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U.S. government officials are putting an early end to a study testing an Eli Lilly antibody drug for people hospitalized with COVID-19 because it doesn’t seem to be helping them.Independent monitors had paused enrollment in the study two weeks ago because of a possible safety issue. But on Monday, the National Institute of Allergy and Infectious Diseases, which sponsors the study, said a closer look did not verify a safety problem but found a low chance that the drug would prove helpful for hospitalized patients.It is a setback for one of the most promising treatment approaches for COVID-19. President Donald Trump received a similar experimental, two-antibody drug from Regeneron Pharmaceuticals Inc. on an emergency basis when he was sickened with the coronavirus earlier this month.In a statement Lilly notes that the government is continuing a separate study testing the antibody drug in mild to moderately ill patients, to try to prevent hospitalization and severe illness. The company also is continuing its own studies testing the drug, which is being developed with the Canadian company AbCellera.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. The experimental drugs are concentrated versions of one or two specific antibodies that worked best against the coronavirus in lab and animal tests.Lilly and Regeneron have asked the U.S. Food and Drug Administration to grant emergency use authorization for their drugs for COVID-19 while late-stage studies continue. Lilly says its request is based on other results suggesting the drug helps patients who are not hospitalized, and that it will continue to seek the FDA’s permission for emergency use.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 1928
US President Donald Trump on Thursday abruptly canceled his meeting with Russian President Vladimir Putin, which was scheduled to occur during a G20 meeting in Buenos Aires."Based on the fact that the ships and sailors have not been returned to Ukraine from Russia, I have decided it would be best for all parties concerned to cancel my previously scheduled meeting [...] in Argentina with President Vladimir Putin. I look forward to a meaningful Summit again as soon as this situation is resolved!" Trump tweeted en route to the summit.Earlier Thursday, Trump told reporters that he would still "probably" meet with Putin, despite a recent incident in which Russian ships opened fire on and seized three Ukrainian vessels near Crimea."I probably will be meeting with President Putin. We haven't terminated that meeting. I was thinking about it, but we haven't. They'd like to have it. I think it's a very good time to have a meeting. I'm getting a full report on the plane as to what happened with respect to that," he said ahead of his departure on Marine One.Trump added that he will be getting a "full report on the plane" on recent Russian aggression in Ukraine "and that will determine" his course of action. 1222
VALLEY CENTER, Calif. (KGTV) - Amid a COVID-related cancellation at a Valley Center cemetery, a community is coming together to help save an annual tradition.Valley Center Cemetery is the final resting place to more than 300 veterans. On Friday, local florist Jenelle Brinneman learned an annual holiday sight would not be laid out.She says the local chapter of a nonprofit that puts down Christmas wreaths at military grave markers announced there would be no wreaths, citing logistical problems in placing them amid COVID-19 restrictions and stay-at-home orders."Our hearts dropped, because we know how much it means," said Brinneman.On Memorial Day and Veterans Day, Brinneman raised money to place roses at military grave sites amid similar cancellations."There were strangers thanking us. People were crying, watching us put roses down," said Brinneman.Undeterred after the most recent disappointment, Brinneman posted on Facebook on Friday a call for donations to make wreath sprays, a smaller version of wreaths. When she returned home Saturday evening, she discovered something astounding."I just started crying right there. Our town is amazing ... My driveway was filled with pine, cedar, ribbons, and wreaths companies were about to throw away," said Brinneman.Brinneman set up a workshop in her driveway. Dozens of volunteers have signed up to help assemble."This is what the Christmas spirit is all about," said Brinneman.She's also hoping to include message from kids."It will be so great to walk past and see a little note attached from an amazing child in our town," said Brinneman.Brinneman says come Christmas Eve -- thanks to a community's support -- she'll be able to place the sprays at every military grave marker in the cemetery."They deserve to be recognized. Seeing the wreaths on the grave markers is something unexplainable. Because of the community, loves ones will see those wreaths," said Brinneman.Brinneman is still in need of a lot of messages from kids. If you'd like to send a message, take a photo of the child's handwritten message and email it to bellanifloralevents@outlook.com. You can also drop off a handwritten message at Fat Ivors Rib Rack between 11 a.m. and 8 p.m. or the mailbox at Bellani Floral. 2251
Veterinarians have a warning for pet owners about an ingredient in some foods — including peanut butter — that can be toxic to your pet.It's a sweetener, called xylitol, that's found in different brands of peanut butter, and it can make your pet sick, or even kill them. The ingredient can also cause liver failure."It's kind of horrible to think about because it's common knowledge — everyone gives their dog peanut butter," Laura Lovely said.Lovely said it's devastating to learn her dog Sweetie's favorite snack could send her to the emergency room."Whenever she wants kind of a healthy treat, because it has a lot of protein, and when she takes her medication," Lovely said.It's a food Lovely said she and Sweetie both enjoy."Xylitol is a wonderful low calorie sweetener for you and me but it can be deadly for our dogs," veterinarian Dr. Christopher Byers said.It's not just in peanut butter. Byers said you'll find xylitol in a number of products."Certain brands of peanut butter, toothpaste, certain gums, certain breath mints," Byers said.He said your dog can be exposed to it by accident."One of the more common gums that we encounter in the emergency room is Orbit," Byers said. "Orbit is a great product, but it does contain xylitol."Within a half-hour, he said, your dog's blood sugar will start to plummet."They can be lethargic. They can collapse. They can even have seizures," Byers said.So it's essential for all dog owners to check labels, he said."I think it's awful," Lovely said. "if it's not healthy for dogs, how is it supposed to be healthy for us as well?" Byers said they see xylitol intoxication in dogs several times a week, and that if you see the signs, get your dog to the emergency room as soon as possible. 1791
UPDATE: CMA reverses media ban on talk about Las Vegas shootingThere are three things the CMA Awards prefer media avoid when talking to artists in Nashville next week: the tragedy in Las Vegas, gun rights, and politics. CMA Awards:?Tim McGraw, Faith Hill, P!NK and Keith Urban added to CMA Awards performance lineupIn a set of media guidelines distributed to credentialed journalist covering the award show, the CMAs specifically asks reporters to stay away from the "Las Vegas tragedy, gun rights, political affiliations or topics of the like". 558