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WASHINGTON, June 16 (Xinhua) -- Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage.Their findings will be published Friday in journal Science. Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage.The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage -- double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities.The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms."SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress."SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.

BEIJING, Aug. 14 (Xinhua) -- Gary Locke, the newest U.S. ambassador to China, promised on Sunday to promote bilateral cooperation and understanding between the two countries.Acknowledging challenges in the "important and complex diplomatic and economic bilateral relationship" between the two countries, Locke said he looks forward to working with the Chinese government to expand bilateral cooperation and collaboration.He made the remarks at a press conference held on Sunday afternoon, his first public appearance since arriving in Beijing on Friday evening. Locke's wife Mona Lee and their three children accompanied him at the conference.Speaking about the things he hopes to accomplish over the next several months, Locke said the most important thing will be "to promote stronger and better understanding between the U.S. and China.""This must be done so that more people in the United States understand China, its history, its contributions to world civilization, its challenges and the amazing progress China has made in such a short time," he said.Locke also stressed China's "unique history, culture, and philosophy," which he said must be understood if the two countries wish to forge a more cooperative relationship.Locke, a Democrat, was elected as Washington state's 21st governor in 1996, becoming the first Chinese-American governor in U.S. history. He won reelection in 2000. President Obama nominated Locke as Commerce Secretary in February 2009.

COPENHAGEN, May 29 (Xinhua) -- The number of confirmed E.coli cases has risen to 11 with at least another eight persons suspected of having the intestinal infection in Denmark, according to Denmark's National Serum Institute on Sunday.Five of the confirmed cases show symptoms of kidney failure which marks an advanced stage of the sickness, the institute said.Danish cucumbers are suspected of helping spread the E. coli bacteria believed to be causing a deadly outbreak of intestinal infection in Denmark and Germany, local media reported Sunday.The Danish cucumbers were mixed in Germany with cucumbers originating in the Netherlands, making it difficult to determine if Danish cucumbers are in fact contaminated.Denmark's Veterinary and Food Administration (DVFA) had earlier said the suspicion against Danish cucumber was "vague", but advised Danish consumers not to eat raw tomatoes, lettuces and cucumbers from Germany, and cucumber from Spain.It is now checking Danish cucumbers for traces of E. coli with results expected on Tuesday.Some Danish retailers have now removed these products from their supermarket shelves. And the Danish branch of fast-food chain McDonald's announced Saturday that it was dropping fresh cucumbers from its menu until further notice.The infection, which is food-borne, can be caused by eating raw or uncooked foods such as vegetables contaminated with the E. coli bacteria.Symptoms of infection include mild fever, bloody diarrhea and vomiting, and can last five to seven days. It can prove fatal in the very young, sick, or elderly.

CANBERRA, Sept. 1 (Xinhua) -- Bushranger Ned Kelly's headless body has finally been identified in Australia, more than 130 years after his execution in the Old Melbourne Gaol, Victoria's Attorney- General Robert Clark announced on Thursday.Clark said the bushranger's remains have been identified by doctors and scientists at the Victorian Institute of Forensic Medicine (VIFM).Kelly was an Irish Australian bushranger, considered by some merely a cold-blooded killer, while by others a folk hero and symbol of Irish Australian resistance against oppression by the British ruling class for his defiance of the colonial authorities. He was hanged for murder in 1880 at Old Melbourne Gaol. His daring and notoriety made him an iconic figure in Australian history, folklore, literature, art and film.The project involved collaboration with the ancient DNA laboratory EAAF in Argentina, which has worked with the VIFM on other forensic projects.Clark said "This is an extraordinary achievement by our forensic team here in Victoria," he told reporters in Melbourne on Thursday."To think a group of scientists could identify the body of a man who was executed more than 130 years ago, moved and buried in a haphazard fashion among 33 other prisoners, most of whom are not identified, is amazing." The investigation started when a skull believed to belong to Kelly was handed to the VIFM on Nov. 11, 2009.The skull handed in in 2009 was found not to be that of Ned Kelly, and Glenrowan historian Gary Deans said the next step is to find Kelly's skull."The Government should put a request in the public arena for the return of Ned Kelly's skull," he told ABC News."We know thanks to Jack Cranston, who held the skull around 1929, that it was sitting on a detective's desk. This was around the same time that remains were dug up in the Old Melbourne Gaol."I imagine that that detective or somebody else took it home."

JERUSALEM, July 25 (Xinhua) -- A new study carried out by a Tel Aviv University researcher indicates that the common backache may not only be caused by bad positions or aging, but also by your genes.Prof. Gregory Livshits of the Sackler Faculty of Medicine says that genes play a major role in back pain, especially in the lower back, and in spinal deterioration.In a decade-long project with 2,500 identical and non-identical twins, Livshits found that, in one Arab family, the same back problems appeared in all the members of the family, whether young or old.According to the study, non-identical twins were three times more likely to have back pain, while identical twins were six times more likely to have the same back problems.Livshits believes the discovery of the link between back pains and genes could lead to much better treatment.The research was developed in collaboration with a team of scientists at Kings College, London, led by Prof. Tim Spector and Dr. Fran Williams and was recently published in the journal " Annals of the Rheumatic Diseases."In order to better investigate the genetic causes for one of the world most common pains, Livshits and his colleagues hope to put together an international consortium of research groups.