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2025-05-28 04:28:49
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  濮阳东方妇科很专业   

WASHINGTON, May 20 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Friday approved Sutent to treat patients with progressive neuroendocrine cancerous tumors located in the pancreas that cannot be removed by surgery or that have spread to other parts of the body.Neuroendocrine tumors found in the pancreas are slow-growing and rare. It is estimated that there are fewer than 1,000 new cases in the United States each year.This is the second new approval by the FDA to treat patients with this disease. On May 5, the agency approved Afinitor."FDA believes it is important to provide cancer patients with as many treatment options as possible," said Richard Pazdur, director of the Office of Oncology Drug Products in the FDA's Center for Drug Evaluation and Research. "The agency is committed to working with companies to bring innovative new therapies to the market and encourages companies to continue exploring additional uses for approved products."The safety and effectiveness of Sutent was established in a single study of 171 patients with metastatic (late-stage) or locally advanced (disease that could not be removed with surgery) disease who received Sutent or a placebo (sugar pill). The study was designed to measure the length of time a patient lived before their disease spread or worsened (progression-free survival).Results from the study demonstrate that Sutent provided benefit to patients by prolonging the median length of time they lived without the cancer spreading or worsening to 10.2 months compared to 5.4 months for patients who received placebo.In patients treated with Sutent for neuroendocrine pancreatic tumors, the most commonly reported side effects included diarrhea, nausea, vomiting, fatigue, anorexia, high blood pressure, energy loss, stomach pain, changes in hair color, inflammation of the mouth, and a decrease in infection-fighting white blood cells.Sutent is marketed by New York City-based Pfizer.

  濮阳东方妇科很专业   

LOS ANGELES, May 1 (Xinhua) -- Middle-aged adults who sleep too less or too much may be more likely to suffer cognitive decline, a new study suggests.According to the study, less than six hours of sleep each night is considered too little and more than eight hours as too much for middle-aged adults.The study, conducted by researchers at University College London Medical School, was published May 1 in the American medical journal Sleep.The researchers conducted the study in two periods -- the 1997- 1999 period and the 2003-2004 period. The participants were asked how many hours they slept on an average week night, and were asked the same question in 2003-2004 after an average 5.4 years of follow-up.The researchers compared those who reported changes in their sleep patterns with people whose sleep duration stayed the same over the course of the study.In the follow-up, each individual was given a battery of standard tests to assess his or her memory, reasoning, vocabulary, global cognitive status and verbal fluency.The study findings show that women who slept seven hours per night had the highest score for every cognitive measure, followed by those who had six hours of sleep. For men, cognitive function was similar for those who reported sleeping six, seven or eight hours.However, less than six hours of sleep -- or more than eight hours -- were associated with lower scores."Sleep provides the body with its daily need for physiological restitution and recovery," explained Jane Ferrie, a senior research fellow in the department of epidemiology and public health at the school. "While seven hours a night appears to be optimal for the majority of human beings, many people can function perfectly well on regular sleep of less or more hours."However, since most research has focused on the effects of sleep deprivation on biological systems, it is not yet fully understood why seven hours is optimal -- or why long sleeping appears to be detrimental, Ferrie said."Chronic short sleep produces hormones and chemicals in the body which increase the risk of developing heart disease and strokes, and other conditions like high blood pressure and cholesterol, diabetes and obesity," she added.

  濮阳东方妇科很专业   

WASHINGTON, April 11 (Xinhua) -- In the first clinical trial of gene therapy for treatment of intractable pain, U.S. researchers from the University of Michigan's Department of Neurology observed that the treatment appears to be able to provide substantial pain relief.In a study published online in the Annals of Neurology and seen on Monday, the researchers showed that the novel agent NP2 is safe and well-tolerated. In addition, measures of pain in the treated patients suggested that NP2 may provide a substantial analgesic effect.NP2 is a gene transfer vector that expresses the naturally- occurring opioid peptide enkephalin. In preclinical work in animals, David Fink, chair of the Department of Neurology, and his coworkers had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation or cancer.In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain."The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," says Fink. "In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of four weeks following treatment."Fink's laboratory has been working on the use of modified herpes simplex virus-based vectors that are taken up by sensory nerves following skin injection to develop therapies for diseases of the nervous system for more than 20 years. Patents related to this technology have been exclusively licensed by Diamyd Medical, a publicly-traded Swedish biotechnology company that sponsored the trial, and the human-grade vector NP2 was produced by Diamyd, Inc, the U.S. subsidiary of Diamyd Medical.A phase 2 trial to compare NP2 to a placebo control has already been initiated under sponsorship from Diamyd.

  

GUIYANG, Jan. 23 (Xinhua) -- Migrant workers, or off-farm workers, in China should enjoy paid annual family-visit vacations as their urban counterparts, a political advisor in southwest China's Guizhou Province had said."Localities could legislate on the issue on a trail basis," said Yu Peixuan, a member of the Guizhou Provincial Committee of the Chinese People's Political Consultative Conference (CPPCC), made this proposal at the political advisory body's annual session held Jan. 16-22.If migrant workers took paid home leave every year, they would have more time to help their wives in rural homes do the heavy farm work and educate their children, said Yu. "Thus, family ties would be cemented."Statistics show that 47 million women remain at home in rural China when adult males go off to cities to earn their livings.These women played an important role in taking care of the elderly people and children in their rural homes, but they also face many practical difficulties, such as heavy farm work and dull daily life.One of the major factors affecting these women's quality of life was the lack of communications with their husbands, said Yu.Yu called on large enterprises to allow migrant workers to take paid home leave first to set an example for other enterprises.According to the present Labour Law, regular workers at government organs, institutions and state-owned enterprises are eligible for paid vacations of one month per year to visit separated spouses in different cities or regions.

  

BEIJING, Feb. 24 (Xinhua) -- Graft remains one of the Chinese people's top concerns, as indicated by online polls from two mainstream media in China prior to the country's annual parliamentary and political advisory sessions.As of 9 p.m. on Thursday, over 54,000 Internet users voiced their concerns over "the fight against corruption and efforts to build a clean government" in an online survey launched by the Xinhua News Agency.Corruption came in at fourth place behind "curbing housing prices," "income distribution" and "control of commodity prices."The poll was launched by Xinhua and was meant to solicit public opinion ahead of the annual sessions of the National People's Congress (NPC) and the National Committee of the Chinese People's Political Consultative Conference (CPPCC).In a survey posted on People.com.cn, a website subsidiary of the People's Daily newspaper, "anti-graft" was among the most selected topics following "social security" and "judicial justice."Internet users pinned their hopes on the forthcoming parliamentary and political advisory sessions, which are scheduled to open in early March.They hope that their voices would be heard by the country's lawmakers and political advisors, who would represent them in the two sessions and would take all possible measures to tackle a number of social issues including the fight against corruption."I hope that the Central Committee of the Communist Party of China (CPC) combats graft comprehensively and severely to ensure a Party with a clean work style, a society with justice and assures the Chinese people that they would not be wronged," said an Internet user from Jiangxi province in a forum entitled "voicing my wishes to Premier Wen Jiabao at the 2011 two sessions " on xinhuanet.com.Internet users believe that the spread of corruption in some places had hindered China's economic development, undermined social stability and harmed the relationship between the people and officials.The fight against corruption, therefore, is a significant factor in determining whether or not China can reach its goals outlined in its Twelfth Five-year Program (2011-2015) on National Economic and Social Development, an Internet user wrote."Corruption has affected Chinese people's life through its spread into many social sectors. As the two sessions represent an open platform to reflect the people's will, citizens hope to push forward the cause of anti-corruption through legislation, thus addressing their common concerns." said Ren Jianmin, director of the Anti-corruption and Governance Research Center of Tsinghua University.The CPC has never relaxed its efforts to fight against corruption, experts say.Last year saw four ministerial-level Chinese officials placed under a graft probe or removed from their posts. Among these officials were Zhang Jiameng, former vice chairman of the Zhejiang Provincial People's Congress Standing Committee in southeast China, and Zhang Jingli, former deputy director of the State Food and Drug Administration.Another 11 ministerial-level officials were sentenced to life imprisonment or other severe punishments in 2010.On February 12 this year, Liu Zhijun, the Chinese Minister of Railways, was removed from his post as the Party chief of the ministry over an alleged "severe violation of discipline," becoming the latest senior official to be investigated in the country's battle against corruption.Experts believe that the downfall of high-ranking officials over corruption charges have clearly shown the determination of the CPC to enforce the Party's discipline, combat corruption and promote a clean work style.On January 10 this year, Chinese president Hu Jintao called for efforts to tackle prominent problems that have seriously harmed people's interests and sparked most public complaints during a plenary session of the CPC Central Commission for Discipline Inspection (CCDI), the Party's anti-graft body.He also pledged to combat graft and punish corrupt officials severely to win the trust of the people.Further, the CPC's drive to erase corruption yielded significant results last year.A total of 5,098 leaders at the county level or above have been punished and 804 officials were referred for prosecution last year, said Gan Yisheng, the deputy secretary of the CCDI, on January 6 this year.Despite the achievements accomplished by the CPC in its fight against corruption, Ren Jianmin believes that the anti-graft situation in China is grave and the task remain arduous.Problems concerning land acquisition and compensation, housing, food and drug safety, environmental protection, work place safety and equal access to education have been reported by the public.To handle these issues, CCDI secretary He Guoqiang urged officials on January 12 to "put people first" and "exercise the state's power for the people" when addressing problems that the public complains about.He, also a member of the Standing Committee of the CPC Central Committee Political Bureau, said that efforts should be enhanced to fight graft in fields that are most vulnerable to corruption and unhealthy practices."The two sessions have a special role to play in China's fight against corruption," said Li Chengyan, a professor at the School of Government in Peking University."Every year, the Party and the government will take effective measures after the two sessions, as a response to social concerns. The people and the media's focus on anti-graft work will push the government to solve relevant problems," he said.According to experts, however, what's more important is to put in place a sound system concerning anti-corruption, promote reform and ensure the implementation of existing measures.

来源:资阳报

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