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As wildfires rage in California, emotions are heating up.“People are not getting along,” said Boulder Creek, California, local Alex.In the Santa Cruz mountains, people are stocking up on gas but running out of patience.“The whole valley was closed,” Alex said. “Closed man!”At the local grocery store, workers are counting every single cent after being shut down for two weeks due to fire concerns.“We definitely have stocked up on our gallon waters,” said Vanessa Russo, owner of Wild Roots Market in Boulder Creek.Russo says wildfires during the pandemic have drastically cut into profits and are now weighing on people’s wallets and their well-being.“A lot of our customers are having to deal with refrigeration issues and slowly having evacuations be lifted,” she said.With thousands of homes destroyed during these fires and many businesses already suffering due to COVID-19 concerns, rebuilding could come at a cost never seen before.“The 2020 fire could be even more catastrophic than say the 2018, which was I think was billion,” said Janet Ruiz with the Insurance Information Institute.Ruiz says the California fires could impact areas across the country.“Agriculture, you talk about the wine industry,” she said. “Beef, the pork, all those could be affected by catastrophe.”The economic impacts of these fires stretch from the mountains, all the way to the ocean“So, the time when our businesses need funding from us, we don’t have it to give,” said Bonnie Lipsco-mb, director of economic development for the City of Santa Cruz.Fire displaced Lipscomb’s family and they’re now living in a trailer.”Despite the new digs, Lipscomb is still focused on helping her community during these unprecedented times.“The impact is really catastrophic,” she said. “I don’t think we’ve seen this since the earthquake and maybe not even then.”With much of the city’s budget funded through sales and property taxes, areas of income that were already suffering before the fires, city leaders are now seeking support from state and federal government agencies.“We’re working on long-term recovery, but at the same time, it's day by day,” Lipscomb said.That road to economic recovery, however, will be long and costly. 2221

AstraZeneca is the latest drugmaker to announce promising Phase 3 trial results from its COVID-19 vaccine candidate.On Monday, AstraZeneca said its two-shot vaccine candidate has been 90% effective thus far along with no safety concerns.“These findings show that we have an effective vaccine that will save many lives," said Professor Andrew Pollard, the chief executive of the study. Excitingly, we’ve found that one of our dosing regimens may be around 90% effective and if this dosing regime is used, more people could be vaccinated with planned vaccine supply. Today’s announcement is only possible thanks to the many volunteers in our trial, and the hard working and talented team of researchers based around the world.”The company added in its press release that its vaccine candidate offers two distinct advantages over vaccines made by Pfizer and Moderna — it's cheaper to produce, and does not need to be stored in ultra-cold conditions before use.AstraZeneca added that the company would "immediately" prepare regulatory paperwork to seek Emergency Use Listing status from the World Health Organization.AstraZeneca is just the latest drug company to report encouraging results from its COVID-19 vaccine candidate.Last week, Pfizer said it had submitted Emergency Use Authorization paperwork to the Food & Drug Administration (FDA) after a final analysis of its vaccine candidate proved to be 95% effective in preventing COVID-19. The FDA is expected to approve the drug in the coming weeks.Moderna has also said that early results show its vaccine candidate to be 95% effective, and is on track to have the drug approved for Emergency Use Authorization by the end of the year.AstraZeneca, Pfizer and Moderna are all shattering records for vaccine development. The three vaccines are all on track to be approved for widespread use in uder a year. Typically, it takes several years for a vaccine to go from development to approval.The announcement comes as COVID-19 is spreading around the world at a rate not previously seen since the pandemic began. And while all three companies are pre-producing their vaccines in the hope that it will be approved, health experts warn that they won't be widely available until spring 2021. 2247

As officials try to put together a picture of the alleged synagogue shooter, one focus of the investigation is his social media postings, a federal law enforcement official told CNN. Here's what we know so far about the suspect Robert Bowers, 46:He allegedly made anti-Semitic statements after his arrestThe shooter made anti-Jewish comments during the incident, a law enforcement official told CNN. The shooting took place on the same day as Saturday Shabbat services. At the time of the shooting, three different congregations were holding services at the Tree of Life facility.In one post, he said he "can't sit by and watch my people get slaughtered" 662

At least 71 people were killed and 325 others wounded in rebel-held Eastern Ghouta after the Syrian government carried out a series of airstrikes and artillery bombardments, the UK-based Syrian Observatory for Human Rights said Monday.Sixty-two of the victims were civilians, including nine children and five women. Nine militants were killed, the group said of the attacks near Damascus over a 24-hour period.CNN could not independently verify the claim.The Eastern Ghouta area has been surrounded by Syrian forces for more than four years, with the siege intensifying last May when government forces conducted a large-scale offensive.It was supposed to be one of the "de-escalation zones," according to the peace agreement struck by Russia, Turkey and Iran in May 2017.About 400,000 Syrians have been killed since the conflict erupted in 2011, according to the United Nations. As many as 5.4 million Syrians have left their country, the UN Refugee Agency said, and 6.1 million are displaced from their homes but still inside Syria. The UNHCR High Commissioner, Filippo Grandi, calls the situation in Syria "the biggest humanitarian and refugee crisis of our time."The-CNN-Wire? & ? 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved. 1270

As the COVID-19 pandemic progresses, researchers say it is important to track how the coronavirus mutates because it could affect the efficacy of a vaccine.Like all living cells, viruses evolve their chemical make-up changes. In viruses like the flu, that happens frequently, which is why every year there is a new vaccine to treat whatever strain is expected to circulate. With COVID-19, however, those mutations happen much slower, according to research out of Arizona State University.“One of the things we’re still keeping an eye on is the evolution of this virus because that virus is still around in the community,” said Dr. Efrem Lim, an assistant professor at ASU. “Everyone is coming in blind to this. This is a novel virus. This isn’t something we have seen before.”In March, Arizona State University played host to our country’s fourth COVID-19 case. As soon as it was detected, Dr. Lim started studying how the virus mutates and sent his findings to the World Health Organization. It's something that still continues to this day.“This virus, overall, mutates pretty slowly, which is a good thing,” said Dr. Lim. “However, we can have instances where the virus can have very large, dramatic, mutations, such as deletions in the genome.”While rare, Dr. Lim says those mutations can be significant as it changes how the virus acts inside the body.Currently, scientists are focusing much of their efforts on identifying ways to eliminate the function of the spike protein in COVID-19, as it is the way the virus binds to our cells and infects them (spike proteins are the stalks that protrude from the center of the virus that make it so recognizable).“It is very good news that the virus is not changing rapidly,” said ASU virologist Dr. Brenda Hogue. “We will have to see over time, as the virus continues to circulate, as we put a vaccine into play, whether or not there will be any issues.”Dr. Lim says right now there does not appear to be any issues because the virus mutates slowly, but he adds it could adapt to a vaccine once one begins to circulate.He says more testing needs to be done to determine that, however. 2140

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