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SAN DIEGO (KGTV) -- We’ve known for a while that COVID-19 hits people over 65 especially hard, but a study published Wednesday from researchers in San Diego offers new insight into why that happens.The numbers are staggering: if you’re 65 or older, your risk of winding up in the hospital from COVID-19 is five to 11 times higher than someone under 30. Your risk of death is at least 90 times higher, according to data from the Centers for Disease Control and Prevention.Researchers at the La Jolla Institute for Immunology say the reason why older people fare so much worse appears to be from a lack of T-cells, a type of white blood cell that can decline with age.“Some viruses get controlled by one part of the immune system. Some viruses get controlled by another. In this case it seems that T-cells really do a lot of the work,” said Dr. Shane Crotty, one of the authors of the study published Wednesday in the journal Cell.Dr. Crotty and his colleagues looked at 50 people infected with the virus, and they measured the three elements of the adaptive immune system in detail: antibodies, helper T-cells and killer T-cells.Then they compared the measurements to how people fared against the virus. Some patients in the study group had severe cases, others had mild infections.The researchers found that people with all three branches of the adaptive immune system tended to fully recover. People with severe cases of the virus often lacked one or more of the immune branches, and it was particularly evident in older people.“Our data indicated that of the older individuals, it was particularly the ones that had fewer T-cells to start that look like they really struggled to control this virus,” Dr. Crotty said.As we age, we have fewer T-cells to send after invading pathogens. “That collection of T-cells gets smaller. So it’s harder to recognize a new virus,” Crotty said.Among the 748 deaths in San Diego County reported as of Wednesday, 87% were people aged 60 and older.The findings from LJI may have implications in the search for a vaccine against COVID-19. The data suggests that vaccine-makers may want to target a drug that elicits all three branches of the immune response, Dr. Crotty said. Some vaccine approaches, such as inactivated virus vaccines, only elicit two of three branches, not killer T-cells. However, Crotty said it was too soon to rule any candidates. Two strong branches produced by a vaccine could potentially cover for the lack of a third, he said.Crotty said the findings could help vaccine-makers interpret results from the clinical trials and find the right dosing.“Is a given vaccine a good vaccine, and you just need a booster immunization?” he said. “Does it work well in one population but it doesn’t help in the elderly because it doesn’t generate a T-cell response, for example? Those are the scenarios when this type of knowledge will come into play.” 2906

SAN DIEGO (KGTV) — Two inmate deaths in San Diego detention facilities this year are being attributed to drug overdoses and called accidental.The first occurred on July 20 at the San Diego Central Jail, where Michael Hossfeld, 41, was found unresponsive in his cell, according to the San Diego Sheriff's Department. Deputies began life-saving measures and Hossfeld was taken to a nearby hospital, where he remained in a coma and on life support until Aug. 3.The county medical examiner this week determined Hossfeld had died from anoxic encephalopathy due to acute fentanyl toxicity and ruled his death an accident.Hossfeld had been in custody for 691 days and was charged with multiple crimes, including robbery.On Aug. 26, deputies at George Bailey Detention Facility found Jose Sevilla, 39, unresponsive in his cell. Deputies began CPR, but he was pronounced dead shortly after he was found.The medical examiner report said that Sevilla died from acute heroin intoxication and his death was also deemed an accident.Sevilla had been in jail since May 30 on drug- and theft-related charges.SDSO did not provide any further information regarding the deaths.According to the Associated Press, there have been at least 13 in-custody deaths in San Diego jails this year. 1275

SAN DIEGO (KGTV) -- Two more people have died from the flu in San Diego County, bringing this season’s total to 11, according to County News Center. According to health officials, a 74-year-old man who was vaccinated died from complications from influenza B on December 31. A 64-year-old man also died from complications due to influenza A on January 3. The 64-year-old man hadn’t received his vaccination, according to the county. Overall, flu activity was down last week compared to previous weeks. Last year at this time, 91 people had died from the flu. Flu cases last week fell to 257 from 369 the previous week. Overall, just over 2,000 cases of the flu have been reported so far this season, which fell dramatically from more than 10,300 by this time last year. “It’s not too late in the season to get your flu shot,” said Wilma Wooten, M.D., M.P.H., County public health officer. “Flu activity can last until April or May and the flu vaccine is the best way to protect yourself and others around you from influenza.”The CDC recommends that everyone 6-months-old and older get a flu shot every year. Below are some tips to help prevent the flu of you've already been vaccinated: Wash hands thoroughly and oftenUse hand sanitizersStay away from sick peopleAvoid touching your eyes, nose, and mouthClean commonly touched surfacesIf you are sick, stay home and avoid contact with others 1399

SAN DIEGO (KGTV) - Victims in a vehicle vandalism spree in Lakeside are hopeful for a break in the case, after the teen vandals apparently recorded and shared their exploits.From a broken side mirror and a cracked sunroof to the green-colored graffiti, Stephanie Starkey's Tuesday night discovery was painful."I cried. It hurt. I love my car," said Starkey.Starkey says she had taken 2011 Hyundai Sonata into a mechanic, who parked it on Woodside Avenue. Along that street, at least three other vehicles were spray-painted and one car was keyed. Some of that vandalism played out on cellphone video. Deputies say they're looking over an 8-second video, which has been shared on Instagram, showing a teen smashing Starkey's car several times with a skateboard. In the video, several voices can be heard laughing. "Can't even describe the feeling of emptiness. A hurt, broken feeling. I'm getting ready for a new job. Now I have no way to get to work ... It's obviously something they get an adrenaline rush out of ... Disgusted. Kids with nothing better to do," said Starkey.Deputies say they have not yet made an arrest. Anyone with information is asked to call Crimestoppers at 1-888-580-8477. 1202

SAN DIEGO (KGTV) - Backers of the two competing plans to replace the stadium site in Mission Valley are making their final pitches to voters in a campaign in which each side has spent millions of dollars."We've learned a lot about the politics of San Diego," said Nick Stone, Project Manager for Soccer City, which is Measure E on the ballot.Stone and his team of developers want the centerpiece of the land to be a new stadium for a Major League Soccer team. Measure E also includes promises for new housing, retail, an entertainment complex, and San Diego River park."That's what people care about," Stone told 10News in an interview the day before the election. "They want to know they're getting fair value, that something's going to happen, and that we're going to live up to the commitments we're making. And we are."Should Measure G win, the city would sell the land to the CSU system with plans for a new west campus for San Diego State University. The centerpiece to this plan is also a stadium, in this case, for the Aztecs football team. SDSU West also includes housing, retail, and a river park, along with new research and classroom space and a science center."San Diegans want their kids and their grandkids to be able to have a great education at San Diego State University. And they know that SDSU needs to expand in order for that to happen," said Yes on G spokesperson Laura Fink.Fink points to Measure G's unique coalition of supporters. "It is very rare that you see the League of Women Voters, the Sierra Club, and the conservative Lincoln Club on the same side as the Democratic Party and elected officials on both sides of the aisle."Either measure needs to top 50% of the vote to pass. If both clear 50%, the measure with the most votes will win. If neither measure gets more than 50%, neither will be enacted. 1847