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LOS ANGELES, May 29 (Xinhua) -- Nineteen percent of
WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.

LOS ANGELES, April 2 (Xinhua) -- The United States could soon be faced with an epidemic of Non-Alcoholic Fatty Liver Disease ( NAFLD), one of the major contributing factors of chronic liver disease (CLD), the American Association for the Advancement of Science (AAAS) reported Saturday.If the current rates of obesity and diabetes continue for another two decades, the prevalence of NAFLD in the U.S. is expected to increase by 50 percent in 2030, AAAS said.The prediction is based on pre-existing clinical survey data over a 10 year period (1988-1994, 1999-2004 and 2005-2008), which included 39,500 adults from three survey cycles, according to the AAAS.Over the three cycles, the prevalence of NAFLD doubled from 5. 51 percent to 11 percent respectively. Furthermore, during the first survey cycle (1988-1994) 46.8 percent of all CLD's was related to NAFLD but by 2005-2008 this had increased to 75.1 percent. In addition, the prevalence of obesity and diabetes, the two key risk factors for NAFLD also steadily increased."If the obesity epidemic is anything to go by, the U.S. NAFLD epidemic may have a ripple effect worldwide," said Mark Thursz, Vice Secretary of the European Association for the Study of the Liver. "It is imperative that health systems continue to drive effective educational programs to reinforce awareness among the general public to alert them of the risks of obesity and promote the importance of diet and exercise."Non-alcoholic fatty liver disease is fast becoming one of the top concerns for clinicians due to the obesity epidemic and it's potential to progress to advanced liver disease which significantly impacts on overall liver-related mortality, Thursz said in remarks published by AAAS' website EurekAlert.org.NAFLD, considered as one of the major causes of morbidity and mortality worldwide, is the term used to describe fat build-up in liver cells in people who do not drink alcohol excessively. The disease is the most common persistent liver disorder in Western countries with an estimated overall prevalence of 20-30 percent, according to AAAS.NAFLD encompasses a spectrum of liver disease associated with insulin resistance, diabetes and obesity and as such people most at risk of NAFLD are those who are obese, have insulin resistance associated with diabetes, high blood pressure and cholesterol.
BEIJING, May 5 (Xinhua) -- A Chinese official has vowed to take every possible measure to ensure food safety in the country, saying the government has decided to launch national overhauls this year on sectors including milk products, cooking oil, health foods, meat and alcohol.Zhang Yong, director of the executive office of the food safety commission under the State Council, or Cabinet, said in an interview with Xinhua that the food and drinks in these five sectors are consumed in enormous quantities each day and they will do great harm and have an extensive social impact if a problem arises.Through special campaigns to overhaul these five sectors and by solving the most prominent problems, the government aims to accumulate experiences and create administrative systems in a bid to prevent food safety incidents and raise the overall level of food safety, Zhang said.The central government initiated a prolonged and stringent fight against the illegal use of additives in food last month, detailing measures to intensify supervision, upgrade safety limits, and increase penalties for violators.Vice Premier Li Keqiang warned of the great harm from illegal additives in food at a high-profile national meeting last month, promising a "firm attitude, iron-hand measures and more efforts" in dealing with the problem.Zhang Yong admitted "China is in a period when food safety incidents are likely to arise" since the country's food industry is on a fast track for development and a large number of food producers and catering operators are running their businesses in a small-scale or scattered way."It makes it more difficult for the government departments to conduct supervision on food quality and safety," Zhang said."We will take every possible measure to consolidate the feeble foundation to ensure food safety and curb food safety incidents as soon as possible," he said.According to Zhang, the government will also make efforts to improve supervision and emergency handling capabilities, raise the credibility and personnel quality of the involved enterprises, and severely punish violators.The Chinese government made the moves after a series of food safety scandals emerged despite the authorities' efforts to revamp the country's food industry. They included steamed buns dyed with unidentified chemicals, the use of "lean meat powder", also known as clenbuterol, a kind of fat-burning drug, as well as the use of illegal cooking oil known as "gutter oil."
MOSCOW, Feb. 9 (Xinhua) -- China's steady economic rise causes both high hopes and anxiety among world leaders, but a Russian expert believes China's peaceful development is an opportunity for the entire world.Yakov Berger of the Far East Institute of the Russian Academy of Sciences told Xinhua that China's policy of peaceful development is a strategic choice, aimed at long-term and sustainable growth."China overcame the global financial crisis, decreased poverty, and increased people's wealth," Berger said."Still, many important tasks for China remain to be fulfilled and first of all, modernization, industrialization and urbanization. This is why China needs strong and long-lasting peace," he said.Berger said China's policy of peaceful development has already won support from the majority of countries, so they are willing to cooperate with the world's most powerful developing nation."China's peaceful development gives chance to all people in the world, as China became the main engine of the global economic development. Many developed countries are gravitated to China because they depend on Chinese supplies and the Chinese market," Berger said.However, although some countries are aware that China's sustainable growth requires peace and stability, some eye China's growing influence as negative, the professor said.Berger said that Beijing tries to persuade Washington that China's rise does not threaten American security. The question, then, is to what degree is the U.S. ready to accept the new reality, Berger said.Berger cited two main reasons why some Western politicians don't trust Beijing."First, this is a natural response from the people who got used to a certain world order," he said, "Such an order implies the existence of the so-called 'golden billion' people who have access to all of civilization's benefits while the other five billion can't make ends meet."Berger said that when China attempts to achieve the same living standards, that induces some fears based on the notion that the Earth resources are limited.Berger believed the second reason is xenophobia and racism, which generates talk about the "Chinese threat.""But they talked about the 'China threat' even in times when China used to be an underdeveloped nation," Berger noted.
来源:资阳报