enhanced to within 10 meters, he said. With the system operational China is the third member of an elite group, along with the US and Russia, to develop a satellite navigation system. The US spent 20 years and more than billion on the GPS. Completed in 1994, the system has 24 navigation satellites and is widely used around the world. Beidou has its own unique features, Ran said. "It not only tells users where they are and what time it is but also allows users to tell others the information through short messages," Ran said, adding that this feature is being considered by other systems. Russia's Glonass system achieved a 24-satellite constellation in 1996 but succumbed to funding problems. The rebuilding of the Glonass system is almost finished and Russian media reported that the system resumed service earlier this month. The European Union and the European Space Agency are building the Galileo satellite navigation system. Japan and India also intend to build independent regional navigation systems. "Countries build their own systems because owning an independent satellite navigation system is important to economic development and national security," said Pang Zhihao, deputy editor-in-chief of the monthly publication Space International. There have long been concerns that the US might take its dominant GPS offline in certain international emergencies. Ran said that the Beidou system will be "helpful" to national defense. An "independent and controllable" satellite navigation system can guarantee national economic development as well as scientific and industrial strength, he said. China started to reduce its reliance on the GPS in 2000, when it sent an experimental pair of positioning satellites into orbit. But Ran stressed that Beidou is "built for the world", as the compatibility of various systems enhances reliability for users. "If you only use GPS there will be blind spots. But from demonstrations I saw recently, receivers that are compatible with Beidou will overcome these problems," he said. He encouraged enterprises at home and abroad to join the research and development of application terminals compatible with Beidou. The office put a test version of the system's Interface Control Document online on Tuesday, which is a technical document vital for the manufacturing and development of receivers and chips. The prospects for the country's satellite navigation industry look bright, experts said. Analysts estimated that around 2020 the industry's output will reach 0 billion globally, including 400 billion yuan ( billion) to 500 billion yuan from China. According to the 2011 Report on Application of Geosaptial Information in China released on Monday, the number of satellite navigation application terminals in China has grown from less than 100,000 in 2000 to more than 10 million in 2009. The number is expected to reach 340 million by 2015. An insider said a compatible receiver for car use costs 1,600 yuan to 3,000 yuan, higher than a GPS receiver. "Chips supporting both GPS and Beidou systems have been developed, and terminals have been produced. There are no technical hurdles for the industry," said Han Shaowei, CEO of Beijing-based Unicore Communications Inc, a major navigation chip and core component provider. Beidou application terminals have been put into use in vehicles, such as government cars in Guangdong province. Ran said that private terminal makers in Guangdong are testing their receivers on the road, and the products seem stable. "The price of the compatible terminals is expected to be slashed next year," he said.

SAN FRANCISCO, Nov. 1 (Xinhua) -- Apple announced on Tuesday that its latest iPhone 4S smartphone will be available in China's Hong Kong, South Korea and 13 additional countries next Friday.Customers will be able to pre-order iPhone 4S beginning this Friday, the Cupertino, California-based company said in a statement.The other 13 countries are Albania, Armenia, Bulgaria, El Salvador, Greece, Guatemala, Malta, Montenegro, New Zealand, Panama, Poland, Portugal and Romania.So far, some owners have been complaining about the shorter battery life on their new iPhone 4S handsets. Apple is reportedly investigating the issue and has not made official comments yet.The iPhone 4S looks the same as the previous iPhone 4 but has major hardware upgrade inside. Apple announced sales of more than four million units of iPhone 4S in the three days after its launch in the United States on Oct. 14.The iPhone 4S now is available in 29 countries and is expected to arrive in stores in more than 70 countries by the end of this year.

HELSINKI, Nov. 7 (Xinhua) -- A data leak was uncovered in Finland Saturday, in which personal details of around 16,000 people were uploaded onto a file-sharing website, according to Finnish media report on Monday.This act of sabotage is the largest ever of its kind in Finland. The data leak is being looked into by the Finnish National Bureau of Investigation.Anonymous Finland claimed on Monday responsibility for the publication of personal details of thousands of Finns. The group temporarily published a sample of information on 16,000 people as proof of the hack. The hack was motivated by an apparent desire to shame the Finnish government into improving data security.Finnish National Bureau of Investigation has not confirmed the claims that a loose group of hackers known as Anonymous was behind the data leak.The list that was put on the Internet contains the names, full social security numbers, addresses, telephone numbers, street addresses, and email addresses of the victims. Several upper secondary vocational education institutions are on the list, and some civil servants and students of the Police College of Finland are mentioned by name.Finnish police have confirmed that the names of some Finnish Defense Forces staff are on the list. Finnish Defense Forces found out that fewer than 10 of its employees are included, and has informed these people. The military said the leak did not pose a security threat.