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SAN DIEGO (CNS) - The Collaborative Clinical Trials Unit at UC San Diego has been selected to lead and administer an international seven-year, million grant for HIV/AIDS clinical trials.The National Institutes of Health selected UCSD, along with other American, South African and Indian research hospitals, as part of its seven-year HIV/AIDS funding renewal. Every seven years, NIH competitively renews its funding of the HIV clinical trials networks operating in the United States and internationally.During the current application process, the UC San Diego AntiViral Research Center, University of Colorado Hospital, Houston AIDS Research Team and Durban International clinical research sites were chosen to work collaboratively on research priorities for the NIH/National Institute of Allergy and Infectious Diseases HIV/AIDS Adult Therapeutics Clinical Trials Network.The Chennai Antiviral Research and Treatment Center, University of Southern California and University of Miami clinical research sites were also chosen to join UCSD to serve as qualified reserve or protocol-specific sites as needed for future clinical trials."UC San Diego has helped shape HIV/AIDS research and treatment through innovative research since the inception of the adult and pediatric therapeutic clinical trials networks in 1986," said principal investigator Dr. Constance A. Benson, director of UCSD's Antiviral Research Center."Together, the seven clinical research sites selected by the NIH for the HIV therapeutic clinical trials network bring together a wealth of scientific expertise, experience and the high quality performance required to conduct complex clinical trials," she said.Abouty 38 million people are living with HIV/AIDS globally, with 1.7 million acquiring HIV in 2019 alone. In the United States, 1.2 million people are living with the virus.The UCSD-led clinical trials unit serves several regions in the United States burdened by chronic and new HIV infections as well as global regions impacted by both HIV and tuberculosis.The unit will investigate therapeutic strategies aimed at a cure for HIV, including evaluating viral persistence, researching antibody approaches to treatment and prevention and investigating treatment of inflammation and its impact on HIV comorbidities.In addition, investigators will study new drugs including long-acting drug formulations for HIV treatment and prevention, HIV-related coinfections and comorbidities -- including metabolic and end organ complications and a hepatitis B cure, as well as the treatment and prevention of tuberculosis, including TB preventive vaccines, in persons with mono- and HIV-coinfection."We are honored to lead a talented pool of investigators in a common goal of advancing research that clinically benefits people living with HIV," Benson said. 2830
SAN DIEGO (CNS) - The San Diego City Council voted unanimously Monday to expand city-imposed curfews on five local parks in North Park, City Heights and near Balboa Park. The vote will establish a midnight-to-6 a.m. curfew at Cedar Ridge Mini Park, Montclair Neighborhood Park, North Park Community Park and North Park Mini Park and a 9 p.m. to 5 a.m. curfew at City Heights Square Mini Park. The council added curfews to the five parks after residents expressed concerns about people breaking the law after-hours on park grounds. The city does not currently have a blanket park curfew, which would make it illegal to be in a park after a certain time, but many of the city's parks generally close at or some time after sunset. Multiple City Council members expressed concern that the curfews could unfairly target homeless residents. North Park, City Heights and areas adjacent to Balboa Park currently have a significant portion of the city's homeless population. "This is about trying to address legitimate public safety concerns," said City Councilman Chris Ward, who represents the district encompassing all five parks. "A huge focus of mine is to make sure that this is not inappropriately used to criminalize homelessness." With the vote, the five parks will join Children's Park, Gaslamp Square Park, Pantoja Park, the Children's Museum Park, Fault Line Park, Cortez Hill Park and the Spruce Street Pedestrian Bridge as public spaces with overnight curfews. 1473

SAN DIEGO (CNS) - San Diego County will remain in the "red" tier of the state's COVID-19 reopening plan, state officials said Tuesday, citing data on the two metrics California uses to adjust counties.The county is reporting 6.9 new daily cases per 100,000 population, just .1 away from the dreaded "purple" tier, the state's most restrictive. San Diego County is also posting a 3.8% positive testing rate for the novel coronavirus -- well within the lower "orange" guideline of the state's four- tier reopening system.This news comes as somewhat of a surprise after increasing COVID-19 numbers appeared to set the county on a path toward slipping into that most restrictive tier -- which would shutter indoor operations for restaurants, movie theaters, houses of worship and gyms, limit retail businesses to just 25% capacity and have major impacts on indoor business for most other industries until the county can improve its numbers.The county Board of Supervisors met multiple times in the last few days to discuss taking potential action should that happen, including legal action. Gov. Gavin Newsom rejected a county effort Wednesday to discount the more than 800 positive tests recorded by San Diego State University since the semester began.The data released Tuesday did factor in SDSU cases. The push to exclude them was an unlikely gambit in the first place, as SDSU is located in a highly residential neighborhood in the heart of the city."We included the San Diego State University numbers we received in all of our calculations," state Health Secretary Dr. Mark Ghaly said. "We've worked closely with San Diego County over the past, not just last week, but really intensely over the last week to make sure we all understood the data and that we understood where the county landed in the framework. There were no concessions made based on their data. And we looked closely at San Diego State, the same way we do all of the other counties across the state."Despite the good news about remaining in the red tier, Ghaly noted that the county is hovering on the brink of being downgraded. The state rules currently state that a county has to be above one of the two metrics -- daily case rate by population and positive test rate -- for two consecutive weeks before it can be moved. To move down to less restrictive tiers, both of those metrics must be below state guidelines for two consecutive weeks. Should the county be placed in the purple tier, it would have to wait a minimum of three weeks before moving back to less restrictive tiers.Ghaly said San Diego County would stay in red for this week, but he could not make any promises for the week after if case numbers rise again."We certainly see a county that is hovering around that threshold between red and purple, but we continue to have conversations about how we at the state can support San Diego, as well as understanding more and more what San Diego is doing around places like San Diego State University to curtail or limit transmission," he said.To facilitate expanded COVID-19 testing at San Diego State University, the county testing site at Mar Vista High School in Imperial Beach will be temporarily closed through Friday. Testing there will resume Sept. 28.Testing capacity at the SDSU Alumni Center at 5250 55th St. is being expanded from 500 to 1,000 tests a day and will be open to the public, students and university staff. The no-appointment site will offer testing from 8:30 a.m. to 4 p.m. through Friday.As of Monday night, SDSU had reported 880 confirmed or probable cases, including two reports of faculty or staff who have tested positive.The San Diego County Board of Supervisors passed a motion Tuesday to show their support for County Public Health Officer Dr. Wilma Wooten in her efforts to work with the state.The board voted to support Dr. Wooten's effort for "the adjudication and revised reopening criteria to accurately reflect the dynamics of the pandemic in San Diego County."Many of the supervisors felt aside from daily cases of COVID-19, other factors like hospitalization rates, the case rate adjustment factor and special circumstances should be considered before rolling back any progress in reopening.It began with Board Vice Chair Jim Desmond making a motion to write another letter to the governor asking for local control in reopening. After discussion, he changed his motion for the board to back Dr. Wooten to work with the state in revising the criteria.The vote passed 4 to 1 with Supervisor Nathan Fletcher dissenting.Though the vote board showed their support for Wooten and her efforts in working with the state, it's unclear if it will lead to any change.County public health officials reported 348 new COVID-19 infections and no new deaths Monday, raising the region's total cases to 44,925 with the death toll remaining at 760.Of the 6,374 tests reported Monday, 5% returned positive, bringing the 14-day rolling average of positive tests to 3.7%.The seven-day daily average of tests is 8,440.Of the total positive cases reported as of Sunday, 3,418 -- or 7.6% -- required hospitalization and 801 -- or 1.8% -- had to be admitted to an intensive care unit.One new community outbreak in a restaurant was confirmed Monday. From Sept. 14-20, 22 community outbreaks were confirmed.The number of community outbreaks remains above the trigger of seven or more in seven days. A community setting outbreak is defined as three or more COVID-19 cases in a setting and in people of different households over the past 14 days. 5544
SAN DIEGO (CNS) - The father of two children who died in a Rancho Bernardo condominium fire fell asleep while drunk with a lit cigarette in his hand and then abandoned his kids to try and save himself, a prosecutor said Tuesday, while a defense attorney told jurors that a defective cell phone was a far more likely ignition source. Jurors heard final summations, then began deliberating the charges against Henry Lopez, 39, who is charged in the Oct. 28, 2017, deaths of his 7- year-old daughter Isabella and 10-year-old son Cristos. He faces up to 14 years in prison if convicted of involuntary manslaughter, child endangerment and reckless fire starting. Deputy District Attorney Kyle Sutterley alleges that Lopez got drunk following an argument with his girlfriend, fell asleep and ignited a blaze in his bed. The prosecutor alleges that Lopez, upon waking to find the condo ablaze around 3:15 a.m., went past the children's bedrooms on his way down the stairs and punched out a first-floor window to try and escape the flames. He then went back upstairs and started pounding on the walls, then passed out from the smoke at the top of the stairs, where firefighters later found him, Sutterley said. According to the prosecutor, Cristos walked into his father's burning bedroom, laid down on the floor and died of burns to more than 80 percent of his body. Isabella went into her brother's room, laid down on the bottom bunk bed and ``fortunately never woke up'' after passing out due to smoke inhalation, Sutterley said. ``A parent has a responsibility to care for their children, a responsibility to protect their children, and if need be, to sacrifice themselves for their children. And Henry Lopez, on Oct. 28, 2017, he failed his children, and as a result, one of them burned to death, and one of them went to sleep and never woke up,'' Sutterley said in his closing argument. Defense attorney Paul Neuharth Jr. alleges it was more likely that his client's iPhone 6 caused the blaze while it was charging beneath Lopez's pillow. Neither cigarette butts, nor the phone, were found in the remnants of the blaze. Sutterley said investigators located a drinking glass within the area where the fire started, which may have been used as a makeshift ashtray. Prosecutors say a similar glass full of around 75 discarded cigarette butts was located in a trash can in the home's garage. However, no cigarette butts were found inside the glass in the bedroom. Neuharth told jurors there was no proof that a lit cigarette started the fire, with the only evidence of smoking inside the home coming from the defendant's ex-wife, Nikia, who said she once witnessed him smoking marijuana in his bed. Lopez told investigators he only smoked on his outside patio and never inside the house, particularly due to his son's asthma. Wayne Whitney, an investigator with the San Diego Fire Rescue Metro Arson Strike Team, testified last week that despite the lack of cigarette butts in the burned bedroom, he was able to make a ``reasonable inference'' that cigarettes sparked the fire, by way of Lopez's alleged smoking habits. Whitney conceded that the cell phone was a possible cause of the fire, but said he didn't believe it would have ignited the condo fire if it were under Lopez's pillow, as a lack of oxygen would have smothered the blaze and kept it from spreading. Sutterley said the burns Lopez sustained on his back, arms and particularly his hand were more consistent with holding a lit cigarette, rather than a cell phone igniting beneath his pillow, which Sutterley argued should have caused burns to Lopez's head. Neuharth emphasized that Whitney came to his conclusion despite no evidence that Lopez smoked in the home that day, while on the other hand, cell phone records proved the phone was in the condo, though it's unknown whether it was in Lopez's bedroom. Wall outlets and candles in Lopez's bedroom were ruled out as potential causes of the blaze, as they were outside the area where investigators believe the fire began. Smoke detectors in Lopez's bedroom and one of the children's rooms were unplugged or removed, according to Sutterley, who said Lopez had a 0.229 blood-alcohol content when blood was drawn at a hospital less than two hours after the fire. Neuharth contested the idea that Lopez did not do whatever he could to try and save his children, telling the jury that the defendant went back upstairs and beat a hole in the wall in attempt to get to the youngsters' rooms amid thick smoke filling the condo. The attorney argued that had it not been for the timely arrival of firefighters, Lopez, too, would have died from smoke inhalation. ``What more can you ask of a parent than to give their life and if not for whatever matter of seconds it would have been or a minute before he was brought out and resuscitated, he would have been dead along with the children,'' Neuharth said. Sutterley argued Lopez's first instinct was selfishness and self- preservation, as ``he was so deep into a bottle of whiskey and a cigarette that he forgot (the children) were there or abandoned them on purpose. But either way, as a parent, your first thought is to save your children. Your first thought is to your kids. It's not to yourself. It's not to the front door. It's to save your children.'' 5315
SAN DIEGO (CNS) - The San Diego Convention Center will light its Sails Pavilion orange beginning at sundown tonight and Sunday in recognition of World Homeless Day, city officials said.San Diego Mayor Kevin Faulconer said millions of people around the world experience homelessness every day.``San Diego has made great strides over the past few years to invest in solutions that get people into safe, sanitary conditions and on a path to a permanent home,'' the mayor said. ``We continue to make progress during this pandemic with 600 people and counting getting housed through Operation Shelter to Home.''The convention center was turned into an emergency homeless shelter on April 1.``Our Sails Pavilion will shine orange for World Homeless Day to acknowledge the needs of people who experience homelessness and how different communities are responding,'' said Rip Rippetoe, CEO and president of the convention center.``Especially during this time when our most vulnerable San Diegans face COVID-19, we are grateful to our community for coming together and successfully implementing Operation Shelter to Home.''The first World Homeless Day was held a decade ago. 1172
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