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As states across the country grapple with an increase in coronavirus cases and a huge demand for tests, many businesses are looking for other ways to get more mileage out of their supply chain.Like with anything else, supply and demand is a constant struggle. In this unprecedented era, the demand for things like coronavirus tests is so large that public health departments don't have a choice but to figure out ways to make our supplies last. Several states are examining pooled testing. California's Public Health Department says it's to "better leverage testing resources."Pooling is something that blood banks have used for decades to keep their blood supply safe. Dr. Claudia Cohn is the Chief Medical Officer of the AABB, formerly known as the American Association of Blood Banks.“If you have 100 people that need to be tested and if you test each of them, you’ll do 100 tests. If you find that your test is sensitive enough that you can pool together 20 samples at the same time, instead of having 100 tests, you can have five pools of 20,” Dr. Cohn said.Now, if one of those five pools is positive, then Dr. Cohn says, "You’ll need to break it out and test each of those separately. So, let’s say you have one positive person in a pool of 100 people, you either do 100 tests and find one positive or you do five pools of 20, four of those pools will be negative, so you’ve done 4 pools and covered 80 people."The test works by taking a tiny sample from each person who was tested.“When you take a swab from everyone’s nose, you isolate the DNA from that swab,” Dr. Cohn said about the PCR test, which is generally a nose swab. “It’s not a lot, it’s a small amount but it’s enough. Because these tests are very, very sensitive.”Those tests are so sensitive, and they have to be, that pooling can really only work if the test can handle, as in detect, multiple samples at once. The FDA mandates that.“The FDA is quite demanding as they should be in terms of making sure tests work well and are safe,” Dr. Cohn said.And Dr. Cohn says, pooling wouldn't work in an area where there's a large outbreak, which means a large number of people would test positive regardless of pooling. In the blood world, this strategy has been perfected.“You are taking 100 samples and taking a drop from each sample and putting it together,” Dr. Cohn said. “You are testing every single person who comes through. In the blood world safety is before everything."Blood banks test for HIV, Hepatitis C and B and well as COVID-19 antibodies, according to the American Red Cross. And, as this pandemic moves through our communities, Dr. Cohn says our blood supply needs to remain strong.“After that initial spike, it went down again and that was okay because elective surgery had been canceled, so the demand for blood had gone down as well so for a while we were at a good balance of demand and supply. But then elective surgeries opened up and hospitals went back to full service and we’re in a shortage again,” Dr. Cohn said. 3017

Authorities and the Sacramento Kings are preparing for protests that are expected Thursday after the funeral for Stephon Clark, an unarmed black man who was killed by police in his grandmother's backyard.Over the past week, the Kings have found themselves at the center of the conflict between police and outraged members of the community.Protesters have blocked the entrance to the arena on two occasions in protest over the March 18 shooting. Last Thursday, the protest forced the Kings and Atlanta Hawks to play in a nearby empty arena.On Tuesday, the doors of the arena closed as protesters arrived, again preventing fans from getting in.Sacramento police said Wednesday they are talking with team officials to plan for the Thursday game against the Indiana Pacers. Tip off is at 7 p.m. PT (10 p.m ET).Clark's funeral is scheduled to take place from 11 a.m. to 1 p.m. PT, a little more than seven miles from the NBA arena."We don't know exactly what we'll be doing. We will assess every situation as it presents itself," Sacramento Police spokesperson Sgt. Vance Chandler told CNN.In a tweet, the Kings said they are also meeting with Sacramento Mayor Darrell Steinberg and community leaders. Team officials said they "are committed to ensuring the safety and security of fans on Thursday and future events."The fatal shooting took place after Sacramento officers responded to a report that a man had broken car windows and was hiding behind a home. Police said they pursued a man -- later identified as Clark -- who hopped a fence into his grandmother's property.The officers said they shot Clark, 22, because they believed he was pointing a gun at them, police have said. Investigators only found a cell phone near his body.The officers -- one of whom is black -- have been placed on administrative leave amid a use-of-force investigation.Clark's family has disputed the police's account. 1927

Authorities have now found two packages addressed to former Vice President Joe Biden that are similar in appearance and contain potential explosive devices that resemble the others sent earlier this week to prominent critics of President Donald Trump and CNN, a law enforcement official said Thursday.The two packages, discovered at Delaware postal facilities, were removed late Thursday morning, law enforcement officials said.Earlier Thursday, a suspicious package addressed to actor-director Robert De Niro was reported at the Manhattan building where his production company is based, and its marking and contents appear similar to the other pipe bomb packages, two law enforcement sources said.The FBI said Thursday morning that the three packages are "similar in appearance to the others."A manhunt is underway for the perpetrator behind the packages. Law enforcement authorities are treating the series of bombs as a domestic terror matter and are advising the public to remain vigilant.The motive is unknown, but the recipients are all prominent targets of right-wing criticism and, in many cases, of Trump himself. The package found at CNN's New York bureau in the Time Warner Center was addressed to former CIA Director John Brennan, city and local law enforcement officials said.Devices sent to former President Barack Obama, Hillary Clinton, former Attorney General Eric Holder, California Democratic Rep. Maxine Waters and Democratic donor George Soros showed the presence of a sulfur substance, which could have exploded, a law enforcement official said.The devices are believed to be pipe bombs, inherently unstable, and at risk of being set off just by handling.The FBI's counterterrorism division is leading the investigation Thursday into the packages and the agency says it's possible additional packages were mailed to other locations.At the White House, Trump vowed Wednesday that "we will spare no resources or expense" to pursue the perpetrator. 1975

As the death toll from the Camp Fire rose to 63 people, rescue workers searching for human remains in the wreckage hope that hundreds of people who are still unaccounted for after the blaze are still alive.After going through a week of 911 calls, authorities announced Thursday they are looking into reports of 631 people who are possibly missing."You have to understand, this is a dynamic list," Butte County Sheriff and Coroner Kory Honea said Thursday evening. "Some days might be less people, some days might be more people, but my hope at the end of the day, we have accounted for everybody. "Photos: Wildfires devastation in CaliforniaA week after two major wildfires sparked at both ends of the Golden State, the total death toll has increased to 66, fire officials said.The Camp Fire -- now the deadliest and most destructive wildfire in the state -- has left 63 people dead, destroyed about 9,700 homes and scorched 141,000 acres. By Thursday night, it was 40% contained.Hundreds of deputies, National Guard troops and coroners are sifting through leveled homes and mangled cars for human remains."They are going to be searching vehicles that have been burned. They'll be searching residences that have been burned. Checking around the residences ... our mission is to find the victims from this fire, recover them and get them identified and notify the families to give them some answers," Butte County Sheriff's Investigations Sgt. Steve Collins said.President Donald Trump is expected to visit the region Saturday as firefighters continue battling the blaze. 1578

As our country works to rebound, we're helping you manage the pressure as the pandemic is shifting caregiving responsibilities.More millennials are taking on this responsibility now. They're becoming a greater percentage of what's known as the "sandwich generation." Those are people who are caring for both their own kids and their aging parents.New numbers from insurance company New York Life show a third of millennials are doing this now.“We're not replacing the typical 49-year-old woman who's the family caregiver. She's still doing it, but the need is so great that more and more young people are called into the role as well and that's going to continue well after the COVID pandemic,” said John Schall, CEO of the Caregiver Action Network.Nearly half of the so-called "sandwich generation" expect to be a caregiver in some capacity for six or more years.The added financial strain is one concern. Schall says out of pocket expenses can be about a thousand dollars a month.More than half of these caregivers say they're spending more than usual per month to care for others as a result of the pandemic. That means they're contributing less to their savings and their retirement.There's also the concern about the mental toll.“With millennial generation caregivers, you may not be thinking about depression, you know, at that age, but the fact is the sheer stress of the role of being a family caregiver increases that risk of depression twice as often,” said Schall.If you are feeling overwhelmed, the caregiver help desk from the Caregiver Action Network can be one place to turn. You can call them free of charge at 855-227-3640. 1648