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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

BEIJING, April 14 (Xinhuanet) -- The discovery of a sharp-toothed dinosaur fossil in New Mexico, the United States, may bridge a gap in the evolution of the species, researchers said in Wednesday's journal Proceedings of the Royal Society B.Researchers from the Smithsonian Institution unearthed the dinosaur skull and neck vertebrae in Abiquiu, New Mexico, where it had remained buried for around 230 million years. The short snout and slanting front teeth of the find — Daemonosaurus chauliodus — had never before been seen in a Triassic era dinosaur, said Hans-Dieter Sues of the Smithsonian's National Museum of Natural History.Sues, curator of vertebrate paleontology at the museum, said the discovery helps fill the evolutionary gap between the dinosaurs that lived in what is now Argentina and Brazil about 230 million years ago and the later theropods like the famous Tyrannosaurus rex."Various features of the skull and neck in Daemonosaurus indicate that it was intermediate between the earliest known predatory dinosaurs from South America and more advanced theropod dinosaurs," said Sues."One such feature is the presence of cavities on some of the neck vertebrae related to the structure of the respiratory system," he added.The discovery suggests that there is still much to be learned about the early evolution of dinosaurs."The continued exploration of even well-studied regions like the American Southwest will still yield remarkable new fossil finds," Sues said.

BEIJING, May 16 (Xinhuanet) -- NASA has readied the space shuttle Endeavour for its liftoff set for Monday, media reported Monday.Good weather looks 70 percent likely for Monday's scheduled launch of Endeavour, the next-to-last U.S. space shuttle mission as NASA develops a new generation of craft for longer voyages."The updated forecast Sunday for Monday's launch of the shuttle Endeavour remains unchanged with a 70 percent chance of good weather," said NASA spokesman Allard Beutel.The space shuttle Endeavour STS-134 sits on launch pad 39A after the rollback of the Rotating Service Structure at the Kennedy Space Center in Cape Canaveral, Florida May 15, 2011.Liftoff is set for 8:56 a.m. EDT (1256 GMT) from the Kennedy Space Center for the trip to the International Space Station after the U.S. space agency repaired a technical glitch that canceled last month's launch attempt.The initial April 29 launch attempt was scrubbed hours before liftoff when technicians discovered a power failure in a heating line that served to prevent fuel from freezing in orbit.The six-member crew of astronauts including five Americans and one Italian, Roberto Vittori, will deliver a potent physics experiment to probe the origins of the universe during the mission, which will include four spacewalks.The 16-day mission is intended to help get the space station ready for operations after the shuttle fleet is retired. The 135th and final shuttle launch is scheduled for early- to mid-July aboard Atlantis.

CAPE CANAVERAL, Florida, April 29, (Xinhua) -- NASA on Friday delayed space shuttle Endeavor's launch to no earlier than Monday afternoon due to technical problems with heaters in the shuttle's auxiliary power unit."Shuttle Endeavor's launch now no earlier than Monday at 2:33 p. m. EDT (1833 GMT)," NASA said. "Engineers need that time to troubleshoot an issue that resulted in today's launch scrub."During Friday's countdown, engineers detected a failure in one of two heater circuits associated with Auxiliary Power Unit (APU) 1. Heaters are required to keep the APUs' hydrazine from freezing on orbit.Space shuttle Endeavour sits on the launch pad at the Kennedy Space Center at Cape Canaveral, Florida,  April 28, 2011. The Endeavor is scheduled for a Friday afternoon launch.U.S. President Barack Obama, touring storm damage in Alabama on Friday, had been expected to attend the planned 3:47 p.m. (1947 GMT) launch. Obama will still visit Cape Canaveral and then travel to Miami, where he is scheduled to speak at a community college commencement.Endeavor's 14-day mission will deliver the Alpha Magnetic Spectrometer-2 (AMS) to the International Space Station. AMS, a particle physics detector, is designed to search for various types of unusual matter by measuring cosmic rays.Its experiments are designed to help researchers study the formation of the universe and search for evidence of dark matter, strange matter and antimatter. Endeavor also will fly the a platform that carries spare parts that will sustain space station operations once the shuttles are retired from service.The mission will feature four spacewalks to do maintenance work and install new components. These are the last scheduled spacewalks by shuttle crew members.Endeavor, which has been promised to the California Science Center in Los Angeles upon its return, was the replacement ship for Challenger, which was lost in a 1986 explosion as it ascended over the Atlantic that killed seven astronauts.It will be the second of NASA's three surviving shuttles to be retired. Sister ship Discovery, which will be transferred to the Smithsonian National Air and Space Museum, completed its last flight in March.Atlantis' final launch is scheduled for June 28. When the U.S. space shuttle program officially ends later this year, the Russian space program's Soyuz capsule will be the only method for transporting astronauts to and from the station.

BEIJING, Jan. 27 (Xinhua) -- A senior Chinese official has called on the country's religious figures to make more contributions to economic and social development by innovating and improving social services.Jia Qinglin, a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, made the remark at a meeting Thursday while offering lunar New Year's greetings to religious circles on behalf of the CPC Central Committee.Jia Qinglin (front, R), chairman of the National Committee of the Chinese People's Political Consultative Conference (CPPCC), and a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, shakes hands with one of the leaders of the religious groups during an informal discussion sponsored by CPPCC in Beijing, capital of China, Jan. 27, 2011, to celebrate the upcoming Spring Festival.Jia said Chinese citizens' freedom in religious belief was fully protected, and the religious circles had provided excellent services for people from around the world during the Shanghai World Expo and Guangzhou Asian Games last year.The official asked the religious circles to pay more attention to helping grassroots religious groups and believers and improving their management.

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