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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

SHANGHAI, Nov. 28 (Xinhua) -- The Shanghai municipal government Monday launched the microblog "Shanghai City" on China's popular Twitter-like microblogging service Weibo.com.The microblog, officially verified as originating from the Information Office of Shanghai Municipal Government (IOSMG), has accumulated more than 30,000 followers in the five hours since its launch.According to IOSMG, the content of the postings will be mainly about new policies and regulations, practical information related to activities in Shanghai, and interactions with Internet users over issues of public concern.Vegetable prices, the selection of affordable housing, and upcoming cultural activities in Shanghai are included in the first several postings.Some 600 government agencies and 300 government officials of various levels in Shanghai have verified Weibo accounts, the IOSMG said.The "Shanghai Metro," the official microblog of the city's metro operator with over 1.15 million followers, is considered one of most influential government microblogs in China.The latest statistics show that China now has more than 300 million registered microblog users. Related:Beijing city gov't opens press release microblogging platformBEIJING, Nov. 17 (Xinhua) -- The Beijing municipal government Thursday launched a news release platform on Sina's weibo.com, China's popular Twitter-like microblogging service.Twenty municipal government agencies will post newly-unveiled policies and regulations, work developments, and information of news conferences on the joint microblog account, said Wang Hui, head of the Beijing municipal government's information office.

SINGAPORE, Oct. 10 (Xinhua) -- A Singapore start-up firm has devised an innovative application to allow phone users to have access to their positioning information within buildings, where traditional global positioning system has often proved inaccurate, local daily Business Times reported on Monday.The firm YFind Positioning System feels that the application can help turn Singapore into the world's first location- intelligent city.Ting See Ho, co-founder of the firm, said the application works by first verifying the GPS coordinates to identify the building the user is in, and then collecting RSSI (received signal strength information) readings off WiFi access points within the building.The information is then sent by the phone to the central positioning server for comparison against records of the radio map of the building, which is calibrated earlier by the company.Ting said the RSSI readings continually fluctuates, making it difficult to estimate a position. This is where YFind Positioning System steps in with its patent-pending probabilistic algorithms to help accurately estimated the user's indoor positions.Once the phone application determines the location, then, it is able to map a course for a shop or other destination within the building where the user wants to go."You can think of it as creating an 'indoor GPS' environment in the buildings where satellite signals cannot be read," Ting said.He said that more than ten organizations in Singapore have approached the company to discuss deployment and partnerships and that it has begun work on three proof-of-concepts.The company's immediate goal is to make Singapore the world's first location-intelligent city before going to other cities, he said.

BEIJING, Dec. 17 (Xinhua) -- Senior Communist Party of China (CPC) official Zhou Yongkang has called for efforts to promote a police campaign aimed at better addressing public complaints.Zhou, a member of the Standing Committee of the Political Bureau of the CPC Central Committee, made the remarks in a written instruction on the campaign launched by the Ministry of Public Security on Friday.During the six-month campaign, police will be sent to more households to settle disputes and complaints or help solve public problems. The public will also be invited to supervise the work of the police, according to the ministry.Zhou said he believed the campaign would cement ties between the police and the masses and called on police to build a positive image for themselves during the initiative.The desirable "positive image" would only be possible by promptly addressing those most-attended security issues, said Meng Jianzhu, minister of public security, at Friday's launching ceremony.Meng urged his fellow police officers to make solid progress in enhancing the public's sense of security through this campaign.Police services on household registration, exit & entry, traffic and fire fighting were specifically mentioned by Meng, which were instructed to be strengthened or improved.

BEIJING, Dec. 31 (Xinhua) -- In a New Year's address broadcast on Saturday, Chinese President Hu Jintao vowed that China will continue to develop friendly exchanges with other countries and positively participate in international cooperation on global issues.While addressing domestic and overseas audiences via state TV and radio broadcasters, Hu urged the acceleration of the transformation of the country's economic development pattern and structural adjustments while making more efforts in ensuring people's livelihood.The country will continue to balance maintaining steady and relatively fast economic growth with adjusting its economic structures and managing inflation expectations, he said in the speech titled "Jointly Improve World Peace and Development," which was broadcast by China Radio International, China National Radio and China Central Television.A photo released on Dec. 31, 2011 shows Chinese President Hu Jintao delivering a New Year address, titled "Jointly Improve World Peace and Development", to domestic and overseas audiences via state TV and radio broadcasters.China will stick to the guidelines of "one country, two systems," "Hong Kong people governing Hong Kong," "Macao people governing Macao," and a high degree of autonomy in maintaining the long-term prosperity and stability of Hong Kong and Macao, Hu said."We will adhere to the principles of 'peaceful reunification' and 'one country, two systems,' continue to push forward the peaceful development of cross-Strait relations, ensure the basic benefits for those of the Chinese nationality, and endlessly work for the common benefit of the compatriots on both sides of the Taiwan Strait," he said.2011 was the first year of the country's 12th Five-Year Plan period (2011-2015). In the face of complicated international situations and arduous tasks in maintaining domestic reform, development and stability, Chinese people united and continued to push forward the opening up and reform drive and the socialist modernization construction, while maintaining steady and relatively fast economic growth and making progress in building a well-off society in an all-around way, he said.China was also actively engaged in international cooperation to boost the growth of the global economy and financial stability, and it was involved in resolving international and regional issues, he said.The world is currently witnessing multipolarization and globalization, and various countries are increasingly interdependent, Hu said."However, the instability and uncertainty of the world economic recovery is on the rise, international and regional hot-topic issues have cropped up one after another, and the peace and development of the world faces unprecedented opportunities and challenges," Hu said.China will stick to peace, development and cooperation, adhere to independent foreign policy, maintain world peace and promote common development, Hu said.The country will stick to the principle of mutual benefit when opening itself up, he said."We will develop friendly cooperations with all countries on the basis of the five principles of peaceful co-existence, and we will continue to actively participate in international cooperation on global issues," Hu said."I believe that as long as people from all countries make efforts hand-in-hand, the world will have a better future and the welfare of the people of all countries will improve," Hu said.An article by Hu on boosting the country's cultural development will be published in Qiu Shi (Seeking Truth), an official magazine of the Communist Party of China Central Committee, on Jan. 1.

来源：资阳报