濮阳东方医院治早泄收费很低(濮阳东方妇科医院评价非常好) (今日更新中)

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — Days after pleading guilty to misusing campaign funds, Congressman Duncan Hunter has announced he will resign from Congress.Hunter, who represented the 50th District, pleaded guilty Tuesday to a federal charge of conspiracy to misuse campaign funds for personal use. Though after the plea, it wasn't clear if the embattled Congressman would resign.“Shortly after the Holidays I will resign from Congress. It has been an honor to serve the people of California’s 50th District, and I greatly appreciate the trust they have put in me over these last 11 years," Rep. Hunter said in a statement Friday.RELATED: Rep. Duncan Hunter pleads guilty to conspiracy to misuse campaign fundsHunter faces a possible five-year prison sentence and a 0,000 fine when he is sentenced March 17.Friday was the last day for Hunter to resign in time to force a special election. The timing of his decision now leaves the door open for Gov. Gavin Newsom to leave the seat vacant until after the 2020 election. Newsom can also still choose to proceed with a special election or consolidate the special election with a regularly scheduled election, such as the March 2020 Primary.Under California law, Newsom has 14 calendar days after a vacancy occurs to call for a special election, which must then be held within 140 days. Per Hunter's statement, a specific date of resignation wasn't given.RELATED: Who could take of the 50th District after Hunter's guilty pleaNewsom told 10News that California has already had two special elections in the past two weeks, but that they would try to "avoid redundancy.""We’d make that determination and the law is pretty prescriptive in terms of making a determination in a very prescribed period of time," Gov. Newsom said Wednesday. "Obviously the one focal point always is to avoid redundancy, to avoid waste as it relates to a cost to taxpayers and fatigue of having election after election. Our goal is to always line them up with existing elections to the extent legally possible."The San Diego County Registrar's Office tells 10News the longer Hunter waits, the more complex it could make the March election process.The Congressman said earlier this week he had decided to take a plea deal for the sake of his family. Hunter's wife and former campaign treasurer, Margaret, has already admitted to her role in the finance scandal and faces five years in federal custody and a fine of up to 0,000. She is set to be sentenced in April.RELATED: Reaction to Rep. Duncan Hunter's plea changeProsecutors alleged Hunter and his wife went on expensive family trips and made several other improper purchases over the course of six years. Supposed campaign-related events were planned around the family outings to justify using the funds. He and his wife were facing criminal charges including wire fraud, conspiracy and falsification of records ahead of a Jan. 22 court date.Before changing his plea, Hunter continued to maintain his innocence and accused the U.S. Attorney's Office of making a politically motivated case against him, saying two prosecutors were supporters of then-Democratic presidential frontrunner Hillary Clinton.Hunter had planned to seek another term in the November 2020 election. He was re-elected last November with 51.7 percent of the vote despite being indicted in the case just three months prior.Hunter, a Republican from Alpine, was first elected in 2008. He succeeded his father, Duncan Hunter Sr., who had held the seat for 28 years.RELATED COVERAGE:-- Hunter supports Gallagher, Trump amid Navy review controversy-- Hunter continues to fight one year after indictment-- TIMELINE: Campaign spending probe against HunterCurrently, three Republicans — former city council member Carl DeMaio, former member of Congress Darrell Issa, and State Senator Brian Jones — and Democrat Ammar Campa-Najjar are vying to be the district's next representative.After Hunter's announcement, DeMaio blasted the Congressman and called the timing of his decision "an intentional effort to manipulate the election timetable."“By intentionally delaying his resignation past the deadline for the calling of a Special Election, Congressman Duncan Hunter is silencing the voice of the voters of the 50th District for a full year in Congress. The voters of the 50th District deserve having their voice back in Congress as soon as possible and only a Special Election can give the voters a voice again," DeMaio said in a statement. "I urge Congressman Hunter to reconsider the timing of his resignation to provide a better and more expeditious transition of his office.”Campa-Najjar only said that his campaign was ready for the "early phases of this election."“Our campaign is full speed ahead and ready to take our working class, commonsense, country over party message to Congress. I actually live in this district — so as the only leading candidate who can actually vote in this race, I’m confident that we will outperform in the early phases of this election and go on to win the general election. I’ll stack my lived working-class experience against the other coastal elitist, millionaire candidates any day," Campa-Najjar's statement read.RELATED COVERAGE:-- Motion: Hunter spent campaign funds on "desire for intimacy"-- Hunter's wife pleads guilty in federal case 5321

SAN DIEGO (KGTV) - County health officials are encouraging local women to get vaccinated for "whooping cough" amid a possible epidemic.The county says pertussis, commonly known as "whooping cough," could turn into a possible local epidemic based on historical patterns."It’s critical for pregnant women and people who come into close contact with young infants to get vaccinated," Wilma Wooten, County public health officer, said. "Newborns are very susceptible to whooping cough because they are too young to be fully vaccinated. It is vital for pregnant women to be vaccinated in the third trimester to give protection to their unborn infants."So far in 2018, there have been 56 confirmed cases of pertussis.RELATED: This app says it can help you stay flu-freeLast year, San Diego County recorded at least 1,154 cases, the highest of any county in California. Wooten said the high numbers were partially attributed to reporting methods."Pertussis activity in our region appears to higher than the rest of the state, but much of this is due to the excellent detection and reporting of this potentially deadly disease by San Diego pediatricians and family physicians," Wooten said.Pertussis is a cyclical disease that peaks every three to five years, according to health officials. San Diego's last epidemics were in 2010 and 2014, with 1,179 and 2,072, respectively.RELATED: 20 more people died from the flu in San DiegoThe county said on in five of the San Diego County cases in 2017 were in individuals under three years of age, and 52 percent were between the ages of 10 and 17.The Centers for Disease Control and Prevention recommend a vaccination schedule to combat whooping cough: 1715

SAN DIEGO (KGTV) - As winter approaches, doctors are worried about more than the novel coronavirus."When winter comes we all tend to go indoors, and [viruses are] more likely to spread between us in school, in workplaces it's just going to happen," Dr. Davey Smith, Chief of Infectious Diseases at UC San Diego, said.If you develop a cough, fever, chills and you're achy, Dr. Smith said it could be a variety of viruses."We are going to have multiple viruses running around in the community at the same time. Double triple, it's not just the flu it's RSV that kids oftentimes get, adenoviruses and other seasonal viruses and they all look the same," he said.Dr. Smith is urging San Diegans to get a flu shot, especially this year, concerned about the hospital being overrun, "it's not just the PPE, it's the hospital beds, the doctors and the nurses, and everybody who has to take care of them."Cajon Valley Union School District has had students on campus since July. Poway is bringing students back on campus as part of a phased reopening plan.Vista Unified School District plans to reopen Tuesday.According to the Bureau of Labor Statistics, one million Americans returned to work in September.That combined with local COVID-19 cases rising, we could be in for a rough Fall and Winter.Dr. Davey said vigilance is key, "that means masks, washing our hands, staying at a safe distance, and if we can't do that then we're going to have problems in San Diego." 1467

SAN DIEGO (KGTV) - Black Friday is the official kick off to the holiday shopping season and with more shoppers purchasing packages, more thieves are looking to make a grab.San Diego Sheriff's deputies issued tips on Black Friday for consumers hoping to keep their new gifts safe this season.First, they advise that shoppers avoid leaving anything a thief would want visible in cars. That includes:PurseWalletMailPresentsBagsPackagesElectronics (i.e. iPad, iPhone, tablet, laptop, music player)A thief could get an address from shoppers via their car — using a driver's license, insurance registration card, or mail — and in turn try and burglarize a home for those recently-bought presents."The biggest mistake is them being on their phones, and not slowing down, taking the time to lock your cars, roll up your windows. Please make sure that any packages that you buy, you remove from your back seat, put them in the trunk, lock them, secure them," Sergeant Pamela Murphy said.She also wants shoppers to be mindful when they leave the store, especially at night, "don't have too many things in your arms that you can't carry or defend yourself."RELATED: San Diegans brave the pouring rain to score Black Friday dealsIf someone becomes a victim of a crime, deputies don't recommend posting about it on social media. Instead, call local law enforcement. The department does not monitor social media for potential crimes.Reporting a crime helps law enforcement track trends, which makes a difference in communities. "If there's trends we need to go out and make sure there's extra patrol and make sure our deputies are checking the area more often as well as the senior volunteers," Murphy said.RELATED: Black Friday strategies that actually workDuring the holidays the department has more frequent patrols, and puts up Sky Towers in mall parking lots, giving deputies an edge while surveying parking lots. 1913

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