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Researchers published what they say is the first case of a living person diagnosed with the degenerative brain disease chronic traumatic encephalopathy or CTE.While unnamed in the study, lead author Dr. Bennet Omalu confirmed to CNN that the subject of the case was former NFL player Fred McNeill -- who died in 2015.Omalu is credited with first discovering CTE in professional football players. Until now, the only way to diagnose the disease is with a brain exam after death.The diagnosis was first made using an experimental brain scan that can trace a signature protein of CTE called tau. The authors then confirmed the diagnosis with an autopsy. The case study was published in the journal Neurosurgery this week.'It looked like just depression'Omalu first presented these findings exclusively to CNN's chief medical correspondent, Dr. Sanjay Gupta, in 2016. McNeill's wife, Tia, and his two sons, Gavin and Fred Jr., told Gupta then that they saw Fred transform from a fun loving family man at the center of their lives into a man who was dealing with symptoms of memory loss, anger and depression that tore their family apart."There are some times where the father is the stronghold in the family, or the anchor. If you lose that, everything kind of falls apart. That's kind of what happened for us. It looked like financial issues at first; it looked like marital issues, and they separated; then it looked like just depression," Gavin told Gupta.CTE is known for plaguing people with Alzheimer's like symptoms such as memory loss, rage, mood swings, and in some cases, suicidal ideation.Severity of the disease is categorized into four stages, with stage 4 being the most severe. While researchers don't know exactly why certain people develop the disease and others don't, they believe that it results from repeated blows to the head that trigger a build up of tau proteins in the brain.CTE has been called football's "concussion crisis," however experts point out that CTE can develop from any repeated head injury. According to the Boston University CTE Center, "this trauma includes both concussions that cause symptoms and subconcussive hits to the head that cause no symptoms." These subconcussive hits can include the repeated trauma the brain experiences from constant plays, hitting the turf, and tackling. Wrestlers, boxers, and military troops have also been diagnosed with the disease.Seeing CTEWhile McNeill is the first case to be confirmed with an autopsy, the experimental technology has been used on at least a dozen other former NFL players, including Pro Football Hall of Famer, Dallas Cowboy Tony Dorsett. Omalu helped develop and is invested in the diagnostic exam, which uses a radioactive "tracer" called FDDNP to bind to tau proteins in the brain. The tau proteins can then be seen on a PET scan of the brain.Critics have said the protein also can highlight another protein called amyloid, which may be indicative of Alzheimer's or other forms of dementia. But Omalu noted that in CTE, tau makes distinctive patterns in the brain. It has a "specific topographic signature," he said, and that pattern can be detected in imaging.Omalu said he and his team are currently raising money to start a phase 3 clinical trial to further test the technology and replicate what they have seen in McNeill. He anticipates that once funds are raised, it will take another two to three years for the trial and then another year, at least, for approval from the US Food and Drug Administration. When asked, how soon a commercial test could be available, Omalu predicted it could be as soon as a few years. "We are looking at less than five years," he said.  3711

President Donald Trump's lead lawyer, John Dowd, has resigned from the President's personal legal team handling the response to the Russia investigation."I love the President and wish him well," Dowd said in a statement to CNN.Dowd's resignation comes as Trump has stepped up his attacks on special counsel Robert Mueller and days after Dowd said in a statement the investigation should end, initially claiming he was speaking for the President before saying he was only speaking for himself. 500

Rep. Duncan Hunter and his wife, Margaret, were indicted Tuesday on charges related to the misuse of 0,000 worth of campaign funds for personal expenses and the filing of false campaign finance records.The charges of wire fraud, falsifying records, campaign finance violations and conspiracy were the culmination of a Department of Justice investigation that has stretched for more than a year, during which the Republican congressman from California has maintained his innocence.Republican Party leaders had long worried that with a potential indictment looming, Hunter's traditionally safe district which makes up much of eastern San Diego County could be at risk of Democratic takeover in November's midterm election.Hundreds of thousands of dollars in unusual charges on Hunter's campaign credit card had come under scrutiny, including among other things, an Italian vacation, dental work, purchases at a surf shop, and huge tabs at bars in restaurants in the San Diego and Washington DC areas. Among the most mocked charges was airfare for a pet rabbit to fly with the family, which an aide said was mistakenly charged to the wrong credit card.Hunter, a former Marine, has reimbursed his campaign account some ,000 since the Federal Election Commission first questioned spending on video games in 2016, according to Federal Election Commission records."There was wrong campaign spending, but it was not done by me," Hunter told KGTV-10, a San Diego television station, earlier this year.His comments have cast blame on his wife and former campaign manager, Margaret Hunter, who also made charges on the campaign credit card.Hunter's lawyers said last year that "any mistakes were made they were strictly inadvertent and unintentional."California's 50th District is a staunchly Republican district with many current and former military families that covers much of eastern San Diego County. The Congressman's father, Duncan L. Hunter, represented parts of the district (which changed after redistricting) and has rallied donors and supporters to his son's side.Hunter's Democratic challenger, Ammar Campa-Najjar, a former department of labor aide in the Obama administration, has repeatedly outraised him.Many Hunter allies believe he will stay in his House seat while fighting the charges.Even if a federal candidate chooses to withdraw from contention, their name will remain on the ballot unless they seek removal of their name from a judge, according to the California Secretary of State's office.At this late juncture, there is no possibility of a write-in campaign. Only Hunter and Campa-Najjar will appear on the November ballot, since they were the top vote-getters in California's top-two primary in June.This is a breaking news story and will be updated.   2789

Reporters are pressing McConnell to discuss the presidential election/the President’s allegations, but McConnell keeps saying he has already said what he wanted to say. I asked: if Joe Biden wins, will there be a peaceful transfer of power? He did answer that one. @LEX18News pic.twitter.com/DQ3KTyHeq0— Karolina Buczek (@Karolina_Buczek) November 6, 2020 363

Republican Senate Majority Leader Mitch McConnell has won a seventh term in Kentucky.The 78-year-old McConnell defeated Democrat Amy McGrath, a retired Marine combat pilot who challenged him as a political outsider. McConnell is the longest-serving Republican leader in Senate history.As President Donald Trump’s top ally on Capitol Hill, McConnell led efforts to defend the president during his impeachment acquittal in the Senate. He also worked with Trump on a tax overhaul and orchestrated Senate confirmation of more than 200 judicial appointments, including Amy Coney Barrett to the Supreme Court.McGrath also lost a race for a House seat in 2018. 661

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