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发布时间: 2025-05-26 05:21:01北京青年报社官方账号
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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

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SYDNEY, Aug. 2 (Xinhua) -- Australia's general practitioners ( GPs) will not back the idea of routine prostate cancer tests for men as young as 40 despite growing calls for regular screening, the nation's largest professional general practice organization said on Tuesday.Spokesman for the Royal Australian College of General Practitioners (RACGP), Professor Chris Del Mar said there was not enough solid evidence to suggest major benefits from routine screening and that current tests were unable to detect "nasty" and potentially deadly forms of prostate cancer from ones that will not cause any harm."The problem is you end up treating lots of people who don't need to be treated," Del Mar said, adding that treatment could leave men impotent and with incontinence problems."You will treat 20 times as many people than would have ever been bothered by it. We don't yet know that treating prostate cancer is better than not treating it. We are not sure it does any good and could be doing more harm," he said.On the other hand, Australia's urologists and pathologists both want men aged 40 and over who are worried about developing the disease to be offered tests.The Royal College of Pathologists (RCPA) on Tuesday released an official recommendation on routine screening for men aged 40 and over if they were concerned about prostate cancer.The pathologists argue that blood tests for prostate cancer in men under 50 can predict their future risk of developing the disease by measuring their prostate specific antigen levels (PSA).They say that men with high PSA levels for their age should be tested annually, while those PSA levels are below the average could be tested less frequently.Their call for more routine testing contrasts with recommendations for GPs, whose `Red Book' medical guide does not support regular screening.Instead, it suggests GPs should inform men aged 50-70 of the risks and benefits of screening and only test if the patient requests one.RACGP spokesman Del Mar, who co-wrote the RACGP's recommendations, said while the Red Book was being revised "we are not going to liberalize it".Prostate cancer is one of the most common forms of cancer in Australia.About 20,000 cases of prostate cancer are diagnosed each year, with 3,300 men dying.Given the debate around prostate cancer tests, the Royal College of Pathologists wants to work with GPs, urologists and other medical organizations to develop a consensus on how and when to test for the disease, in a similar way to how experts approach breast cancer."It would be a good outcome for prostate cancer if we worked towards developing more of an umbrella document which reflected consensus among different stakeholder organizations. ," RCPA President Paul McKenzie said.

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RIO DE JANEIRO, July 28 (Xinhua) -- Brazilians are eating a lot of rice and beans as well as high-calorie junk food lacking nutrition, a study released Thursday by the Brazilian Institute of Geography and Statistics (IBGE) found.According to the study, over 90 percent of Brazilians eat daily helpings of fruits and vegetables lower than the levels recommended by the Health Ministry (400 grams). Also,the consumption of sugary drinks (juices, fruit drinks and soft drinks) is twice as high as recommended by the ministry.Rice and beans, along with coffee and juices, are the most popular in Brazilians' diet. Teenagers are the main consumers of those drinks, drinking twice as much as adults. Men eat less greens and fruits than women, but drink five times more alcohol.In urban areas, the consumption of beer, soft drinks, sandwiches, and salty bread is higher. Brazilians in rural areas have a healthier diet, richer in rice, beans, fish, cassava flour, and sweet potatoes.Along with a lack of physical activity, the Brazilians' poor diet was cited as one of the main causes of obesity in the country. According to a Health Ministry study published in April, 48 percent of Brazilians are overweight, and 15 percent are obese.

  

WASHINGTON, July 5 (Xinhua) -- The countdown for the final space shuttle launch began Tuesday afternoon, but unfavorable weather may delay shuttle Atlantis' launch attempt on Friday, NASA announced."We are going with a 60 percent chance of KSC (Kennedy Space Center) weather prohibiting launch due to the potential for showers and isolated thunderstorms in the area," shuttle weather officer Kathy Winters told reporters Tuesday at a precountdown status briefing. "I wish I had a better weather briefing for you."Atlantis is scheduled to lift off at 11:26 am (1526 GMT) on Friday from Kennedy Space Center with four U.S. astronauts on board for a 12-day mission to the International Space Station. Overall, the chance of an on-time liftoff is 40 percent, Winters said."We will do everything we can to launch on Friday but if things don't work out so that we can do that we have plenty of options... Saturday and Sunday," said NASA Test Director Jeremy Graeber. Conditions improve for Atlantis launch opportunities on Saturday and Sunday.NASA said it must launch Atlantis by Sunday, otherwise it will have to wait until at least July 16. That's because of an unmanned rocket due to lift off next week, using the same launch support personnel and equipment.NASA's 30-year-old shuttle program is ending due to high operating costs. The Obama administration wants to spur private companies to get into the space taxi business, freeing NASA to focus on deep space exploration and new technology development.When the U.S. space shuttle program officially ends later this year, the Russian space program's Soyuz capsule will be the only method for transporting astronauts to and from the station.

  

BEIJING, Aug. 16 (Xinhuanet) -- Almost one in four Chinese students aged between 12 and 14 have tried smoking, according to the results of a survey released by the Chinese Association on Tobacco Control (CATC).The survey, carried out among 38,839 students and 6,503 teachers from middle and high schools in 11 provinces across the country between May and June, showed that 22.5 percent of students aged between 12 and 14 had tried smoking and that 15.8 percent of middle and high school students smoke regularly."There are definitely quite a number of boy students in my class who smoke regularly as some have been found smoking outside campus during lunch break," said Li Xiaolan, an English teacher from a high school in Shanghai. The survey also found that 39 percent of students took their first cigarette from their classmates."It was quite common to smoke with my classmates at school and we usually smoked in toilets or in corners of the playground after lunch," said Zhou Guangrong, a 22-year-old university student from Guiyang, Guizhou province, who started smoking when he was 12.The majority of student smokers buy cigarettes themselves and about 76 percent of the adolescent smokers said that there is at least one cigarette shop within 200 meters from their school."When I was a student at middle and high schools, they were surrounded by cigarette shops," said Zhou who used to smoke two cigarettes per day in primary school and two packs per week in middle and high school."We're keen to show that more adolescents are starting smoking much younger than before, and that we need to minimize the number of young smokers," said Duan Jiali, secretary-general of the youth tobacco control commission under CATC. Duan added that teachers and parents should set a good example for teenagers by not smoking in front of them at school or at home, which is the most influential way of stopping adolescents from smoking.China banned smoking in 16 types of public indoor venues - including hospitals, schools, bars, restaurants and hotels - on May 1 in an attempt to curb tobacco use in the country with the world's largest number of smokers.Currently, there are more than 300 million smokers in China, and about 1.2 million people die from smoking-related diseases every year, accounting for one-fifth of the world's total, according to statistics from the World Health Organization."Meanwhile, about 540 million people are exposed to secondhand smoke, 48.9 percent of which are adolescents (from 15 to 19 years old)," said Xu Guihua, deputy director of the CATC."It's essential and urgent for us to control the number of adult smokers who potentially tempt adolescents to smoke."

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