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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

BEIJING, Dec. 30 (Xinhua) -- China will push to properly resolve the case of a Chinese skipper indicted by Japan, the Foreign Ministry said Friday.Spokesman Hong Lei said this is a common fishing case, and the Chinese embassy in Japan has dispatched officials to visit the skipper.China requests that Japan ensure the rights of the Chinese skipper, Hong said, and China is communicating closely with Japan in order to properly resolve the case.The Chinese government has been requiring fishermen to fish legally, Hong said, adding that the competent authorities have done a lot in this area, and he promised to promote the management and education of Chinese fishermen.Japanese prosecutors have indicted the captain of a Chinese fishing boat for illegally operating in Japanese waters, a local official said Friday.The Nagasaki District Public Prosecutors Office has finalized its case against Zhong Jinyin, 39, following his December 20 arrest near islands off southwest Japan, according to the official.The prosecutors have not indicated whether the skipper has admitted to the charge.

YICHANG, Oct. 30 (Xinhua) -- China's Three Gorges Dam on Sunday reached its designed highest mark, the second time for the world's largest water control and hydropower project to run at full capacity.The water level hit 175 meters at 5 p.m. after storing water for nearly two months from the water level of 152 meters, said an official with the China Three Gorges Project Corporation (CTGPC), the developer of the project.A dozen hydropower turbo-generator units started operation on Sunday, generating power capacity of 8.2 million kw, said the official.The dam in central China's Hubei Province completed its first full-capacity test last October.Operating at full capacity should give full play to the dam's functions of generating hydroelectric power, delivering water to the lower reaches to alleviate spring droughts, and containing water from summer flooding, as required by the State Flood Control and Drought Relief Headquarters.The Three Gorges Project was launched in 1993 with a budget equivalent to 22.5 billion U.S. dollars.So far, monitoring shows the dam is operating smoothly.

BEIJING, Jan. 1 (Xinhua) -- President Hu Jintao, along with other Chinese leaders, celebrated the New Year with political advisors Sunday morning in Beijing and delivered an important speech.Hu and the other members of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee Wu Bangguo, Wen Jiabao, Jia Qinglin, Li Changchun, Xi Jinping, Li Keqiang, He Guoqiang and Zhou Yongkang attended a tea party held by the National Committee of the Chinese People's Political Consultative Conference (CPPCC).

BEIJING, Jan. 24 (Xinhua) -- China's meteorological authority said Tuesday that the country's northern regions will continue to have sunny weather for the coming 24 hours, while the south will see subdued rain and snow.Temperatures in most parts of the country are expected to rebound slightly, the National Meteorological Center said in a statement on its website.But the lowest temperatures in the areas south of the Yangtze River will remain around zero degree Celsius, the center said.Meanwhile, rain and snow will subdue in most parts of the southern regions over the next three days, although freezing rain is forecast to hit Guizhou and Hunan provinces, according to the statement.

来源：资阳报