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WASHINGTON, Nov. 18 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Friday revoked its approval of Avastin for treating the breast cancer after concluding that the drug has not been shown to be safe and effective for that use.Avastin will still remain on the market as an approved treatment for certain types of colon, lung, kidney and brain cancer."After reviewing the available studies it is clear that women who take Avastin for metastatic breast cancer risk potentially life-threatening side effects without proof that the use of Avastin will provide a benefit, in terms of delay in tumor growth, that would justify those risks," FDA Commissioner Margaret Hamburg said in a statement. "Nor is there evidence that use of Avastin will either help them live longer or improve their quality of life. "Avastin's risks include severe high blood pressure; bleeding and hemorrhaging; heart attack or heart failure; and the development of perforations in different parts of the body such as the nose, stomach, and intestines.Avastin was approved for metastatic breast cancer in February 2008 under the FDA's accelerated approval program, which allows a drug to be approved based on data that are not sufficiently complete to permit full approval. After the approval, the drug's sponsor, Genentech, completed two additional clinical trials and submitted the data from those studies to the FDA. These data showed only a small effect on tumor growth without evidence that patients lived any longer or had a better quality of life compared to taking standard chemotherapy alone -- not enough to outweigh the risk of taking the drug.FDA's Center for Drug Evaluation and Research, which is responsible for the approval of this drug, ultimately concluded that the results of these additional studies did not justify continued approval and notified Genentech it was proposing to withdraw approval of the indication.Genentech did not agree with the Center's evaluation of the data and, following the procedures set out in FDA regulations, requested a hearing on the Center's withdrawal proposal, with a decision to be made by the Commissioner. That two-day hearing, which took place June 28-29, included recommendations from the FDA 's Oncologic Drugs Advisory Committee, voting 6-0 in favor of withdrawing approval of Avastin's breast cancer indication.

CANNES, France, Nov. 3 (Xinhua) -- Chinese President Hu Jintao on Thursday urged the world's major economies to work together to promote growth and financial stability."It is imperative that we stand on a higher plane, transcend differences on specific issues, move beyond short-term considerations, and jointly seek ways to overcome the crisis and sustain development," Hu told the Group of 20 (G20) summit here."At this critical moment, the G20 must work to address the key problems, boost market confidence, defuse risks and meet challenges and promote global economic growth and financial stability," said Hu.As the premier forum for international economic cooperation, the G20 must continue to demonstrate the spirit of standing together in times of adversity and pursuing win-win cooperation, he said.The Chinese president said "the current world economic situation deserves our high attention," cautioning the global recovery is fraught with instability and uncertainty and faces growing risks and challenges.Some major economies are experiencing economic slowdown and some countries are facing acute sovereign debt problems, said Hu.He also cited volatility in the international financial markets, and high inflationary pressure in emerging markets.Hu put forward a five-point proposal on what G20 nations need to do to tide over the crisis.First, the countries should ensure growth while paying attention to balance. Given the serious risks facing the global economy and continued market volatility, ensuring growth and promoting stability should be the top priority, he said."We should introduce new and strong measures to ensure that fiscal and monetary policies are fully implemented and that funding is channeled into the real economy to boost production and employment."Second, the G20 nations should strengthen unity and send a strong signal to the world as there is widespread panic and acute lack of confidence in the markets, said Hu.He urged G20 members to strengthen consultation and coordination, tackle sovereign debt risks, regulate cross-border capital flow, put the fluctuation of commodity prices under control, mitigate global inflationary pressure and make sure that the economic policies pursued by various countries do not offset each other.Third, global economic governance should be improved through reform, Hu said.The international financial crisis has highlighted the deficiencies in the global economic governance system, said Hu."Major efforts should be made to reform and improve the international monetary system, international trading system and commodity pricing mechanism," said the Chinese president.

SAN FRANCISCO, Oct. 17 (Xinhua) -- Apple on Monday announced that it has sold more than four million of its new iPhone 4S, three days after the launch last Friday."IPhone 4S is off to a great start with more than four million sold in its first weekend--the most ever for a phone and more than double the iPhone 4 launch during its first three days," said Philip Schiller, Apple's senior vice president of worldwide product marketing.In addition, more than 25 million customers are already using iOS 5, the latest version of the mobile operating system powering Apple's mobile devices, since it was released last Wednesday; and more than 20 million customers have signed up for iCloud, the cloud service designed to store and sync data for download to multiple devices, said the company in the statement.The iPhone 4S, which looks the same as the iPhone 4, has major hardware upgrade inside, including a faster chip, a higher- resolution camera and Siri intelligent voice control.Last Friday, AT&T and Sprint, two iPhone wireless carriers in the United States, said they have seen record daily sales with the launch of the iPhone 4S.The lasted Apple smartphone is currently on sale in the U.S., Canada, France, Germany, Japan and Britain, and will be available in 22 more countries on Oct. 28. Apple said the phone will be on sale in more than 70 countries and regions by the end of this year.

SANTO DOMINGO, Sept. 30 (Xinhua) -- Haitian health authorities on Friday said the number of deaths caused by cholera increased to 6,435 in the Caribbean country since October 2010.The Haitian Health Ministry said the number of people infected with cholera almost reached half a million, although the ministry repeated the epidemic was decreasing.The report said 455,727 people had been treated due to cholera, and 242,205 had to be hospitalized.The western province of Artibonite suffered the plague most with 1,196 deaths. The southwest province of Nippes registered the smallest death toll of 181.Meanwhile, in the Haitian capital Port-au-Prince, 221 people have been killed since October 2010 when the epidemic first broke out in central Haiti.The epidemic is supposedly due to the spill of dregs from a Nepalese camp, which is part of the UN Stabilization Mission in Haiti (MINUSTAH).The Dominican Republic, a country neighboring the island country Haiti to the east, has also been suffering the disease since November 2010, which has killed at least 135 people there.