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发布时间: 2025-05-24 07:17:43北京青年报社官方账号
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Jeff and MacKenzie Bezos announced Thursday that they have agreed to divorce terms, with MacKenzie Bezos set to hold on to a chunk of Amazon stock.In a 164

  濮阳东方男科医院网上预约   

It's already starting: Potential candidates for the President's seat in 2020 are picking at each other, and today it was a message from President Donald Trump aimed at Democratic Senator Elizabeth Warren.The President retweeted a meme from The Daily Wire that labels Warren "1/2020th." Warren recently announced she has launched an exploratory committee for her possible run for the role of President in 2020. 421

  濮阳东方男科医院网上预约   

KANSAS CITY — Maureen Boesen has always known cancer risk was high in her family."We're able to really track our history of breast cancer back to the late 1800s and early 1900s," Boesen said. "My grandmother actually passed away from ovarian cancer when she was 44. She had five sisters and none of them lived to the age of 50. Then, my mother was diagnosed with breast cancer when she was 32. We knew there was something going on and that it was a very young age."When Boesen and her two sisters were ages 3, 5 and 7, their mom was already receiving chemotherapy for stage 2 breast cancer. Because of the extensive family history, the girls were part of a study at a university in another part of the Midwest. Their mom was hoping to help the world better understand what was killing so many women. She was hoping to better her daughters' chances for survival."We were all tested in the same exact room," said Boesen's sister, Bridget Stillwell. "I can even remember what the room looked like." Because the girls were so young, and the health threat still likely years away, they wouldn't receive their DNA test results until they turned 18."We knew we were part of a study," Boesen said. "We knew our results were waiting for us, but we didn't know what they were."When asked if she found that wait frustrating, she said emphatically it was not."Quite the opposite. We felt empowered," she said.She didn't get the results right away. The sisters knew there was nothing they could likely do at age 18 even if their test results showed they'd inherited the BRCA gene mutation. The sisters all waited until they were around age 21. One sister was positive. One sister was negative. Boesen remembers meeting with the researcher to learn her results."We sat down and we had a conversation about what BRCA was and what it meant for my family," Boesen said. "It was a lengthy conversation, which made me very uncomfortable because why would a conversation that wasn't going to change my life last that long?"Eventually, the researcher told her she had inherited the gene mutation."It was just devastating because I knew what breast cancer and ovarian cancer can do to a family. You know, my first question out of my mouth was, 'Is there any chance this could be wrong?' The researcher said 'No.' "Boesen walked out of that meeting determined. She was going to make decisions to save her own life. She was going to have a bilateral prophylactic mastectomy. She would schedule a surgery to remove both breasts to prevent breast cancer."This was me doing what I was supposed to do and this was me being empowered and me being proactive and not waiting until I have a cancer diagnosis," Boesen said.She didn't want to feel like a ticking time bomb. She wanted to live.Boesen had the surgery to remove both breasts when she was just 23 years old. She went on to get married and have three children."I didn't get to breastfeed them. It was sad. I'm not brokenhearted or devastated about it, but it is sad to think I couldn't provide for my children like that," she said.At the time, she still believed she'd made the right decision because she was healthy.Once done having children, she knew there was another step that most people with the dangerous BRCA gene mutation have to consider."I knew that when I was done having children, I needed to have a complete hysterectomy," Boesen said.The BRCA gene mutation not only dramatically increases a woman's chance of developing breast cancer at a young age, it also significantly increases a woman's chance of ovarian cancer."The right thing to do and what the doctors say to do is have a complete hysterectomy by the age of 35 and I was in my early 30s," Boesen said.In 2018, she went to a hospital in Kansas City, Missouri, to start the process of preparing for her hysterectomy. Both her health care provider and her insurance company wanted a new DNA test. Everyone knew what the results would be, but they went through the motions to get the required confirmation she was positive for the deadly gene mutation which was so rampant in her family.The test results were supposed to be back in a few weeks, but it had been four and Boesen was starting to worry. Then, she got the call from the doctor."I was at work. And the first thing she said was, 'We need to talk', and my heart just sank," Boesen said. "She said, 'You're negative,' and I just started bawling."She was overwhelmed, confused and full of emotions."I was angry. I was regretful. I was happy. I was sad. I so desperately wanted to feel relief, 'Oh, thank God, this is the best day of my life,' but it wasn't," Boesen said. "It was just devastating."Boesen got another test to confirm the second test results. It also came back negative.She did not get the hysterectomy. There was no need now. There was no longer a threat that cancer was waiting to explode in her body. She now knew she had not inherited the BRCA gene mutation that had killed so many of her relatives.Dr. Jennifer Klemp of the University of Kansas Cancer Center has worked in the field of cancer genetics, specifically breast and female cancers, since 1997. She is the director of Cancer Survivorship and a cancer risk counselor. While she was not involved in Boesen's original research, she says she's not surprised."Twenty years ago, when we sent our first tests and BRCA 1 and 2 were the two genes we tested for, about 30-40 percent of the time we would get something called a 'variant of uncertain significance,' " Klemp said. "Basically, that meant we found a mutation or an error in the DNA, but we didn't know if that was associated with an increased risk of cancer. Today, using a reputable lab, that should be less than 1-2 percent."Klemp says things are changing rapidly in the field of genetic testing. If someone had a DNA test more than five years ago, they should consider having an updated test. She also says the at-home tests are good for finding out details about your ancestry, but they shouldn't be used to make major decisions about your health. For that, you'd want a health professional to order a commercial test through a certified, reputable lab. With more and more companies offering testing, and more medical professionals and patients interested in genetic testing for so many reasons, she says demand right now is outpacing supply."If you have 10 different labs doing testing, and you have every primary care, OB-GYN, oncology clinic, surgical clinic and any number of patients eligible for testing, it's a little bit of the wild west," Klemp said, adding there's no central repository for this patient and test information.As for Boesen, the university where the original research was done and the false positive originated offered to re-test her DNA. She is currently waiting on the results from what is now her fourth genetic test. She hopes it comes back negative, too, which is what the experts all expect. She believes, then, finally, she'll be able to move forward with her life. Boesen and her two sisters are writing a book about their experiences. Each of her sisters has a story to tell, too. Their book will be titled, " 7146

  

It used to be that learning happened in the classroom, but these last few months it’s happened a lot in front of a screen. Many parents have debated about how much screen time is too much and what’s best as school comes to a close and we hit the summer break. Now, some experts say that thinking screen time is bad might be old-school thinking. Video games have changed a lot since the days of Atari Pong. Now, more than ever, they’re designed to keep the consumer engaged. One of their biggest targets: adolescents. "Video games have classically been more of a problem because once you really engage that reward system, it’s frustrating and tough to pull kids off," said psychiatrist Joel Stoddard.He said that’s because a child’s reward system is stronger than a child’s control system. And there’s a difference in the way the brain reacts to video games than it does to the online schooling. "For most of the video games that kids are really into, like Fortnite and Zelda: Breath of the Wild, those games are designed to really engage their reward systems and keep their attention. So, that’s a little bit different than online school, which is not really designed in the same way to grab hold of those areas in the brain that are involved in like ‘this is what I want’," said Stoddard. "When kids are engaged with a teacher or with academic content online, that serves a very different purpose than playing a video game or having a zoom call to socialize with a peer," said Jennifer Walsh-Rurak, Vice President of the Northeast Region of Fusion Academy. That interaction, whether it’s playing video games with friends online, or FaceTiming, is better than no interaction. "In this day and age where they can’t naturally go outside and engage with kids in the neighborhood, we don’t want to discourage them from having that social peer interaction which we know is so critically important," said Walsh-Rurak. Stoddard says the extra time on the screens, isn’t all bad. It can actually be beneficial to an extent."The brain gets better at doing what it does so, when we’re interacting with screens all of our visual and screen areas are getting better. If you’re gaming, maybe some of those special attention and those reward areas get more sensitive, if we’re doing social media we’re going to be highly attuned to what does that ‘like mean, what does it not mean’. The brain just gets better at what it does," said Stoddard. However, it’s important to think about what else the kid could be doing instead of playing on the screen. "We do know that video games can suck kiddos in so they’re not actually having normative typical social interactions. They might gain weight, for example, and have disrupted sleep. And those have that sort of knock-on effects," said Stoddard. "I think proactively before it gets to that point, ensuring that kids have time built into their day where they plan to be outside maybe walking the dog, engaging with a family member in a conversation, reading a book. Doing something that very intentionally takes them away from that screen," said Walsh-Rurak. 3102

  

It's supposed to be one of the happiest days of your life. But brides in the Kansas City area said they spent their big days stressed out because their hair and makeup artist didn't show.One of those brides was Miranda Reeves, who started planning her wedding last summer. While searching online, she came across 324

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