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SAN DIEGO (CNS) - A pickup truck struck and gravely injured a 70-year-old man today near Horton Plaza, authorities reported.The pedestrian was crossing G Street in downtown San Diego when the vehicle pulled out of a parking structure east of Third Avenue and hit him shortly after 3 p.m, according to police.Medics took the victim to a hospital for treatment of life-threatening injuries, Officer Dino Delimitros said. 426

SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - Customs and Border Protection agents, along with the U.S. Coast Guard, intercepted two smuggling boats, arrested six people and seized roughly 528 pounds of methamphetamine and 941 pounds of marijuana off the coast of San Diego over the weekend, authorities reported Tuesday.The first apprehension happened around 1:10 a.m. Saturday, when agents detected a panga-style boat traveling northbound off the San Diego coast, according to CBP officials. The U.S. Coast Guard Cutter Forrest Rednour helped CBP agents chase down the boat, which was eventually halted around 12 nautical miles west of Oceanside when agents fired shots into the suspects' engine.Agents arrested four people from the roughly 28-foot boat and seized 528 pounds of methamphetamine.The second seizure happened shortly before 3:30 p.m. Saturday, when the crew on U.S. Coast Guard Cutter Haddock responded to a report of a suspicious vessel and boarded a fishing boat that was docked at the San Diego Bay channel.CBP agents also responded to the vessel and found two people who did not have proper documentation to be in the United States. The agents took the two into custody and towed the boat to U.S. Coast Guard Sector San Diego, where a canine team allegedly found 941 pounds of marijuana wrapped in cellophane packages in the boat's center console. 1347

SAN DIEGO (CNS) - A North Carolina man who raped and murdered a 79- year-old woman in her Normal Heights home more than three decades ago was sentenced Friday to life in prison without the possibility of parole. Kevin Thomas Ford, 63, was convicted by a San Diego jury last month for the May 20, 1987, murder of Grace Hayden, who was strangled and smothered during the rape, according to Deputy District Attorney Valerie Summers. The prosecutor said Ford worked as a driver for older medical patients in San Diego and had driven Hayden two days before her body was found on the floor of her bedroom. DNA on the victim's body, as well as a fingerprint found on her stovetop led to Ford's 2018 arrest in North Carolina. Jurors deliberated for about five hours before convicting Ford of murder and special circumstance allegations of murder in the commission of rape and murder in the commission of a burglary. RELATED: Testimony wraps in trial of 1987 rape, murder of Normal Heights womanFord claimed to have had consensual sex with Hayden on or around the day she was killed, but maintained at trial and the sentencing hearing that someone else killed her after he left her home. At Friday's sentencing, Ford addressed the court, saying he sympathized with Hayden and her family and couldn't imagine if something similar had befallen his mother or grandmother. ``I can't imagine what it's like, having to go through what Grace Hayden went through. It must have been a night of sheer terror,'' Ford said. “But the police got the wrong man. Whoever did this is either dead or still running around free. I didn't do it. God knows I didn't do it.'' San Diego County Superior Court Judge Louis R. Hanoian expressed his disappointment with Ford's denial of the crime, calling the killing ``despicable'' and ``heinous,'' prior to imposing the life without parole sentence. ``You have to be the most unlucky person on the planet, maybe the most unlucky person who has ever lived on this planet, to have supposedly engaged in consensual sexual intercourse with a 79-year-old invalid woman, left your biological material in her, and then within -- 12 hours? -- that woman is found dead as the result of a rape murder that you didn't do?'' Hanoian said. ``The jury didn't believe it. I didn't believe it. I don't believe it.'' RELATED: Man pleads not guilty in 1987 rape, murder of San Diego womanSummers told jurors in her closing argument that injuries to Hayden's face and the back of her head indicated a ``horrible struggle.'' The victim asphyxiated from a dislodged lower denture, which is believed to have come loose during the attack. ``The final moments of this woman's life, which should have been in peace, were violent, sexually violent, and just nothing but pure terror,'' the prosecutor said. Summers said the defendant told investigators he didn't know Hayden, then testified at trial that he had lied because he didn't want to get in trouble. He also wrote a letter to his wife stating he thought he might be arrested someday, but ``I didn't know how good their evidence was,'' according to Summers, who told the jury, ``Well, now he knows, as do you.'' Summers also called Ford's claim of consensual sex a ``ridiculous story,'' particularly given Hayden's mobility issues. Defense attorney Courtney Cutter alleged the prosecution ignored the presence of a second man's DNA on vaginal swabs of the victim. The identity of the second DNA contributor remains unknown. The attorney also argued that Ford's fingerprints were nowhere else to be found in Hayden's home, not even on items the perpetrator apparently rifled through to steal, including Hayden's purse and pill bottles. 3688

SAN DIEGO (CNS) - Health officials Wednesday announced the deaths of two more residents in San Diego County due to influenza-related complications, bringing this flu season's confirmed death toll to five. A 78-year-old North County woman died earlier this month and a 70-year- old woman died in July, but both deaths were only reported last week, according to the county Health and Human Services Agency. Both women, who were not publicly identified, had no record of receiving a flu shot and both had additional medical issues, HHSA officials said. RELATED: San Diego's flu cases more than double over previous seasonThe HHSA also reported that 122 flu cases were confirmed throughout the county last week, bringing this season's total to 731 cases to date. Only 353 cases had been confirmed at this time last flu season, which the county tracks concurrently with the fiscal year that begins July 1. ``Influenza can be deadly, especially for elderly people, young children and people with compromised immune systems,'' said Dr. Wilma Wooten, the county's public health officer. ``Our condolences and sympathy go out to the families of the two women.'' County health officials and the U.S. Centers for Disease Control and Prevention strongly advise the annual flu vaccination for everyone 6 months and older, especially in demographics with a heightened risk of serious complications, such as pregnant women, people with chronic medical conditions like lung disease and people age 65 or older. RELATED: Where you can get a free flu shot in San Diego CountyResidents can take precautions against contracting the virus by frequently washing their hands, cleaning commonly touched surfaces and avoiding contact with sick people. The flu vaccine is available at local doctors' offices, retail pharmacies and the county's public health centers. A full list of locations offering flu shots can be found at the county's immunization website, sdiz.org, or by calling 211 for the county's health hotline. 2003