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Immunotherapy has gained ground against a stubborn opponent: ovarian cancer. A personalized cancer vaccine is safe and may lengthen the lives of ovarian cancer patients, a small clinical trial found.The research, published Wednesday in the journal Science Translational Medicine, showed "significantly higher" overall survival at two years among patients who received the vaccine, compared with patients who did not.Ovarian cancer is a "silent killer" because often it goes unnoticed until it is diagnosed at a late stage. Treated with surgery followed by chemotherapy, most patients -- 85% -- relapse and ultimately develop resistance to the chemo. At this point, they run out of treatment options.Still, scientists are hopeful based on the fact that a subset of patients shows an immune response to their cancer. Generally, these patients have better survival rates than those whose immune systems don't react in the same way.A vaccine, then, might be able to trigger and boost the immune system and increase the survival rates of patients, said Dr. Lana Kandalaft, senior author of the new study and an adjunct assistant professor at the University of Pennsylvania Perelman School of Medicine.  1210

Hurricane Michael is bearing down on the Florida Panhandle with frightening fury.The Category 4 storm is packing winds of 130 mph and may grow even fiercer before it makes landfall Wednesday, likely near Panama City Beach.Photos: Hurricane Michael to slam US coastIn terms of wind intensity, that would make it stronger than Hurricane Florence, which had winds of 90 mph when it blew ashore in North Carolina last month.Here are some other facts that show the power of this "monstrous storm." 500

House Democrats elected to keep their leaders in place on Wednesday, marking a win for the party's moderate wing.The party confirmed Wednesday that Rep. Nancy Pelosi, D-California, would continue to serve as Speaker of the House. Rep. Steny Hoyer, D-Maryland, will again serve as the House Majority Leader, Rep. James Clyburn, D-South Carolina, will continue to serve as the House Majority Whip, and Rep. Hakeem Jeffries will keep his role as the chairman of the House Democratic caucus.No other Democrats mounted serious challenges to current party leadership positions.Pelosi's upcoming term will mark her fourth as Speaker of the House. She previously served as speaking when Democrats held the majority in the House from 2007 to 2011, and she was elected as Speaker again when Dems won back control following the 2016 midterms.Though House Democrats will be working with a Democrat president in Joe Biden next term, serious questions remain about the future of the party.Democrats went into the 2020 election hoping to control both chambers of Congress and the White House — and plenty of polling suggested that they would do so. But Democrats lost seats in the House in the 2020 election, and the control of the Senate hinges on two January run-off elections in Georgia — meaning Biden could face significant challenges in getting his legislation passed. 1367

IMPERIAL BEACH, Calif., (KGTV) — After six grueling days on the fire line, members of the San Diego-based Strike Team called to fight the Kincade Fire are back home. 10News met with the fire crew from Imperial Beach, who said this was the first time in 11 years that they were called to assist in Northern California. Today, they were back on duty, just hours after their arrival. It's just another day at the Imperial Beach firehouse. Fire Engineer Cory Cooper, firefighter Nick Morales, and Captain Ehren Kahle are cleaning up their ride, Engine 39, after a long trip up north. "It was just kind of a gentle immersion into chaos," Kahle said. Last Friday, the three were part of a large San Diego-based Strike Team called to assist in Sonoma County. As soon as they arrived, they headed straight to the fire line. "It started out with light smoke, which progressively got worse, to a point where my engineer had difficulty seeing the road at some point," Kahle said. Buildings had crumbled, citizens were in chaos. But they were there, fighting the explosive flames, seemingly non-stop."We rest when we can," Kahle laughed. Once the spread slowed down, the team headed back home. The men arrived at 11 p.m. on Thursday. While firefighters in larger departments are given a 24-hour rest period, these guys with the small Imperial Beach department are already back on shift."We're right back to our normal routine."It's day-to-day calls like these, as well as being part of a large Strike Team that reminds Captain Kahle of the true camaraderie of the fire service. "Although I may be going out on a Strike Team with men that I have never worked with or never even met in my entire life, you can probably take a firefighter off of an engine from San Diego, Coronado, National City, or Poway, throw them onto their engine, and they will drive right into that crew and be able to function," Kahle said. To follow current information on the Kincade Fire, click HERE. 1971

If you’re holding onto a Toys “R” Us gift card or store credit, you’ll want to use it very soon.The company recently announced its closing all of its stores, and told Scripps station WRTV in Indianapolis that customers have only until April 15, 2018 to use gift cards.However, it’s a good idea to use them as soon as possible, whether in-store or online, according to the Federal Trade Commission.If you do buy something, consider it a “final sale” and don’t plan on getting a refund if you buy something that doesn’t work.“Even if store credit is an option – you’d want to use that quickly too. If you have questions about refund and return policies, ask before you make any purchase,” said Colleen Tressler, FTC Consumer Education Specialist. “In addition, Toys"R"Us says its other customer programs, including Rewards dollars and Endless Earnings, are being honored for the next 30 days.The?news of the 735 store closures means shoppers can expect discounts as the retailer liquidates.Depending on the timeline, the sales could be modest at first. The biggest discounts will come later.Over nearly seven decades in business, Toys "R" Us has built up 1,600 stores around the world. About 880 of them are in the U.S. 1235