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WASHINGTON, April 3 (Xinhua) -- Scientists have confirmed that metabolic syndrome, a constellation of conditions that increases the risk of heart disease and diabetes, may also increase the risk of the two most common types of liver cancer, according to data presented at the American Association for Cancer Research's 102nd Annual Meeting 2011, held in Orlando, Florida on April 2-6.Katherine McGlynn, a senior investigator at the National Cancer Institute, said approximately one-third of the U.S. population has metabolic syndrome, which is defined as the co-occurrence of at least three of the following five conditions: raised blood pressure, elevated waist circumference, low HDL or "good" cholesterol, raised triglyceride levels and raised fasting plasma glucose levels.According to McGlynn, persons with these conditions may be at increased risk of developing hepatocellular carcinoma and intrahepatic cholangiocarcinoma.For the current study, researchers identified 3,649 cases of hepatocellular carcinoma and 743 cases of intrahepatic cholangiocarcinoma. They compared the medical history of these patients with the medical histories of 195,953 cancer-free adults.Statistical analyses showed that the persons with liver cancer were significantly more likely than cancer-free persons to have a prior history of metabolic syndrome: 37.1 percent of patients with hepatocellular carcinoma had pre-existing metabolic syndrome, as did 29.7 percent of patients with intrahepatic carcinoma; only 17.1 percent of the cancer-free adults had metabolic syndrome.Liver cancer incidence has been rising since the 1980s in the United States. The factors related to the increase are not well understood. "A lot of attention has focused on viral risk factors, but a significant part of the increase may be due to metabolic syndrome, as well as to diabetes and obesity," said McGlynn."The prognosis for liver cancer is only marginally better than the prognosis for pancreatic cancer, with a five-year survival of approximately 10 percent," she said. "Prognosis is more favorable, however, when liver cancers are diagnosed at early stages when they are small and localized to the liver."

XI'AN, Feb. 21 (Xinhua) -- Nearly 100 children were sickened by food poisoning Monday noon at a kindergarten in northwest China's Shaanxi Province.The accident occurred at Zhaocun Beibeile Kindergarten at Weiyang District of the provincial capital Xi'an City, where the children suffered from nausea and diarrhea after lunch, said a spokesman from the Weiyang District Government.The sickened children were rushed to five local hospitals for treatment, and their conditions were reported as not life threatening, the spokesman said.An initial inspection showed that their sickness was caused by nitrite intoxication, and the exact cause is under investigation.

LOS ANGELES, May 15 (Xinhua) -- Using a simple, minimally- invasive technique to analyze cells from the interior of the nose, U.S. researchers have detected lung cancer in its earliest stage.For the study, the researchers at the Boston University Medical Center collected nasal epithelial cells from thirty three smokers who were undergoing medically-indicated bronchoscopies for suspicion of lung cancer, according to the American Association for the Advancement of Science (AAAS) on Sunday.Of these patients, 11 were found to have benign disease and 22 had lung cancer. Brushings were taken from the right or left nostril and profiled on microarrays, a process that allows researchers to study gene expression changes.The researchers identified 170 genes that were differentially expressed between patients with and without lung cancer. They also found that genes linked to colon cancer and adenocarcinoma, as well as genes that trigger cell division and blood vessel growth, were expressed more heavily in patients with cancer. Genes involved in tumor suppression were also expressed at lower levels in these patients.Earlier studies have used gene expression differences in the bronchial airways to identify lung cancer in its early stages. The researchers relied on those results to design the current study."In this study we used the same principle as we used in our earlier studies of bronchial tissue, only this time, those methods were used to study nasal cells," said study author Christina Anderlind, MD, Instructor of Medicine. "Our hypothesis was that the upper airway epithelium of smokers with lung cancer displays a cancer-specific gene expression pattern, and that this airway nasal gene expression signature reflects the changes that occur in lung tissue."

WASHINGTON, May 2 (Xinhua) -- Rice originated in China, a team of U.S. genome researchers has concluded in a study tracing back thousands of years of evolutionary history through large-scale gene re-sequencing.Their findings, which appear Monday in the latest issue of the Proceedings of the National Academy of Sciences (PNAS), indicate that domesticated rice may have first appeared as far back as approximately 9,000 years ago in the Yangtze Valley of China. Previous research suggested domesticated rice may have two points of origin -- India as well as China.Asian rice, Oryza sativa, is one of world's oldest crop species. It is also a very diverse crop, with tens of thousands of varieties known throughout the world. Two major subspecies of rice -- japonica and indica -- represent most of the world's varieties. Sushi rice, for example, is a type of japonica, while most of the long-grain rice in risottos are indica.Because rice is so diverse, its origins have been the subject of scientific debate. One theory -- a single-origin model -- suggests that indica and japonica were domesticated once from the wild rice O. rufipogon.Another -- a multiple-origin model -- proposes that these two major rice types were domesticated separately and in different parts of Asia. The multiple-origin model has gained currency in recent years as biologists have observed significant genetic differences between indica and japonica, and several studies examining the evolutionary relationships among rice varieties supported more than domestication in both India and China.In the PNAS study, the researchers re-assessed the evolutionary history, or phylogeny, of domesticated rice using previously published datasets, some of which have been used to argue that indica and japonica rice have separate origins. Using more modern computer algorithms, however, the researchers concluded these two species have the same origin because they have a closer genetic relationship to each other than to any wild rice species found in either India or China.In addition, the study's authors examined the phylogeny of domesticated rice by re-sequencing 630 gene fragments on selected chromosomes from a diverse set of wild and domesticated rice varieties. Using new modeling techniques, which had previously been used to look at genomic data in human evolution, their results showed that the gene sequence data was more consistent with a single origin of rice.In the study, the investigators also used a "molecular clock" of rice genes to see when rice evolved. Depending on how the researchers calibrated their clock, they pinpointed the origin of rice at possibly 8,200 years ago, while japonica and indica split apart from each other about 3,900 years ago. The study's authors pointed out that these molecular dates were consistent with archaeological studies.Archaeologists have uncovered evidence in the last decade for rice domestication in the Yangtze Valley beginning approximately 8, 000 to 9,000 years ago while domestication of rice in the India's Ganges region was around about 4,000 years ago."As rice was brought in from China to India by traders and migrant farmers, it likely hybridized extensively with local wild rice," explained New York University biologist Michael Purugganan, one of the study's co-authors. "So domesticated rice that we may have once thought originated in India actually has its beginnings in China."

BEIJING, May 19 (Xinhuanet) -- LinkedIn said Wednesday that its stock will debut at 45 U.S. dollars per share, a higher price than the company was expecting even earlier this week, media reports said.The first major U.S. social networking firm to go public, LinkedIn jacked up its initial public offering (IPO) share price for 7.84 million shares to 45 dollars just a week after it first set a target of 32-35 dollars per share.It minted LinkedIn with a market value of more than 4 billion dollars, the highest for a U.S. Internet company taking its first bow on Wall Street since Google Inc. went public nearly seven years ago.The sale could bring in more than 354 million dollars. The company's shares are expected to begin trading on the New York Stock Exchange on Thursday under the symbol "LNKD".LinkedIn has more than 100 million members in over 200 countries and territories. In 2010, the company made 15 million dollars in profit on 243 million dollars in revenue, according to its SEC filing.LinkedIn's biggest shareholder is its founder and chairman, Reid Hoffman, who owns more than 21 percent of the company.