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Amesh Adalja, an infectious-disease expert at the Johns Hopkins Center for Health Security, agreed.

Amazon’s digital assistant Alexa was a central focus last year as well. In September, Amazon introduced a next-generation Echo powered by Alexa, as well as several other new devices. That came just a few months after Amazon debuted a touchscreen version of the smart speaker, the Echo Show.

Among the 41 industries surveyed by the bureau, 27 reported lower industrial production levels but at a much narrower pace in March than the two months of the year.

Among them, 2,820 were established in 2016, the growth rate topping other major cities of China.

Among the top 20 companies on the list, not one saw a greater increase in patents granted this year than Amazon. The Seattle online retail giant won 1,662 patents in 2016, an increase of 46.3 percent. That was enough to bump Amazon up 12 spots on the list?to number 14.