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WASHINGTON, Nov. 7 (Xinhua) -- U.S. researchers have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans.The findings, published Monday in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes."The brain is the body's only organ that needs a constant supply of glucose to survive, so it makes sense that it would have some say over how much glucose is produced," said study leader Meredith Hawkins, professor of medicine and director of the Global Diabetes Initiative at Yeshiva University, in a statement. "This role for the brain was demonstrated in earlier studies in rodents, but there was considerable controversy over whether the results could be applied to humans. We hope this study helps to settle the matter."In an earlier study in rodents, researchers showed that activation of potassium channels in the brain's hypothalamus sends signals to the liver that dampen its production of glucose. Those findings, published in Nature in 2005, challenged the conventional thinking that blood sugar production by the liver (the body's glucose factory) is regulated only by the pancreas (which makes insulin to metabolize glucose). But carefully performed studies on dogs, conducted at Vanderbilt University, failed to replicate the results, suggesting the Einstein findings in rodents might not be relevant to higher mammals, including humans.The current study, involving people, was aimed at resolving this controversy. Ten nondiabetic subjects were given oral diazoxide, a drug that activates potassium channels in the hypothalamus. (The drug is not used to treat diabetes.) Hormone secretion by the pancreas was controlled to ensure that any change in sugar production would only have occurred through the drug's effect on the brain. After the researchers administered the drug, blood tests revealed that patients' livers were producing significantly less glucose than before.Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results. They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus. Additional experiments confirmed that diazoxide was working through the brain. Specifically, the researchers were able to completely block the effects of diazoxide by infusing a specific potassium channel blocker directly into the brain."This study confirms that the brain plays a significant role in regulating glucose production by the liver," said lead author Preeti Kishore, assistant professor of medicine. "We are now investigating whether this 'brain-to-liver' pathway is impaired in people with diabetes. If so, we may be able to restore normal glucose regulation by targeting potassium channels in the brain."

NEW DELHI, Oct. 1 (Xinhua) -- Suspected encephalitis has killed over 100 children in the northern Indian state of Bihar since June, reported local media Saturday.At least 51 children in Bihar's Gaya district died of the epidemic in the last seven weeks, in the wake of the death of 55 children in a similar outbreak of the brain disease in another district of the state earlier, reported Indo-Asian News Service.Most of the children belong to a caste known for its absolute poverty.According to district health officials, all children have died at Anugrah Narain Medical College and Hospital in Gaya, about 100 km from the state capital Patna.The children reported high fever, followed by bouts of unconsciousness and convulsions.So far, more than 220 children with suspected encephalitis were admitted for treatment, with over two dozens of the children still battling for life, according to the report.Earlier, Indian Health and Family Welfare Minister Ghulam Nabi Azad has said clinical and epidemiological data suggested that there was an outbreak of acute encephalitis syndrome, resulting in 150 cases and 55 deaths, mostly among children, from early June to mid-July in the Muzaffarpur district of Bihar.

SAN FRANCISCO, Nov. 17 (Xinhua) -- Online retail giant Amazon is working on a smartphone scheduled to be released in the fourth quarter of 2012, U.S. media reported Thursday.A note from Citigroup analyst Mark Mahaney obtained by technology news site All Things Digital said that based on the supply chain checks in Asia, Amazon is believed to launch a smartphone in the fourth quarter of 2012.According to the note, Amazon is working with manufacturer Foxconn and the device will run Texas Instruments' OMAP 4 processor. The Kindle Fire, the latest tablet introduced by the e- commerce giant, also uses OMAP processor.The analyst said the smartphone will cost Amazon between 150 and 170 U.S. dollars to build and the company could sell the handset at or near its cost rather than a 30 percent gross margin like many other smartphone manufacturers usually do.The move is expected to further intensify Amazon's rivalry with Apple and Google after the e-commerce giant had made moves on some booming businesses like tablet computer and cloud-computing service.

BEIJING, Jan. 6 (Xinhua) -- Surveillance data on the size and frequency of earthquakes in Antarctica collected by China's Great Wall Station show that the continent is not earthquake-free, a Chinese seismic expert said Thursday."China's newly-built seismic observatory in Great Wall Station has documented a hundred-odd earthquakes occurring in the region over the past year," said Chang Lijun, a member of China's 28th Antarctic expedition team.The discovery challenges the prevailing notion that the Antarctic has no earthquakes, as many earthquakes have gone undetected due to lack of seismological observation in the region.However, thanks to technological advances, scientists have discovered that the continent is still subject to some minor tremors.Chang, also an associate researcher at China Earthquake Administration's Geophysics Institute, said last year's earthquakes ranged in magnitude from 0.5 to 4, scales which are usually undetectable to common people.The tectonic movements of Antarctica, which sits on two plates that pulled away from each other in the northern Ross Sea between 28 and 40 million years ago, but later converged, fascinate geologists worldwide.At the end of 2010, Chinese scientists set up a new broadband seismic observatory in Great Wall Station, greatly increasing China's ability to measure tremors and tectonic movements on the continent.

BALI, Indonesia, Nov. 19 (Xinhua) -- Leaders of China, Japan and South Korea met here Saturday to exchange views on trilateral cooperation and regional and international issues of common concern.Chinese Premier Wen Jiabao, Japanese Prime Minister Yoshihiko Noda and South Korean President Lee Myung-bak were meeting on the occasion of a series of meetings for East and Southeast Asian leaders in this Indonesian resort city on Friday and Saturday.Speaking at the meeting, Wen said the cooperation between the three nations currently had good momentum, which was not only in line with the interests of the three sides but also contributed to the stability and development of the Asia and the world.Chinese Premier Wen Jiabao (L), Japanese Prime Minister Yoshihiko Noda (C) and Republic of Korea (ROK) President Lee Myung-Bak pose for photos during the Trilateral Summit Meeting for leaders of the three nations in Bali, Indonesia, Nov. 19, 2011.As the coordinator of next year's China-Japan-South Korea cooperation, China would like to further enhance high-level exchanges, policy coordination and strategic trust between the three countries, providing political impetus and promoting more advancement in trilateral cooperation, Wen said.He said next year marked the 40th anniversary of the normalization of diplomatic relations between China and Japan, and the 20th anniversary of the establishment of diplomatic relations between China and South Korea.In the meeting, Wen proposed the joint research into a free trade area between the three countries be completed this year, and negotiations start in 2012.Wen also suggested enhancing trilateral cooperation in the fields of transportation, finance and environmental protection, among many others.Also speaking at the meeting, the Japanese prime minister and the South Korean president said the cooperation between the three nations had seen remarkable achievement and its prospects were promising.The three sides should continue to deepen their exchanges and cooperation in various fields including economy and trade, finance, investment, disaster relief, culture, education and tourism, and strengthen the coordination in regional and international issues to promote common development, according to them.During the meeting, the three leaders also exchanged views on other regional and international issues of common concern.