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SAN DIEGO (CNS) - A COVID-19 vaccine trial sponsored by drugmaker Johnson & Johnson is slated to get underway soon in San Diego, and will include an estimated 2,000 participants at UC San Diego Health, it was announced Thursday.Up to 60,000 participants will be recruited from 10 different countries around the world as the San Diego portion of the trial, dubbed ENSEMBLE, gets underway Oct. 7, according to UCSD.The efficacy, safety and immunogenicity of the drug Ad.26-COV2.S will be tested via a randomized, double-blind, placebo-controlled study, in which half of the participants receive a single-dose injection of the vaccine and the other half receive a placebo. All participants -- who must be 18 years of age or older and in reasonably good health -- will be monitored for signs of infection and COVID-19 over the next two years, according to UCSD.Researchers are particularly interested in recruiting participants at increased risk of SARS-CoV-2 infection due to where they live, their age or personal circumstances, such as working in essential jobs like first responders, health care, maintenance, construction, grocery stores or assisted living facilities.The San Diego trial will also emphasize participation from the region's underserved communities, as communities of color have shown higher rates of COVID-19-related hospitalization and/or death.UCSD cited data from the county showing measurably higher infection rates in the South Bay, including in Chula Vista, Imperial Beach and National City.Susan Little, professor of medicine at UC San Diego School of Medicine and principal investigator of the UC San Diego trial, said, "Many communities of color are experiencing higher rates of hospitalization related to COVID-19 than are observed in white, non-Hispanic people. It is important that these communities are represented in COVID-19 vaccine clinical trials so that we understand if the vaccine will work well within these groups."For more information about participating in the trial at UC San Diego, go to www.covidvaccinesd.com or call 619-742-0433. 2087

SAN DIEGO (AP) — Wil Myers homered twice, including San Diego's seventh grand slam of the season, Austin Nola hit a three-run shot and Mike Clevinger was impressive in his home debut for the Padres, who routed the Colorado Rockies 14-5.The Padres, cruising toward their first postseason appearance since 2006, won their third straight and for the seventh time in nine games.Myers hit his slam in the five-run first inning and then homered leading off the seventh to match his single-game high of five RBIs.His 11th homer gave him his eighth career multi-homer game.Clevinger picked up his first win as a Padre, striking out eight in five innings of work. 662

SAN DIEGO (CNS) - A flurry of businesses can reopen Friday throughout San Diego County, but community-transmitted COVID-19 outbreaks have activated one of the county's public health triggers, placing a pause on any additional openings allowed by the state.The county also reported 238 new cases of the illness on Thursday, a new daily high and one that moved the total number of cases in the county over the 10,000 milestone to 10,092. Another four deaths were reported Thursday, raising the total deaths related to COVID-19 to 331.These new cases comprise 2% of a new daily high of tests reported, 10,070, for a cumulative total of 254,391 tests since the pandemic began.The businesses scheduled to open Friday, including personal care businesses like skin care and waxing salons, tattoo parlors, massage therapists and nail salons -- will still be allowed to open, but San Diego County Supervisor Nathan Fletcher said any further openings allowed by Gov. Gavin Newsom wouldn't be implemented until numbers go down."We continue to implore the public to wear facial coverings and avoid having gatherings at your home," Fletcher said.The culprit in the county's pause action is the eight community- transmitted outbreaks San Diego County has recorded in the last week.As part of the 13 public health triggers announced earlier this month, the county could take industry-specific actions, pause all reopening efforts or even dial back reopenings if enough of the metrics rise above a certain threshold. The threshold for community outbreaks -- defined as three or more lab-confirmed cases from different households -- was seven or fewer in a week's span.The eight outbreaks from June 11-17 is the most in a one-week span since the pandemic began, eclipsing the previous high of six during the week of April 29-May 5.However, if no new outbreaks are reported Friday, three of those outbreaks will fall off the rolling seven-day period the county is monitoring, bringing the metric back to "green."The two outbreaks reported Thursday were at a campground and a social club. Fletcher did not report where exactly those were, or the previous outbreaks, saying doing so would "undermine" the county's cooperation from self-reporting businesses and other locations.Nolita Hall posted on its Facebook page that an asymptomatic employee had tested positive for COVID-19 and that the Little Italy restaurant would close until June 30 for deep cleaning. It was unclear as of Thursday if that restaurant was one of the community outbreaks reported, but Dr. Wilma Wooten, the county's public health officer, said the outbreaks reported at restaurants were only among staff.Fletcher said the county would increase "targeted enforcement" of businesses in violation of public health orders.Newsom announced Thursday that Californians would be required to wear masks in public. San Diego County as well, as eight other counties in the state, already had such orders in place.Exemptions include children under the age of 2, those with hearing disabilities or who work with those with hearing disabilities who need to see mouths to communicate, and those who otherwise have a medical issue that causes masks to pose a danger to their wellbeing.Masks are not needed in private transportation, at work when not interacting with the public or while exercising so long as a person can maintain social distancing.Wooten, with a nod to how long the COVID-19 pandemic could impact the region, said it may not be safe for people to have gatherings at their homes "until sometime next year," a far cry from the mid-March hopes of flattening the curve and ending the pandemic."With the reopenings, people think we can go back to the pre-COVID existence, and we cannot," she said.A total of 106 outbreaks of the illness have been tracked since the pandemic reached San Diego, with more than half currently inactive. Past community outbreaks have included church meetings, parties and a wedding.A proposal from Faulconer was announced Thursday aimed at creating more outdoor dining and retail space for San Diego businesses, which he says will help make up for revenues lost due to indoor restrictions put in place to slow the spread of COVID-19. It would have the city waive fees and fast-track permitting needed to expand businesses outdoors into parking lots, sidewalks and on-street parking spaces.New testing sites at the Spring Valley Library on Kempton Road and the Mira Mesa Senior Center on Mira Mesa Boulevard have joined nearly a dozen other sites where county residents can get tested for free.The county launched an interactive website earlier this week that allows residents to find COVID-19 testing locations near them. The website can be found at 211sandiego.org. 4755

SAN DIEGO (AP) — A federal judge has temporarily lifted a visa ban on a large number of work permits, undercutting a measure that the Trump administration says will protect American jobs in a pandemic-wracked economy. Judge Jeffrey White in Oakland, Calif., a George W. Bush appointee, says President Donald Trump likely acted outside the bounds of his authority. The preliminary injunction applies to hundreds of thousands of members of organizations that sued the administration — the U.S. Chamber of Commerce, National Association of Manufacturers, National Retail Federation, technology industry group TechNet and Intrax Inc., which sponsors cultural exchanges.White said his order didn’t extend beyond those groups but noted they are comprised of “hundreds of thousands of American businesses of all sizes from a cross-section of economic sectors,” including Microsoft Corp. and Amazon.com Inc. 907

SAN DIEGO — Two of San Diego's biggest restaurant groups are sounding the alarm over state Coronavirus regulations.Owners of the Brigantine Family of Restuarants and the Cohn Restaurant Group say indoor capacity limits aren't sustainable. Currently, a restaurant can only seat 25 percent of its capacity indoors. “If we stay open and as we enter the fall and winter months, our restaurants cannot survive on 25 percent," said Leslie Cohn, of the Cohn restaurant group.The Cohn Group spent more than 0,000 creating social distancing in 16 of its restaurants - before the 25 percent capacity limit was instituted. Their employment is now down 40 percent to about 1,200 workers.“We should be concentrating on positive test percentages, hospital capacity, ICU and PPE availability and of course mask wearing, social distancing and employee screening,” Cohn said.Her frustrations, echoed by Mike Morton, who heads the Brigantine Family of Restaurants, where employment is off 20 percent to 1,000 workers. Morton said there are now waits every Friday, Saturday and Sunday - due to the capacity restraints.“Guests are going to get tired of that, and what else is that going to do? It allows us to employ less people due to limited capacity,” Morton said.The 25 percent cap will last at least another three weeks. Only then may the county become eligible for the next lower tier, which would increase the cap to 50 percent - still a struggle in an industry famous for thin margins. 1484