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It’s hard to regard Ellie as a menace.When Greg Manteufel is frustrated or feeling down, she sits by him. At night, she sleeps under his covers. At dinner, she’s there next to him, knowing he’ll throw something her way. She belies the stereotype of the vicious pit bull.“We love her like she’s our daughter,” he said of the dog.And yet, Ellie may be the reason Manteufel nearly died.Gravely ill, he lost parts of his arms and legs, as well as the skin of his nose and part of his upper lip. The cause was capnocytophaga (cap-noh-seye-TOE’-fah-gah), a germ from Ellie’s mouth or from another dog he encountered.Capnocytophaga is commonly found in the saliva of cats and dogs and almost never leads to people getting sick, unless the person has a compromised immune system. But Manteufel was perfectly healthy. In fact, he doesn’t think he’d ever used his health insurance before he fell ill.The case is extremely rare and doctors at his hospital, Froedtert & the Medical College of Wisconsin, had no explanation for why he got so sick. But over the last 10 years there have been at least five other healthy people who have had severe reactions to the germ. A team of researchers connected with Harvard Medical School has developed a theory on why — a gene change in all the victims.And their finding means doctors can’t rule out the capnocytophaga bacteria could strike Manteufel and other victims again.___Greg Manteufel thought he was getting the flu in June of 2018. He had a fever, vomiting and diarrhea. But when he started getting confused, his family took him to the hospital.Doctors did blood cultures and found capnocytophaga, which caused sepsis, a severe blood infection that led to his blood pressure dropping and many of his organs shutting down.“Do what you have to,” he told the doctors.He had so much to live for — foremost, his wife of 16 years, Dawn, and 26-year-old son, Mike. He was just starting to get really good at his day job, painting houses. He cherished his Harley Davidson Electric Glide. He was in the middle of fixing up his ’66 El Camino. And of course there was Ellie, the pup.And so he persisted, through more than 20 surgeries, including amputations of his left and right arms just below the elbow, and legs through the middle of the knee.His wife and son stayed optimistic, because he was.“Greg said he didn’t come this far to lay down and let this beat him,” Dawn Manteufel said.He was out of the in-patient rehab unit in about two weeks, learning to move from his wheelchair to the bed, toilet and car. The usual stay is three to four weeks, said Dr. David Del Toro, medical director for the inpatient rehab unit at Froedtert.Manteufel made similar quick advances using his arm prosthetics and leg prosthetics.“He does not seem like any other patient I’ve met before,” Del Toro said. “He’s just, you know, full speed ahead.”Meanwhile, researchers at Brigham and Women’s Hospital in Boston, connected to Harvard Medical School, as well as Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center had been investigating cases like his.The team has done genetic testing on five otherwise healthy people who suffered capnocytophaga infections to see if they could find anything in common. They discovered all had a gene connected to the immune system that was working differently — a genetic variant.“It was a really thrilling moment,” said Elizabeth Fieg, a genetic counselor at Brigham and Women’s Hospital. “The stakes are so high with these cases and the patients have gone through so much.”They believe it makes those people more susceptible to developing severe medical problems from capnocytophaga. But they are also trying to determine if there are other risk factors.Of the five in the study, three survived with amputations and two did not. Fieg hopes their research can determine why some did not survive.She also hopes if their theory is confirmed, it will help diagnose cases faster, and perhaps save lives and limbs.That’s why Greg Manteufel jumped at the chance to take part when he was approached in August.Researchers need to gather more evidence, but hope to publish their study in the next year to 18 months.___Manteufel’s life now includes frequent occupational therapy appointments to perfect his use of arm prosthetics — the kind with metal moveable hooks at the end. He’s using a fork regularly and he’s now working on picking up the TV remote, opening doorknobs, cutting vegetables and doing the dishes.He’s using shortened leg prosthetics, called stubbies, to get his body conditioned to eventually use to full-sized ones. Those are expected to arrive any day.Plastic surgeons plan another surgery to perfect his nose. They’ve already moved skin from his forehead there. It looks oversized now, but it will eventually fit in with the rest of his face.He plans to get his car revamped so he can drive with prosthetics. He wants to get a special pole so he can go fishing again. He is even considering going back to work painting.He’s also become less quiet and a lot more outgoing. “Now everybody I see wants to hear something or talk to me. I tell them a 15-minute story about what happened. They probably want me to leave, you know,” he said, chuckling.Ellie’s often by his side.“She loves kids. She loves puppies. Other dogs,” Manteufel said.As harmless as she seems, she may have capnocytophaga germ.The results of Manteufel’s genetic tests are expected in three to four months. Fieg said people with the gene variant are at increased risk for recurrent capnocytophaga or other infections in the future.While Manteufel doesn’t like the sound of that, he said Ellie’s accidentally scratched him since he’s been home and even licked his mouth. He’s been fine.And even if he does have the gene variant, he said, it changes nothing.“We didn’t even bother testing her,” said Manteufel. “We weren’t going to get rid of her if it was her that caused it anyway.”“We just love her to death.” 5972

Just when stores started filling their toilet paper shelves again, other items are suddenly in short supply. Most of them have nothing to do with cleaning.You'll recall that first it was hand sanitizer and Lysol wipes that became impossible to find back in February — which feels like it was three years ago in the time-dilated Twilight Zone of 2020.March arrived with face mask and toilet paper shortages, and cleaning sprays and products disappeared from store shelves.April brought the first shortages of beef, chicken and pork as processing plants shut down.As those items get restocked, other wells are running dry.Newer items that are getting hard to findBike shops across the country have been so busy during the pandemic that it's almost 758

Kellogg is getting out of the cookie business to focus on snacks and cereal.Ferrero will buy Kellogg's Keebler cookies, Famous Amos, Mother's, Murray's, Girl Scout cookies and fruit snacks brands for .3 billion. Ferrero makes Nutella, Tic Tacs and Ferrero Rocher chocolates among other confectioneries.Kellogg has been trying to 343

If you lived in the western half of the United States, it might not have been obvious, but the month marked one of the warmest February months on record globally.According to data released by NOAA on Monday, last month marked the fifth-warmest February globally since record keeping began in 1880. While western North America had a comparably cooler February, the eastern US, Europe, South America, Asia and Oceania all recorded above average temperatures. Last month's global temperature was nearly 2 degrees above the average 20th century average. NOAA also reported retreating ice levels in both the Arctic and Antarctic Arctic sea ice was 5.9 percent less than the 1981-2010 average. Antarctic sea ice decreased by 13.4 percent compared to 1981-2010 averages. While the debate among non-scientists continues on climate change, the NOAA data shows that globally, the Earth is still in a warming pattern, and sea ice is decreasing. And despite record-breaking cold in the Eastern US in late January, the December-February averages for the region have been slightly above average. 1094

Last night, DARPA launched 3 balloons from Cumberland, Maryland, in a flight test for the Adaptable Lighter Than Air prgm. Over next few days, ALTA will demonstrate capability for wind-borne navigation of a lighter-than-air vehicle over extended ranges. https://t.co/Og8dWCvszc pic.twitter.com/NjUB6Got94— DARPA (@DARPA) June 18, 2019 346