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Immunotherapy has gained ground against a stubborn opponent: ovarian cancer. A personalized cancer vaccine is safe and may lengthen the lives of ovarian cancer patients, a small clinical trial found.The research, published Wednesday in the journal Science Translational Medicine, showed "significantly higher" overall survival at two years among patients who received the vaccine, compared with patients who did not.Ovarian cancer is a "silent killer" because often it goes unnoticed until it is diagnosed at a late stage. Treated with surgery followed by chemotherapy, most patients -- 85% -- relapse and ultimately develop resistance to the chemo. At this point, they run out of treatment options.Still, scientists are hopeful based on the fact that a subset of patients shows an immune response to their cancer. Generally, these patients have better survival rates than those whose immune systems don't react in the same way.A vaccine, then, might be able to trigger and boost the immune system and increase the survival rates of patients, said Dr. Lana Kandalaft, senior author of the new study and an adjunct assistant professor at the University of Pennsylvania Perelman School of Medicine.  1210

In a sharp turn of events, a San Francisco judge denied Monsanto's request to nix a 0 million award to a man who said he got terminal cancer from Roundup weedkiller.But she's also slashing that man's punitive award down to about million.Former school groundskeeper Dewayne Johnson was the first cancer patient to take Monsanto to trial, claiming Roundup gave him non-Hodgkin's lymphoma.Jurors sided with Johnson and awarded him 0 million in punitive damages (to punish Monsanto) and about million in compensatory damages (for Johnson's lost income, pain and suffering).The jury's verdict came in August. But on October 10, the tide appeared to turn in Monsanto's favor.That's when Superior Court Judge Suzanne Bolanos issued a tentative ruling granting Monsanto's request for a JNOV -- a judgment notwithstanding verdict. That's basically when a judge in a civil case overrules the jury's decision.Bolanos said the plaintiff "presented no clear and convincing evidence of malice or oppression to support an award of punitive damages." In other words, Johnson's entire 0 million punitive award was in jeopardy.The judge gave attorneys on both sides a few days to respond and further make their cases.When she issued her final ruling Monday, Bolanos reversed her tentative ruling and denied Monsanto's request for a JNOV.But it wasn't a complete victory for Johnson. Instead of 9 million in combined damage awards, Johnson is slated to get a total of about million.Bolanos said the punitive award was too high and needed to match Johnson's million compensatory award."In enforcing due process limits, the court does not sit as a replacement for the jury but only as a check on arbitrary awards," Bolanos wrote in her ruling Monday."The punitive damages award must be constitutionally reduced to the maximum allowed by due process in this case -- ,253,209.35 -- equal to the amount of compensatory damages awarded by the jury based on its findings of harm to the plaintiff."Monsanto had also requested a new trial on the punitive damages. The judge said that request will be denied if Johnson accepts the smaller punitive award. If he does not accept the million punitive award, then a new trial would be set.The 1 million plummet in Johnson's punitive award caught some legal experts by surprise, including University of Richmond?law professor Carl Tobias."I am somewhat surprised, but the punitive damage award was high even though the (percentage of) reduction was steep," Tobias said. "No one thought the plaintiff would retain the whole (punitive damages) award." 2626

Howard County Police release surveillance video of a woman burglarizing the McDonald's in Columbia, Maryland.This happened at 1 a.m. on Sunday, November 5.Police said the woman entered the restaurant through the drive-thru window.She stole cash and food before leaving.Detectives are offering a reward of up to 0 for information in this case.  369

HOUSTON (AP) — Houston officials have canceled the Texas GOP’s in-person convention.They say the spread of the coronavirus made it impossible to hold the event as scheduled.Houston Mayor Sylvester Turner said Wednesday that the city’s lawyers exercised provisions in the contract that the Texas Republican Party signed to rent the downtown convention center for a three-day event to have started July 16.Virus cases have surged in Texas, particularly in the state’s largest cities.Republican Gov. Greg Abbott had publicly deferred to state party leaders who last week voted to go forward with an in-person event. 620

Housing and Urban Development Secretary Ben Carson detailed his wife's involvement Tuesday in picking out a dining room set for his office, telling a House subcommittee, "I left it with my wife."Carson said that his wife, Candy, selected "a style and a color" of the furniture set that ultimately cost HUD ,000."A style and a color was selected by her with the caveat that we were not happy with the pricing and they needed to find something," Carson told lawmakers.He went on to defend her, "If anybody knew my wife, they would realize how ridiculous this was. She's the most frugal person in the world."A HUD spokesperson had previously told CNN in a statement last month that "Mrs. Carson and the secretary had no awareness that the table was being purchased." Internal HUD emails indicated that the Carsons had picked out the furniture.Carson said Tuesday the issue of replacing the dining room set was raised "because people were being stuck by nails, the chairs collapsed with somebody sitting in it, it's 50 years old.""I said, 'OK, we can potentially do that.' I asked my wife also to help me with that," he told lawmakers."They showed us some catalogs. The prices were beyond what I wanted to pay. I made it clear that just didn't seem right to me. And, you know, I left it with my wife," he said.Carson argued that he wasn't concerned about the furniture because he had more important issues to handle as HUD secretary.Carson said he first heard of the ,000 price tag after it was reported and "immediately" canceled the order from the interior design firm Sebree and Associates in Baltimore, Maryland. He testified that the money spent on the dining set was returned to the US Treasury."I'm not really big into decorating. If it was up to me, my office would probably look like hospital waiting room," quipped Carson, who previously worked as a neurosurgeon.He said his wife is not involved in any other decisions regarding the purchasing of furniture for HUD.Carson was also asked about inconsistencies in the messaging from the agency regarding how involved he and his wife were in the process to purchase the dining set compared to what internal HUD emails indicate. The emails were released through a Freedom of Information Act request."There appears to be some contradiction in the record about your statements to the press indicating early on that you had no knowledge of this purchase," Rep. David Price, D-North Carolina, said to Carson.Carson denied he ever spoke directly to the press.When Price pointed to the statement that the HUD spokesman provided to CNN at the time, Carson distanced himself from his spokesman's comments."I would respectfully tell you what I said. I can tell you what I did. I do not intend to be responsible for what anybody else said," Carson said.Carson then said that the content of his statement made via Facebook?where he personally addressed the issue "is quite accurate." 2953

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