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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CARLSBAD, Calif. (KGTV) — U.S. history from the Mayflower through the American Revolution is on display in Carlsbad.The Green Dragon Tavern and Museum, off Interstate 5 at Palomar Airport Road, offers a full-service restaurant and a chance to look at original documents from the country's Colonial Period."Not a lot of families have the money or time or resources to be able to travel back east and experience these things first hand," says Green Dragon General Manager John Lek. "A lot of our guests say they feel like they're in Boston or New England without having to leave San Diego."The museum's artifacts are all part of a private collection owned by a local man, who asked not to be identified. He wanted to share his collection with the rest of San Diego, and put them on display at the restaurant.Among the items are documents signed by 14 of America's founding fathers. That gives visitors a chance to see the signatures of Benjamin Franklin, Thomas Jefferson, Samuel Adams, John Hancock and more.Lek says just seeing these items can give people a deeper link to their past."There is something authentic and something that really settles in when you have a direct connection with our forefathers," says Lek.The museum has been open for five years. Right now, everything fits within a single room. But there are plans for expansion.Lek says the museum will open a second room with more interactive and hands-on technology, as well as more artifacts from America's past.Admission to the museum is free, and it's open anytime the restaurant is open. The building also includes a private event space that is available for parties.For more information about the Green Dragon Tavern in Carlsbad, click here. 1719

California regulators want to tax text messages to increase funds for programs that bring connectivity to underserved residents.A new surcharge proposed by the California Public Utilities Commission (CPUC) wouldn't be a per-text tax, but a monthly fee based a cellular bill that includes any fees for text-message services. Most carriers offer a flat fee option for texting, and already charge a similar fee for other services included in the bill — such as phone calls. The exact structure of the charge would vary from carrier to carrier.The commission will vote on the measure January 10, 2019, and is facing strong opposition from industry trade groups like the CTIA, which represents AT&T Mobility, Sprint, and T-Mobile. (AT&T is the parent company of CNN.)The 52-page proposal by CPUC Commissioner Carla J. Peterman lays out the details of the plan, and says the state's Public Purpose Program budget is going up while incoming fees to fill it are decreasing. Currently the surcharge rate is less than 7%.The proposed plan could be complicated by a new Federal Communication Commission ruling. On Wednesday, the FCC approved a new rule that classifies text messages as an "information service" like email. Proponent of the rule say it will give carriers the ability to crack down on spam messages, and critics say it could lead to carriers censoring messages.The CTIA argued in a legal filing submitted Wednesday that if texts are an information service, then the CPUC doesn't have authority over them and can't add on surcharges. It claims the proposal would go against federal law.The industry group also says the proposal would create inequity "between wireless carriers and other providers of messaging services," such as WhatsApp, iMessage and Skype."Subjecting wireless carriers' text messaging traffic to surcharges that cannot be applied to the lion's share of messaging traffic and messaging providers is illogical, anticompetitive, and harmful to consumers," the CTIA said in its filing.In light of the FCC ruling and other legal filings submitted to the CPUC, the group could change its draft proposal before the vote next month.According to the CPUC, the charges go to a number of different programs, including 911 services, subsidized phone service for low-income residents, and equipment for deaf and hard-of-hearing users. 2379

CHARLOTTE, N.C. — Authorities have filed criminal charges against a mother accused of driving around barricades during a hurricane, resulting in the drowning death of her 1-year-old son.Union County Sheriff’s detectives say that Dazia Ideah Lee, 20, of Charlotte, drove around highway barricades and kept going east until her vehicle encountered rushing water flowing across the road during Hurricane Florence.Her car left the roadway and came to a rest among a group of trees where she managed to free herself and her 1-year-old son Kaiden Lee-Welch. However, she lost her grip on Kaiden in the rushing water.“The tragic death of this child and the circumstances surrounding this case are heartbreaking. We continue to pray for all those suffering as a result of this child’s death," Sheriff Eddie Cathey stated. "However, after a very thorough investigation and taking all facts into consideration and applying the law, we feel that these charges are appropriate.”Lee faces a charge of involuntary manslaughter and a misdemeanor charge of driving on a closed/unopened highway in connection with the death of her son.She is due in court on November 20, 2018. 1192

Carlsbad (KGTV): Voters in Carlsbad could put women in charge of the local government, as female candidates overwhelmingly outnumber male candidates in the races for Mayor and City Council.Right now, there is just one woman on the five-seat council, which includes the Mayor. The lone female, Cori Schumacher, is currently running for mayor against incumbent Matt Hall.Meanwhile, Council-members Mark Packard and Michael Schumacher are not seeking reelection.Six candidates have come forward to fill their spots, five of which are women. In District One, Linda Breen, Tracy Carmichael, Barbara Hamilton, and David McGee are running. In District Three, Priya Bhat-Patel is facing Corrine Busta.Depending on the outcomes of those elections, women could hold 3 of the five City Council seats. And, even if Schumacher loses, she'll still keep her current position on the Council."I think it's about time," says Loann Simon from the League of Women Voters in North County.Simon believes the rise of the women's movement in the last few years has spurred more women to come forward and get more involved in local politics."Women are becoming braver," she says. "I think it’s something that’s evolving, but after 2016, it’s kind of flipped a switch." A "pink wave" would be rare in Carlsbad. According to the Coast News, only 11 women have been elected to the City Council in the last 66 years.Simon says more female candidates means more of a focus on women's issues, like family, health and open space."It brings their voice to the table. It’s not enough to just shout about what you want. You have to bring what you want to the table for your voice to be heard."Simon's group runs a non-partisan website that breaks down every race and issue in the upcoming election, votersedge.org. Users can enter their zip code and get a personalized breakdown of their ballot. 1893