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As questions arise over when a coronavirus vaccine should be granted FDA approval, the leaders of several major pharmaceutical companies announced they have signed a pledge not to rush the development of a vaccine.The companies, AstraZeneca, BioNTech, GlaxoSmithKline, Johnson, Merck, Moderna, Novavax, Pfizer and Sanofi, released a joint statement on Tuesday confirming the pledge.The pledge includes the following points:Always make the safety and well-being of vaccinated individuals our top priority.Continue to adhere to high scientific and ethical standards regarding the conduct of clinical trials and the rigor of manufacturing processes.Only submit for approval or emergency use authorization after demonstrating safety and efficacy through a Phase 3 clinical study that is designed and conducted to meet requirements of expert regulatory authorities such as FDA.Work to ensure a sufficient supply and range of vaccine options, including those suitable for global access.There has been pressure on both the FDA and manufactures to develop and approve a vaccine for the coronavirus. There have been more than 190,000 coronavirus-related deaths in the US since March, and the economic impact of the virus has cost millions of jobs.While most developed countries have not had the same public health pain as the US, the economic impact of the virus has been felt worldwide. The International Monetary Fund estimates a nearly 5% loss in global GDP in 2020.In Russia, the country claimed to begin distributing a coronavirus vaccine despite US-based vaccine candidates likely being months away from being able to demonstrate efficacy.The pressure domestically has also ratcheted up as President Donald Trump has suggested a vaccine could be ready by this fall’s presidential election."We're going to have a vaccine very soon... maybe even before a very special date, you know what date I'm talking about,” Trump said on Monday.In late August, the CDC told states to begin to prepare distributing a vaccine by Nov. 1. But Surgeon General Jerome Adams said that just because states will be ready to help distribute a vaccine on Nov. 1 does not mean a vaccine will be ready by then."We've always said that we're hopeful for a vaccine by the end of this year or the beginning of next year,” Adams told Good Morning America."We want to make sure states are available to distribute it," he added.The companies signing on the pledge said that the FDA has strict protocols for vaccine candidates. A typical vaccine trial takes one to three years, but the companies believe only a safe and effective vaccine will be granted approval.“FDA has established clear guidance for the development of COVID-19 vaccines and clear criteria for their potential authorization or approval in the US,” the companies wrote in the pledge. “FDA’s guidance and criteria are based on the scientific and medical principles necessary to clearly demonstrate the safety and efficacy of potential COVID-19 vaccines. More specifically, the agency requires that scientific evidence for regulatory approval must come from large, high quality clinical trials that are randomized and observer-blinded, with an expectation of appropriately designed studies with significant numbers of participants across diverse populations.” 3296

At least 10 people have died after flash flooding hit the Aude region of southern France, local officials said Monday.Roads were cut off and cars overturned after three months' worth of rain fell in six hours overnight Sunday into Monday, causing rivers to flood.An 88-year-old nun was killed after water swept through a nunnery in Villardonnel, while four people died overnight in nearby Villegailhenc.The death toll was lowered by the Ministry of the Interior, after initially being placed at 13. Another person is missing and five are seriously injured, officials said.Seven hundred firemen and seven helicopters have been mobilized in response to the flooding, which has reached unprecedented levels in the Aude valley, according to France's flooding watchdog, Vigicrues. 783

BAKERSFIELD, Calif. (AP) — The California Highway Patrol says an officer conducting a routine traffic stop found ,000 of stolen Disney merchandise.The CHP says a Nissan Sentra was pulled over Friday in Kern County after the driver failed to stop when approaching a school bus.The officer learned the driver's license was suspended and then discovered hundreds of pins and other merchandise allegedly stolen from Disneyland.Officials didn't immediately identify the motorist.Authorities say the CHP has contacted Disneyland security and made arrangements to return the property. 588

Ashland University in Ohio is offering a new ,000 scholarship to talented Fortnite players."Fortnite Battle Royale" will be offered in fall 2018 as part of the university's esports program.The AU esports team will be the first known program in the country to add the game to its official offerings. Head Coach Josh Buchanan is excited to add the popular game to the college's gaming titles."Fortnite appeals to both the core and casual gaming audience," said Buchanan in a news release. "We're excited to provide this platform for gamers who want to showcase their skills in a more competitive space."The team at Ashland will arrange four-player teams that practice regularly and compete together.Scholarships will be awarded to players based on skill level and academic requirements.The university plans to conduct open tryouts for Fortnite players next school year. Ashland already offers League of Legends, Overwatch, Counter-Strike: Global Offensive and Rocket League in their esports program. The coach hopes eventually other schools will for programs to set up collegiate leagues for the team to compete against.  1184

As the clock winds down on the midterms, there are scattered reports of people across the country still having trouble voting. In some places, judges are being asked to extend voting times to make up for trouble earlier in the day.Here are some of the voter issues and irregularities that CNN has found so far this Election Day, from power outages to excessive humidity. 378

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