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DOHA, Jan. 18 (Xinhua) -- Government should forge close ties with its people and listen to their opinions, Chinese Premier Wen Jiabao told reporters when asked his opinion on the situation in West Asia and North Africa.Wen said he made it clear during talks with Gulf states' leaders that government should respect the people's appeals in defending their own interests, for it is the people who created history. The responsibility for any government is to bring benefits to its own people, he added.In today's information-rich world, governments face more complexity in governing, and policy and planning coordination. In such circumstances, people's demands on government are also growing, Wen said.By keeping close ties with its people and listening to their opinions, governments could better develop the economy, improve people's livelihoods and bring benefits to them, he said.A responsible government should firmly and bravely shoulder its responsibility without pursuing special gains for itself, Wen said.

WASHINGTON, Dec. 21 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Wednesday approved Isentress for the treatment of HIV-1 infection for children and adolescents.The drug is part of a class of medications called HIV integrase strand transfer inhibitors that works by slowing the spread of HIV in the body. It was first approved for use in adult patients in October 2007, under FDA's accelerated approval program."Many young children and adolescents are living with HIV and this approval provides an important additional option for their treatment," said Edward Cox, director of the Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research.Isentress is a pill that can be taken twice daily, with or without food. The pill is also available in a chewable form. As the two tablet formulations are not interchangeable, the chewable form is only approved for use in children ages 2 to 11.A single, multi-center clinical trial of 96 children and adolescents aged 2-18 years with HIV-1 infection evaluated the safety and effectiveness of Isentress. These patients previously received treatment for HIV-1 infection. After 24 weeks of treatment with Isentress, 53 percent of these patients had an undetectable amount of HIV in their blood.According to the FDA, the most commonly reported severe, treatment-related side effects in patients taking Isentress include trouble sleeping and headache. The frequency of these side effects is similar for children and adults. One pediatric patient reported severe treatment-related insomnia, while another pediatric patient experienced a drug-related skin rash.

WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Jan. 20 (Xinhua) -- China will regulate the production and sale of cosmetic colored contact lenses by including them in its list of items classified as "medical apparatus."Some people wear such non-corrective colored contacts to change or enhance eye color for cosmetic and fashion purposes.As these contacts are not for vision correction and medication purposes, they are currently off limits to the country's medical administration and regulators, said a statement published on the website of the State Food and Drug Administration on Thursday.However, with the increasingly popular use of cosmetic contacts, safety and quality problems due to the regulation loophole are likely to harm consumers' health, and the administration has decided to expand the current medical regulation on contact lenses to cover cosmetic ones, the statement said.It explained that the administration will soon issue a notice to ban the manufacture and sale of these contacts without proper registration and licenses.The statement also warned consumers of the risks of these contacts and suggested they carefully choose and use such products.

BEIJING, Nov. 28 (Xinhuanet) -- A majority of the emergency hospitalizations for bad events related to medication use in old U.S. adults stem from four common medications, according to a new study in the New England Journal of Medicine Monday.The study was conducted by researchers from the Centers for Disease Control and Prevention of U.S.There are nearly 100,000 emergency hospitalizations for adverse drug events in older Americans, says researcher Daniel S. Budnitz, MD, MPH, director of the CDC's Medication Safety Program.And the four types of medication -- two for diabetes and two blood-thinning agents -- account for two-thirds of those drug-related emergency hospitalizations. They most often cited: warfarin (Coumadin, Jantoven); insulin; antiplatelet drugs such as aspirin and clopidogrel (Plavix); oral hypoglycemic agents."Both blood thinners and diabetes medicines are critical drugs that can be lifesaving," Budnitz says.However, he says that ''these are medications that you do need to pay attention to," being sure the dose and timing are correct, among other measures.

来源：资阳报