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The entire cast of the "Guardians of the Galaxy" films signed an open letter in support of James Gunn, the director of the series' first two films.Gunn was recently fired as the director of the upcoming third movie after it was revealed he made a number of offensive jokes on Twitter between 2008 and 2012.We are not here to defend his jokes of many years ago but rather to share our experience having spent many years together on that set making Guardians of the Galaxy 1 and 2. The character he has shown in the wake of his firing is consistent with the man he was every day on set, and his apology, now and from years ago when first addressing these remarks, we believe is from the heart, a heart we all know trust and love," the letter reads in part.The letter was signed by actors Dave Bautista, Bradley Cooper, Vin Diesel, Sean Gunn, Karen Gillan, Pom Klementieff, Karen Killan, Christ Pratt, Zoe Saldana and Michael Rooker.Read the letter in its entirety in the tweet below. 1005
The Centers for Disease Control and Prevention have changed its definition of a “close contact,” which impacts the agency’s recommendation on who should quarantine amid the coronavirus pandemic.Previously, the CDC recommended that those who were within 6 feet for 15 minutes of someone infected with the coronavirus should quarantine for two weeks. Now, the CDC recommends that those who are in contact with someone infected for 15 minutes over a 24-hour period should quarantine.The CDC offers the following recommendations for those who have been in contact with someone recently infected with the coronavirus:Stay away from others, especially people who are at higher risk for getting very sick from COVID-19, such as older adults and people with other medical conditions, if possible.If you have been around someone with COVID-19, stay home and away from others for 14 days (self-quarantine) after your last contact with that person and monitor your health.If you have a fever, cough or other symptoms of COVID-19, stay home and away from others (except to get medical care or testing, if recommended).If you need support or assistance while in self-quarantine, your health department or community organizations may be able to provide assistance. 1258

The first round of the NFL Draft got underway Thursday evening and Oklahoma quarterback Baker Mayfield was selected as the first overall draft pick by the Cleveland Browns. Mayfield will likely take over as Cleveland's starting quarterback in the fall after the Browns finished the 2017 season with a winless 0-16 record. Mayfield was a three-year starter at Oklahoma after starting one season for Texas Tech. He threw for 131 touchdowns over his four collegiate years, which is fourth all time in NCAA Division I history. According to most NFL Draft experts, five college quarterbacks will likely be selected in the first round on Thursday. The group includes USC's Sam Darnold, Oklahoma's Baker Mayfield, Wyoming's Josh Allen, UCLA's Josh Rosen and Louisville's Lamar Jackson. 807
The Food and Drug Administration released updated safety standards Tuesday for makers of COVID-19 vaccines despite efforts by the White House to block them, clearing the way for requirements that are widely expected to prevent the introduction of a vaccine before Election Day.In the new guidelines posted on its website, the FDA said vaccine makers should follow trial participants for at least two months to rule out any major side effects before seeking emergency approval. That standard had been a sticking point between the FDA and White House officials, who said it could unreasonably delay the availability of COVID-19 vaccines.President Donald Trump has repeatedly insisted a vaccine could be authorized before Nov. 3, even though top government scientists working on the effort have said that timeline is very unlikely. On Monday Trump said vaccines are coming “momentarily,” in a video recorded after he returned to the White House.Former FDA officials have warned that public perception that a vaccine was being rushed out for political reasons could derail efforts to vaccinate millions of Americans.A senior administration official confirmed Monday that the White House had blocked FDA’s plans to formally publish the safety guidelines based on the two-month data requirement, arguing there was “no clinical or medical reason” for it.But on Tuesday, the FDA posted the guidance on its website, making clear that regulators plan to impose the safety standards for any vaccine seeking an expedited path to market.FDA Commissioner Stephen Hahn said in a statement that he hoped the guidelines would help “the public understand our science-based decision-making process that assures vaccine quality, safety and efficacy.”The requirements are aimed at companies seeking rapid approval through the FDA’s emergency authorization pathway. That accelerated process, reserved for health emergencies, allows medical products onto the market based on a lower bar than traditional FDA approval. But FDA has made clear only vaccines that are shown to be safe and effective will be authorized for coronavirus.Former FDA acting commissioner Dr. Stephen Ostroff said the requirements seem reasonable given the agency is in largely “uncharted territory” in terms of considering emergency use of a vaccine. The agency has only previously cleared one vaccine through the method — a decades-old shot that was authorized to prevent anthrax poisoning in 2005.“There really is no margin for error here,” Ostroff said. “Even when you’re talking about limited use of a vaccine there has to be some level of assurance that there isn’t a risk here that would far outweigh the benefit.”Dr. Peter Marks, the head of FDA’s vaccine division, said Tuesday that the two-month follow-up requirement was chosen to be “something reasonably aggressive, but not too conservative — right in the middle.” He spoke at a symposium organized by Johns Hopkins University.Initial doses of vaccines for emergency use would likely be reserved for medical workers and people with health conditions that make them particularly vulnerable to coronavirus. Full FDA approval for the general population will require significantly more data and is not expected until mid-2021.The White House attempt to block the guidance followed a string of instances in which the Trump administration has undercut its own medical experts working to combat the pandemic. FDA’s Hahn has been attempting to shore up public confidence in the vaccine review process for weeks, vowing that career scientists, not politicians, will decide if the shots are safe and effective.Pfizer CEO Albert Bourla has stoked excitement by saying that he expects data on whether the company’s candidate works to be ready in late October. But a number of variables would still have to align for the company to submit, and the FDA to review and greenlight, a vaccine application before Nov. 3. Pfizer’s competitors Moderna, AstraZeneca and Johnson & Johnson are working on longer research timelines.Vaccine development typically takes years, but the U.S. government has invested billions in efforts to accelerate the process and help multiple drugmakers prepare multiple candidates. All the doses will be purchased by the federal government for use vaccinating the U.S. population.Beyond exposing the rift between the White House and FDA, the delay in releasing the guidelines may have had limited practical effect.FDA scientists have been discussing the guidelines publicly for weeks and have made clear that the recommendations have already been shared with each of the vaccine developers.Former FDA Commissioner Scott Gottlieb said Tuesday that drugmakers depend on the FDA’s science-based endorsement to vouch for the safety and effectiveness of their products.“I can’t imagine a circumstance where a sponsor would challenge or seek to undermine the FDA’s role here,” Gottlieb said at the COVID-19 symposium. “This is precisely the moment when we need an objective, neutral arbiter.”Last week, Gottlieb and six other former FDA commissioners blasted the Trump administration for “undermining the credibility” of the agency in a op-ed calling for the release of the then-stalled vaccine guidelines.“Scientists should make decisions based on data, unfettered by political pressure or the intrusions of ideology or vested interests,” the officials wrote.___AP Medical Writer Lauran Neergaard contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 5644
The Chico Mall has everything you'd expect to find there during the holiday season -- non-stop Christmas music, trees and oversized ornaments, along with signs advertising great deals for increasingly frenzied shoppers.It also has a temporary classroom space and a FEMA Disaster Recovery Center to help people who lost their homes in the Camp Fire, which devastated nearby Paradise, California, and the surrounding area.While they're at the mall to sign up for benefits or take care of other business, a lot of parents are bringing their kids to meet Santa Claus, said Jim Hoskins, the Chico Mall Santa.The Kentucky native, who said he'd prefer you call him Santa, has a gentle voice and a kind smile. He ended his interview with a quick "Ho, ho, ho" as he hung up the phone.He said you'd never know that many of the children he's met had lost their homes."Most of them are smiling," he said, though he does have to win over the occasional crier. "They are astounding."The kids' basic needs have been taken care off, thanks to FEMA and the generosity of the community, Hoskins said, so they're asking Santa for dirt bikes, iPhones, Paw Patrol toys and something called L.O.L Surprise dolls.But many of them do ask for something that Santa can't give -- a home."I usually say 'I can't do this in a year. I don't have the magic to do it right now, but we will get you one,'" he said. "I can't give them instant gratification on that, but I can give them some satisfaction that it will be done."He said some children have been concerned that Santa wouldn't be able to find them since their homes have burned down. He says they don't need to worry about that."I say 'I know your relatives and I've got GPS to track you with,'" he said. "It makes them feel better once their parents confirm it."Kylie Wrobel took her 7-year-old daughter, Ellie, to see Santa on Saturday.The first thing she asked for was toys for her dog, Daisy."She has the biggest heart," Wrobel said. "She was worried about our dog before herself, and then she asked for a Barbie mansion."Wrobel said she only grabbed her cell phone charger before leaving her Paradise rental house. She didn't have rental insurance, so they lost everything.Wrobel usually takes a picture of her daughter and Santa on her phone instead of buying one from the mall, she said, but this year's photo was really cute -- and it's the only hard copy photo they have now.They picked out a frame and put it out in the trailer where they're living, she said, along with their "Elf on a Shelf."Kathleen Mahnke said that Santa waved at her twin boys, who are about to turn two, as they they were walking through the mall to the FEMA center."As a mom, I can tell who is a kid lover," she said. "He was kind and fun, and patient with understanding that young kids take a while to warm up to strangers."She said she also appreciated the mall offering half off the photo packages for people who went through the fire.Hoskins says he's amazed by how resilient the children and their parents are when he meets them."I see more positive outlooks and attitudes than I do negative," he said. 3141
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