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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — Continuing its success breeding the first southern white rhino through artificial insemination, the San Diego Zoo Safari Park welcomed a second rhino to the mix last week.The unnamed female rhino was born on Nov. 21 just after midnight at the zoo, becoming the 100th southern white rhino born overall at the Safari Park.The rhino's mother, 11-year-old Amani, gave birth to the calf at the park's Nikita Kahn Rescue Center, where she did extremely well during labor and is now bonding with the new calf, the zoo says.RELATED: San Diego Zoo's baby southern white rhino charges into life at the parkThe rhino is the second southern white rhino born via hormone-induced ovulation and artificial insemination in North America. The first rhino, Edward, was born at the park on July 28.“We are so excited to welcome another healthy calf to the rhino crash at the Nikita Kahn Rhino Rescue Center,” said Barbara Durrant, of San Diego Zoo Global. “We are very pleased Amani did so well with the birth of her first calf, and she is being very attentive to her baby. The calf is up and walking, and nursing frequently, which are all good signs. Not only are we thankful for this healthy calf, but this birth is significant, as it also represents a critical step in our effort to save the northern white rhino from the brink of extinction.”Southern white rhinos are designated as "near threatened" on the International Union for Conservation of Nature Red List of Threatened Species. There are an estimated 18,000 southern white rhinos left in the wild.San Diego Zoo hopes that the science used to successfully breed the southern white rhino lead to the genetic recovery of the subspecies northern white rhino, of which only two remain on the planet and are females. Once the science is perfected, the zoo says southern white rhinos could serve as surrogates for embryos of their northern counterparts. RELATED: Birth of baby rhino marks major milestone in effort to save critically endangered species“We believe in the importance of this work because it has the potential to be applied to save other wildlife, including the critically endangered Sumatran and Javan rhinos," said Paul Baribault, CEO of San Diego Zoo Global. While the science is complex, zookeepers hope to see a northern white rhino born in 10 to 20 years. 2338

SAN DIEGO (KGTV) -- California state officials have issued their COVID-19 guidelines for gathering during the holidays. With less than two weeks until Thanksgiving, the guidelines include things like physical distancing and wearing a mask when not eating or drinking. There are specific guidelines for counties in the purple tier, like San Diego County. Counties in the purple tier are required to gather outdoors. Health officials recommend no more than three households and limiting the gathering to two hours or less. Infectious disease specialists say the guidelines are strict, but necessary to slow the spread of the virus. Other recommendations include having guests frequently wash their hands and having only one person serve food and beverages, with a mask on. Older and at-risk individuals are advised not to attend. To read the full list of recommendations click here. 889

SAN DIEGO (KGTV) — Breakfast and brunch aficionados will soon have a whole new reason to flip over the most important meal of the day. "Flap Your Jacks" is bringing its own take on the traditional breakfast dish to North Park later this summer. The eatery will take over 3020 University Ave. with a bright, modern space featuring a custom art installation of "thousands" of spatulas hanging from the ceiling and a syrup-topped stack of "pancakes" on the building's facade.RELATED: 9 San Diego restaurants named most scenic in AmericaA menu packed with breakfast and brunch favorites will be offered from the kitchen, in addition to several freshly-squeezed juice options, "energy shots," and signature cocktails to jump start the day. But perhaps the most fun will be found in the breakfast joint's unique approach to pancakes, which guests can customize on their own.Each table will be outfitted with a personal griddle, inviting guests to put on their own chef hat and create their favorite pancakes from a variety of homemade batter flavors and toppings. The interactive concept aims to not only bring a new level of creativity to breakfast but also a unique conversation piece.RELATED: Puesto to move into Gordon Biersch's Mission Valley location this summer(Plus the chance to wow your friends with your pancake making skills.)But for those less confident in their flipping abilities, there are still several options, including pancakes, available from the kitchen.The two-level restaurant will be open daily from 7 a.m. to 3 p.m. once it opens. Currently, owners hope to debut Flap Your Jacks in late September or early October. 1642

SAN DIEGO (KGTV) -- Chula Vista city officials have placed the controversial statue of explorer Christopher Columbus in storage "out of public safety concerns."City spokeswoman Anne Steinberger said the bronze statue was removed early Friday morning from its platform at Discovery Park in the Rancho Del Rey neighborhood.The Columbus statue has been at the park on 700 Buena Vista Way for nearly three decades, but it has been a frequent target of vandals. Last Columbus Day, the statue was doused with red paint.The city had been hearing arguments for and against the removal of the statue with many people -- including local Native American tribes -- calling the sculpture a symbol of hate, theft of land, and genocide. The debate became heated Feb. 26 when representatives from both sides faced off in a Chula Vista Human Relations Commission meeting. The fiery session prompted Chula Vista police to respond.At the meeting, Chula Vista City Councilman John McCann, with members of the Knights of Columbus standing by his side, called for the statue to be left alone.VIDEO: San Diego man verbally attacked during woman's racist rantThe following night, the committee voted unanimously in favor of a proposal that includes the removal of the statue. The approved a resolution has been postponed due to the coronavirus pandemic."Due to restrictions related to coronavirus, there has not been an opportunity to hold a public forum for community dialogue," said Steinberger. "It is expected that the item will be brought forward for further public input and consideration."It's unclear how long the statue will remain in storage or if the city has decided it will remain there permanently. In a statement regarding its removal, City Councilman Steve Padilla said, "Many have asked for its removal, and given all that is happening nationwide regarding America’s legacy of racism, the City decided to put it in storage.""I look forward to an important community conversation about the final fate of the statue, as well as further actions the City can take to ensure that ALL Chula Vistans feel safe and welcome in our community," said Padilla.The city's decision to stow the statue comes amid national-turned-global Black Lives Matter protests against racism and police brutality stemming from the in-custody death of a black man, George Floyd, who died after a Minneapolis police officer knelt on his neck as he begged for air.READ: 8 Books To Teach Kids About Racism And Social JusticeIn response to call for racial justice, various cities and institutions have taken steps to eradicate symbols honoring controversial figures including public statues of Confederate soldiers. This last week, Nascar and the U.S. Marine Corps announced a ban on public displays of the Confederate battle flag.Demand for action has even extended to Disney. A petition posted on Change.org asks that company remove all references to its 1946 film "Song of the South" from the water ride Splash Mountain. 2994