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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

OTTAWA, Oct. 26 (Xinhua) -- Canadians are working about three years longer before retirement than they were in the 1990s, and have a longer life in retirement, an official study said Wednesday.Statistics Canada, the federal statistics agency, reports that Canada' s men and women, who don't face compulsory retirement, are increasingly choosing to delay retirement, as part of a long-term trend that has begun before the recent recession.The trend of later retirement dates back to the mid-1990s, when a 50-year-old employee could expect to work another 12.5 years before retiring from the daily grind.Today, that same 50-year-old worker could expect another 16 years of employment.The study says that 34 percent of Canadians aged 55 and older were employed in 2010, compared to just 22 percent in 1996.A longer working life would unnecessarily imply a shorter life in retirement due to increased life expectancy, the study says.The study notes that men and women leaving the work force today are spending as much time in their post-career life as many of their predecessors did.For example, between 1977 and 1994, the typical retirement length for a man in Canada rose from 11.2 to 15.4 years; as of 2008, it was 15 years.For women, the average retirement length similarly rose from 16.4 to 20.6 years between 1977 and 1996; as of 2008, it was 19 years.From another point of observation, 50-year-old men can expect to spend 48 percent of their remaining years of life in retirement in 2008,compared with 45 percent in 1977.In 2008, 50-year-old women could expect to spend 55 percent of their remaining years of life in retirement, nearly identical to the proportion in 1977.

ISLAMABAD, Oct. 24 (Xinhua) -- Samina, 38, was shocked when doctor told her that she has been suffering from breast cancer for three years and due to late diagnosis the disease spread into her bones making the chances of survival very slim.Samina said that she is trying hard to fight the disease, at the same time she holds the doctors of her village responsible for failing to diagnose the disease in three long years. She is also concerned about her three kids too young to accept any bitter reality."I can't see the distressed faces of my children, I can't bear the fear that looms in their eyes, they know that with every coming day their mother is moving a step forward to death," Samina told Xinhua in a very low tone.When Samina and all other patients of that gloomy medical ward for breast cancer patients, in Nuclear Medicine Oncology and Radiography (NORI) hospital in Islamabad, were told that October is being observed as breast cancer awareness month they murmured that the awareness message should be reached to every nook and corner of the country this year so that no other woman would die due to unawareness.In a country like Pakistan where one in nine women is prone to breast cancer and around 40,000 women die every year due to lack of awareness of this disease. They come to visit oncology department of hospitals at a stage when the chances of survival are very remote.Omer Aftab, National Coordinator of the Pink Ribbon, said that Pakistan has the highest rate of breast cancer among Asian nations. It is the most common malignancy in women, and accounts for 38.5 percent of all female cancer patients, with 90,000 new cases every year.

BEIJING, Oct. 1 (Xinhua) -- China plans to decrease leprosy rates by 50 percent over the next 10 years, according to a joint plan to fight the infectious disease issued by the Ministry of Health and ten other ministerial-level institutions.The prevalence rate is targeted to be brought down to one case per 10,000 people by 2015. The rate will further shrink to one in every 100,000 people by 2020 in at least 98 percent of the country's counties, according to the plan.A total of 500,000 cases of leprosy have been reported and treated for free throughout the country since the founding of the People's Republic of China on Oct. 1, 1949.The number of leprosy cases has plummeted over the past 62 years, but the country still faces challenges in fighting the disease, the plan said.Leprosy, an infectious disease that has affected humanity for over 4,000 years, is primarily characterized by skin lesions and progressive physical debility, and can cause permanent nerve damage.Despite sustained efforts -- and considerable success -- in bringing the disease under control, leprosy is still a serious disease in some parts of China and people who have been cured of the disease continue to face discrimination.More than 1,700 new cases have been reported annually in the past five years. The provinces of Sichuan, Yunnan, Guizhou and Hunan and the Tibet Autonomous Region are most affected by the disease, according to the plan.