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WASHINGTON — U.S. health officials have started two new studies to test various blood thinners to try to prevent strokes, heart attacks, blood clots and other complications in COVID-19 patients.Doctors increasingly are finding blood clots throughout the bodies of many people who died from COVID-19 along with signs of damage they do to kidneys, lungs, blood vessels, the heart and other organs.National Heart, Lung and Blood Institute Director Gary Gibbons says that hospitals have been giving seriously ill patients anti-clotting drugs to try to prevent this, but “quite frankly, we didn’t know how best to treat it” in terms of which drugs or doses to use and at what stage of illness.The National Institutes of Health will coordinate a study in hospitalized patients comparing low and regular doses of the blood thinner heparin. The study will involve more than 100 sites around the world participating in a research effort with various governments, drug companies, universities and others to speed coronavirus therapies.A second study in COVID-19 patients not sick enough to need hospitalization will test various strategies against placebo pills: baby aspirin or low or regular doses of the anti-clotting drug apixaban, sold as Eliquis in the United States. The goal there is preventing blood clots or hospitalization.A third study starting later will test blood thinners for people who have recovered and no longer test positive for the coronavirus. Evidence is building that they may remain at higher risk for blood clots. 1538

VISTA (CNS) - A man who allegedly stabbed a transient at the culmination of an Escondido crime spree pleaded not guilty to attempted murder and other charges Tuesday, with police saying new jail booking criteria established during the COVID-19 pandemic kept the suspect out of custody despite numerous arrests.Timothy Alvarado, 22, of La Mesa, is accused of stabbing the victim in the neck on May 16, following several other arrests in the weeks leading up to the alleged attack.Alvarado was arrested and released four times between May 2 and May 14 for allegedly stealing cars, including the same vehicle twice in four days from the same apartment complex, according to Escondido police.Alvarado faces an attempted murder charge in the May 16 stabbing, and about a dozen additional felony counts related to the car thefts. He faces 11 years to life in prison if convicted of attempted murder and a maximum of eight years and eight months behind bars for the vehicle thefts, according to the District Attorney's Office.Escondido police say new booking regulations instituted by the state to reduce jail populations prohibited them from booking Alvarado until he allegedly commited the stabbing, as his previous alleged crimes fell under the state court order lowering bail to Volunteers from Wasdale mountain rescue team carry 121lb (55kg) St Bernard dog, Daisy from England's highest peak, Scafell Pike, Sunday July 26, 2020. The mountain rescue team spent nearly five hours rescuing St Bernard dog Daisy, who had collapsed displaying signs of pain in her rear legs and was refusing to move, while descending Scafell Pike. The Wasdale Mountain Rescue team rely on public contributions to their JustGiving.com/wasdalemrt page to fund their mountain safety efforts. (Wasdale Mountain Rescue via AP) 529 for misdemeanors and nonviolent felonies.Alvarado's alleged May crime spree began about three weeks after he was released from jail after serving a burglary sentence.-- On May 2, Alvarado was allegedly spotted driving a minivan stolen from an Escondido used car lot, then fled from officers in a pursuit. He was arrested on suspicion of auto theft, possession of a stolen vehicle, felony evading, driving on the wrong side of the road during a pursuit, and resisting arrest. Police say he was cited and released.-- On May 4, Alvarado was arrested on suspicion of auto theft and possession of a stolen vehicle for allegedly stealing a Jaguar sedan from a local Motel 6. He was cited and released.-- On May 10, Alvarado was arrested on suspicion of auto theft, possession of a stolen vehicle and possession of a controlled substance for allegedly stealing a Mitsubishi Lancer and possessing methamphetamine. Police say he was cited and released.-- On May 14, Alvarado was arrested on suspicion of auto theft and possession of a stolen vehicle for allegedly stealing the same Mitsubishi Lancer, then cited and released. Both times the car was taken from the same Lincoln Avenue apartment complex, according to police.Alvarado was also contacted by officers two other times during that span, for an alleged municipal code violation on May 12 and resisting arrest and possession of drug paraphernalia on May 15. He was cited, but was not arrested either time, as neither offense would have had him booked even before the emergency bail schedules, police said.Police said the May 16 stabbing happened just before 3 p.m. A nearby Escondido police supervisor heard someone yelling "stop!" near the Escondido Sprinter Station at 796 W. Valley Parkway and saw a man emerge from bushes near the station and run west from the scene toward Tulip street. The victim then came out of the bushes holding his neck, and "was bleeding profusely," police said.Alvarado was detained by other officers on the bike path just west of Tulip Street.The victim was taken to Palomar Medical Center, where he underwent emergency surgery.Alvarado is being held without bail and is due back in court June 26 for a readiness conference. 3491

WASHINGTON — The government’s cybersecurity agency is expressing increased alarm about a hack of computer systems in the U.S. and around the globe that officials suspect was carried out by Russia.The cybersecurity unit of the Department of Homeland Security says the hack “poses a grave risk” to the U.S. government and state and local governments as well as critical infrastructure and private business.The Cybersecurity and Infrastructure Security Agency announced the SolarWinds Orion vulnerability that was disclosed this week as the compromised piece of software, was not the only way that hackers were able to get into government agencies, private companies and critical infrastructures over the last several months."CISA has determined that this threat poses a grave risk to the Federal Government and state, local, tribal, and territorial governments as well as critical infrastructure entities and other private sector organizations," the alert issued by the agency said. "CISA expects that removing this threat actor from compromised environments will be highly complex and challenging for organizations."The U.S. Energy Department is the latest government unit to announce they had systems compromised in the hack.The department says the impact of the hack appears to be “isolated to business networks” and "has not impacted the mission essential national security functions of the Department, including the National Nuclear Security Administration (NNSA)," which manages the country’s stockpile of nuclear weapons.It’s not just government agencies, Microsoft is reporting in a blog post more than 40 customers around the world appear to have been targeted in the hack.The hack creates a fresh foreign policy problem for President Donald Trump in his final days in office.President Trump has not made public comments regarding the hack, or the government’s response to Russia or whoever may be responsible. A White House senior official told CNN Trump was briefed on the hack by his top intelligence officials on Thursday.President-elect Joe Biden has also received briefings on the hack and released a statement."Our adversaries should know that, as President, I will not stand idly by in the face of cyber assaults on our nation," Biden said, making no specific mention of Trump or his administration, but also not naming Russia as the culprit.President-elect Joe Biden says his new administration “will make dealing with this breach a top priority from the moment we take office.” 2502

VISTA, Calif. (KGTV) - A man was sentenced to 10 years in prison Thursday for sexually assaulting a 15-year-old girl while she rode in an ambulance. The California Highway Patrol launched an investigation into the Feb. 21, 2017 incident involving 34-year-old David Carpio, a private ambulance company employee. The girl was being transported to Tri-City Medical Center in Oceanside when Carpio assaulted her and asked for her Snapchat information to start a relationship with her, investigators said. A CHP investigator posing as the girl communicated with Carpio through social media and text messages over several months, during which time officials gained damaging information. Other alleged female victims also came forward with claims against Carpio, saying he had sexually assaulted them when he was their neighbor. One of the women was 16 years old at the time of the encounter. Carpio pleaded guilty to sexual assault charges and was sentenced Thursday for sexual penetration of a minor and sexual battery. 1022

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