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JUPITER, Fla. — Groundbreaking research out of the Scripps Research Institute in Jupiter, Florida found a genetic explanation for the pain processing and sensory issues some children living with autism face."To see the biology in the lab turn out that has parallels to what’s going on in these children takes it so far beyond just an academic endeavor," said Dr. Gavin Rumbaugh, a neuroscientist at Scripps. "You go home every day thinking, unbelievably, I may actually be making a difference in someone's life."One of those children who Rumbaugh hopes to help with his research is 10-year-old Beckett, who lives in Texas."We wanted to understand generally in the lab how genes like SYNGAP1 affect the way the brain functions and we thought what better way was then to look and see how this gene may directly affect sensory processing, and then further on ask the question, 'Does the change in sensory processing actually lead directly to learning, memory and behavioral impairment?' " he said.Beckett has a genetic mutation of SYNGAP1, which researchers have now found causes certain issues he faces, particularly, having an extremely high pain threshold while also experiencing heightened sensitivity to another kind of stimuli. Beckett and other children living with this genetic mutation also often have epilepsy."It's all about quality of life. Everybody deserves to live their best life and that's my mission," said Monica Weldon, Beckett's mom.Weldon said the research being done in Jupiter could change her son's life and the lives of hundreds of other children around the world with the same genetic abnormality and symptoms, some of whom whose families she's connected with online."That is the power I believe of a patient group that is motivated to find treatments for their loved ones," Weldon said. "Also, you've got scientists who are listening. They're willing to listen and they're willing to learn."The next step in Rumbaugh's research is to look at treating the symptoms from the genetic mutation. 2043
Known as the Green Mountain State, Vermont’s bucolic natural beauty offers a sharp contrast to the reality facing some of its residents.“The room you're in here would be busy all day,” said Gary De Carolis, executive director of the Turning Point Center in Burlington, the state’s largest city.Normally, 3,000 people would come to that addiction treatment center each month.“Then, the pandemic hit and, of course, everything just went; everyone just retreated to their homes,” De Carolis said. “And we know that the enemy of recovery is isolation.”The most recent stats available from the state’s Department of Health, from April, show Vermont had 47 opioid-related deaths, which is an increase over the 38 overdose deaths seen at the same time last year.In addition, compared to April of last year, the rate of nonfatal opioid overdoses doubled from 14 percent to 36 percent.Nationwide, the American Medical Association said nearly 40 states have seen spikes in opioid overdoses since the pandemic began.“There is no question that the current COVID pandemic does increase risk factors that we know, even in typical times, are risk factors for overdose, more drug use,” said Dr. Patrice Harris of the American Medical Association.Those risk factors included not having regular access to health care providers and a disconnect from normal routine and community, especially when in-person addiction treatment centers closed all over the country.That’s where telehealth stepped in, up to a point.“However, let's note there that if you didn't have a data plan or phone or computer or access to even broadband, then you weren't able to take advantage of that,” Dr. Harris said.Back in Burlington, via phone calls or Zoom meetings, the Turning Point Center is seeing about 500 clients a month, a fraction of what they would normally see, but no less needed.“Until we have a vaccine, I don't think it'll ever be business as usual,” De Carolis said. “One day at a time, as they say.” 1983

KALAMAZOO, Michigan (AP) — The first trucks carrying a COVID-19 vaccine for widespread use in the United States have pulled out of a Michigan manufacturing plant. The shipments Sunday morning set in motion the biggest vaccination effort in American history. The shots that are critical to stopping the nation’s coronavirus outbreak are destined to reach states a day later. Initial doses of the Pfizer vaccine will likely be limited to health workers and nursing home residents. The Food and Drug Administration authorized emergency use of the vaccine Friday, saying it is highly protective and presents no major safety issues. 635
LA JOLLA, Calif (KGTV) - A La Jolla man is turning recycled plastic into stuffed animals to help teach kids the importance of protecting the ocean.Malte Niebelschuetz created the "Shore Buddies" in 2014. He started with four animals: Steven Seagull, Sammy the Seal, Emma the Whale and Fin the Dolphin. Now, he's running a Kickstarter campaign to help create a new doll, Shelly the Sea Turtle. He's also hoping to publish a children's book that he wrote starring the animals."The kids, they are our future," he says. "They will shape this planet into a plastic-free society."The stuffed animals are made out of recycled plastic. Each animal uses six plastic bottles. Niebelschuetz says the plastic is broken down into a fiber, which is then turned into yarn."In just four years, we've kept more than 100,000 plastic bottles out of the ocean and turned them into fluffy, cute Shore Buddies," he says.Neibelschuetz is taking the dolls and book to schools across San Diego. He reads to the classes and teaches the kids how to keep plastic out of the ocean.Recently, he read at La Jolla's Gillispie School. The school has a "Big Project" going on that gets kids from Kindergarten to 6th grade engaged in issues that affect the community. One of them is human effects on the coastline."I truly believe in being the change you want to see in the world," says Niebelschuetz. "If that means that whenever you go to the beach you pick up three pieces of plastic, that's a start."The only way to get the book or any of the stuffed animals right now is through the Shore Buddies Kickstarter campaign. You can access it here. 1621
JACKSON, Miss. (AP) — A group recommending a new Mississippi state flag has chosen five final designs — three with a magnolia blossom, one with a magnolia tree and one with a shield that has wavy lines representing water. Mississippi legislators recently retired the last state flag with the Confederate battle emblem that’s condemned as racist. By law, the new design cannot have the Confederate emblem and must have “In God We Trust.” Mississippi was the 20th state, admitted into the Union in 1817, but the finalist designs have 21 stars to include the Mississippi Band of Choctaw Indians and other indigenous people.After getting hundreds of submissions, the flag comission narrowed the field to nine designs and asked the public to weigh in via an online vote. Commission Chairman Reuben Anderson noted Tuesday that more than 48,000 people voted, according to MississippiToday.com.“That shows Mississippians have a tremendous amount of interest in what we’re doing,” Anderson said. “We’re not going to disappoint them. We will put forth the greatest flag we can have.”The five final designs will be made into flags, and those will be flown Aug. 25 in Jackson. The Mississippi Flag Commission will decide on a single flag design in early September to put on the November ballot. 1291
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