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The transformation of 7% of Scott's DNA suggests longer-term changes in genes related to at least five biological pathways and functions.The newest preliminary results from this unique study of Scott, now retired from NASA, were released at the 2018 Investigator's Workshop for NASA's Human Research Program in January. Last year, NASA published its first round of preliminary results at the 2017 Investigator's Workshop. Overall, the 2018 findings corroborated those from 2017, with some additions.To track physical changes caused by time in space, scientists measured Scott's metabolites (necessary for maintaining life), cytokines (secreted by immune system cells) and proteins (workhorses within each cell) before, during and after his mission. The researchers learned that spaceflight is associated with oxygen-deprivation stress, increased inflammation and dramatic nutrient shifts that affect gene expression.In particular, Chris Mason of Weill Cornell Medicine reported on the activation of Scott's "space genes" while confirming the results of his separate NASA study, published last year.To better understand the genetic dynamics of each twin, Mason and his team focused on chemical changes in RNA and DNA. Whole-genome sequencing revealed that each twin has more than expected unique mutations in his genome -- in fact, hundreds.Although 93% of Scott's genetic expression returned to normal once he returned to Earth, a subset of several hundred "space genes" remained disrupted. Some of these mutations, found only after spaceflight, are thought to be caused by the stresses of space travel.As genes turn on and off, change in the function of cells may occur. 1676
The suspects first tried to smash their way into a Saint Laurent shop, but failing that ended up breaking into and burglarizing the Zadig et Voltaire boutique next door. 169
The wildfire is one of nearly two dozen burning across the state. https://t.co/5u3t4XuFYr pic.twitter.com/a7h5kfxuvS— ABC News (@ABC) August 8, 2018 148
The spaceship has a mostly white interior with a cockpit big enough for two pilots. Up to six passengers will be able to sit abroad the SpaceShipTwo, with plenty of windows to capture all the beautiful scenes you'll be witnessing up in space. 242
The sea lion responsible for biting Pagnini was transferred to a Marine Mammal Center in Sausalito. It will be treated with food free of domoic acid over a week, after which it will undergo neurological examinations. If the sea lion has permanent brain damage, it may need to be euthanized, Tognazzini said. 307
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