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SAN DIEGO (KGTV) — If you're riding the bus to "Flavortown," there's only one stop in San Diego.Celebrity chef Guy Fieri was spotted at Ocean Beach's Hodad's location alongside owner Shane Hardin, the son of late owner Mike "Bossman" Hardin, on Monday. Pictures from local photographer Jim Grant show the "Diners, Drive-Ins, and Dives" host mingling with the restaurant's crew and taking photos with fans.City of San Diego spokeswoman Alma Rife said the city had issued a "blanket permit," or filming throughout San Diego, for an untitled Food Network program from March 4-7. A Food Network spokesperson was not able to provide comment as to the nature of the filming.RELATED:Inventive eggs Benedict, dumpling soup highlight San Diego's foodie scene on YelpSeven San Diego burritos among the best in the U.S., ranking saysFieri is no stranger to the OB staple. He stopped by on past episodes of "Triple D," once in 2007 for the "Seaside Eats" episode and then again in 2013 for the episode, "All San Diego, All the Time."Hodad's has also been featured in other Food Network specials, including "Top 10 Burgers" and "With Bacon," the latter of which saw Fieri and other chefs dish on their favorite bacon eats.Fieri's kinship with the local burger joint inspired its own Hodad's burger: The Guido Burger, a pastrami-smothered burger with ketchup, pickles, swiss cheese, grilled onions, and spicy brown mustard.Monday, the chef posted a photo on Twitter of one fan's dedication to the delicious land which he coined: 1522

SAN DIEGO (KGTV) — Local leaders say it's going to cost millions of dollars to prevent toxic waste from flowing into the Tijuana River Valley, but it's a bill they are willing to pay. Dozens of local leaders and federal agencies came together this morning with a common goal, to prevent the massive amounts of sewage from flowing into our San Diego County beaches. "427 million gallons of sewage has hit our water and our beaches just this year alone," says Port of San Diego Commissioner, Dan Malcolm. During today's meeting, leaders were given possible solutions on how to tackle the problem. "To divert sewage and wastewater flow away from the Tijuana River Valleys, so that it can either be treated or diverted to outflow pumps, that would pump the water far out in the Pacific Ocean," says Mayor of Coronado Richard Bailey.The costs are estimated up to 0 million. Local leaders say sewage isn't the only contaminate in the water. A chemical test was done that showed things like herbicides, arsenic, and lead are also flowing into the sea. "The time of talk is over," says Serge Dedina, Mayor of Imperial Beach. "The time of actually doing things and preventing sewage and toxic waste from reaching our beach is now."Local leaders say the next plan of action is to ask Congress for help with funding. Mayor Kevin Faulconer and Mayor Serge Dedina will be visiting Mexico over the next few days to talk about solutions to the waste in the Tijuana River Valley. 1475

SAN DIEGO (KGTV) -- If you’re looking for something to do the Friday after Thanksgiving but don’t want to get caught in the Black Friday crowds, county parks is offering an alternative known as Green Friday On Friday, November 23, parking fees will be waived at all county parks and preserves, according to County of San Diego Parks and Recreation. Click here for more information on the free parking. Normally, visitors are charged per vehicle, per day. Check out the list below for more Green Friday offers from the county: 546

SAN DIEGO (KGTV) — It may sound like a scene out of "Jurassic Park," but you'll soon be able to check out more than 70 life-like dinosaurs from your car at the Del Mar Fairgrounds.Jurassic Quest Drive-Thru is bringing back the popular event with a twist, introducing visitors to a drive-thru display of animatronic dinos at the fairgrounds from Jan. 1 to 10 next year.From their vehicles, guests will experience the massive models — from a Tyrannosaurus rex to Triceratops to 50-foot Megalodon — roaring and moving in realistic displays as they drive through the tour. An audio tour guide will lead guests through the hour-long tour.Organizers say attendees will have limited contact, if any, with staff on-site, and that state and local coronavirus precautions will be taken.Tickets start at per vehicle, with the option for "dinosaur surprise" add-ons. All guests will also get a free safari-style photo in their vehicles with dinosaurs in the background to remember their trip.Visits must be purchased for available timeslots. For more information or to buy tickets, visit the event online here. 1110

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

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