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JUPITER, Fla. — Groundbreaking research out of the Scripps Research Institute in Jupiter, Florida found a genetic explanation for the pain processing and sensory issues some children living with autism face."To see the biology in the lab turn out that has parallels to what’s going on in these children takes it so far beyond just an academic endeavor," said Dr. Gavin Rumbaugh, a neuroscientist at Scripps. "You go home every day thinking, unbelievably, I may actually be making a difference in someone's life."One of those children who Rumbaugh hopes to help with his research is 10-year-old Beckett, who lives in Texas."We wanted to understand generally in the lab how genes like SYNGAP1 affect the way the brain functions and we thought what better way was then to look and see how this gene may directly affect sensory processing, and then further on ask the question, 'Does the change in sensory processing actually lead directly to learning, memory and behavioral impairment?' " he said.Beckett has a genetic mutation of SYNGAP1, which researchers have now found causes certain issues he faces, particularly, having an extremely high pain threshold while also experiencing heightened sensitivity to another kind of stimuli. Beckett and other children living with this genetic mutation also often have epilepsy."It's all about quality of life. Everybody deserves to live their best life and that's my mission," said Monica Weldon, Beckett's mom.Weldon said the research being done in Jupiter could change her son's life and the lives of hundreds of other children around the world with the same genetic abnormality and symptoms, some of whom whose families she's connected with online."That is the power I believe of a patient group that is motivated to find treatments for their loved ones," Weldon said. "Also, you've got scientists who are listening. They're willing to listen and they're willing to learn."The next step in Rumbaugh's research is to look at treating the symptoms from the genetic mutation. 2043

Jared Kushner tells CNBC that President Trump’s speech tonight will be “hopeful” and will be about the president’s “right decisions” and needed “steady hand” during a pandemic. He adds the administration is “making great progess” on getting a coronavirus vaccine.— Yamiche Alcindor (@Yamiche) August 27, 2020 316

JCPenney is in serious trouble. There's no sugarcoating it.The department store chain, famous for its Christmas catalogs, is losing money — and customers. It has a lot of debt. And not much cash.A dismal earnings report on Thursday only reinforced that time is running out. JCPenney reported an adjusted loss of million in the first quarter, even worse than Wall Street was expecting, and lowered its projections for the year. Sales fell 4 percent, also missing estimates.Much like floundering rival Sears, JCPenney is struggling to adapt to the changing retail landscape as people increasingly shop on their phones. 628

JACKSONVILLE, Fla. (AP) -- Court records show that a man accused of killing two people and then himself at a video gaming competition in Florida had been hospitalized for mental illness, according to the Associated Press. Divorce filings from the parents of 24-year-old David Katz of Baltimore say that as a teenager he was twice hospitalized in psychiatric facilities and that he was prescribed anti-psychotic and anti-depressant medications.The records show Katz's parents disagreed deeply on how to care for their troubled son.Katz's father claimed his estranged wife was exaggerating symptoms of mental illness as part of the couple's long-running and acrimonious custody battle. They divorced in 2007.Authorities say Katz killed two people and wounded nine others Sunday before fatally shooting himself at the "Madden NFL 19" tournament in Jacksonville. 876

JAPATUL VALLEY (CNS) - A fire that has blackened 17,665 acres in rural eastern San Diego County remains at 87% containment Sunday, authorities said."Fire activity was minimal overnight as firefighters continue to mop up hot spots and secure the fire perimeter," according to a U.S. Forest Service news statement. "Structure defense remains a priority for values at risk. Every day the fire stays within its current perimeter, the threat to the adjacent communities continues to diminish. High pressure over Southern California will result in a warming trend into the middle of the week."The Valley fire, southeast of Alpine, has destroyed 30 residences and 31 outbuildings, damaged 11 other structures and injured three firefighters.RELATED: Resource event gets Valley Fire victims back on their feetFire activity was limited Saturday as firefighters continued to mop up hot spots and secure the fire perimeter, officials said. A high-pressure system was expected to keep temperatures high through the rest of the weekend.At noon Friday, Cal Fire announced that all evacuations and road closures necessitated by the conflagration, dubbed the Valley Fire, had been lifted.Saturday morning, the county announced the reopening of the Lake Morena and Potrero campgrounds that had been closed during the evacuation orders. Campsites were available to book at http://reservations.sdparks.org.However, the Cleveland National Forest remained closed to the public until further notice "to protect natural resources and provide for the safety of the public and firefighters," Cal Fire advised.RELATED: Valley Fire claims Jamul woman's home, beloved animals"This closure will stay in place until conditions improve and we are confident that national forest visitors can recreate safely," officials with the state agency said.The blaze erupted for unknown reasons early Sept. 5 off Spirit Trail and Carveacre Road and spread rapidly through tinder-dry vegetation amid sweltering heat and high winds, Cal Fire officials said.The agency cautioned those returning to the fire-ravaged area to "use extreme caution around trees, power poles and other tall objects or structures that may have been weakened" by the blaze.The San Diego County Sheriff's Department was increasing its patrols in the area to ensure public safety and prevent looting.Officials advised that motorists in the area could face traffic disruptions due to the continued presence of firefighters, law enforcement personnel and utility workers still in the area.Non-residents were asked to avoid locales in and around the burn zone if possible.About 140 San Diego Gas & Electric customers in Alpine, Barrett Lake, Dehesa, Lyons Valley and Rancho Palo Verde lost power during the fire fight.Due to smoke drifting over much of the San Diego region, the county Pollution Control District advised that the air quality might be unhealthy in some local communities and advised people to limit outdoor activities until conditions improve.Gov. Gavin Newsom declared a state of emergency for San Diego County on Sunday Sept. 6 due to the Valley Fire, a move intended to free up federal relief funds.County officials encouraged people who have lost their homes or other property to the wildfire to call for assistance at 858-715-2200 or email valleyfirerecovery.@sdcounty@ca.gov.Additionally, a county assistance center for victims of the blaze will be in operation at Rancho San Diego Library, 11555 Via Rancho San Diego, on Saturdays and Sundays from 10 a.m. to 6 p.m. and Mondays from 11 a.m. to 7 p.m. until further notice.Those who would like to help victims of the fire can make donations to a disaster-relief fund implemented by the San Diego Foundation, which can be accessed online at sdcountyrecovery.com. 3770

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