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Today we filed a statement in support of Epic's request to keep access to the Apple SDK for its Unreal Engine. Ensuring that Epic has access to the latest Apple technology is the right thing for gamer developers & gamers https://t.co/72bLdDkvUx— Phil Spencer (@XboxP3) August 23, 2020 296

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

Top officials at the Justice Department, the FBI and the Office of the Director of National Intelligence agreed Monday to share highly classified information with lawmakers related to the Russia investigation amid an escalating controversy over the bureau's use of a confidential intelligence source during the 2016 presidential campaign.White House press secretary Sarah Sanders said Monday that chief of staff John Kelly planned to "immediately" schedule a meeting with the officials and leaders of Congress to "review highly classified and other information they have requested."But the statement -- vague enough to allow each side to claim victory -- did not fully settle the critical issue: whether the Justice Department would ultimately be forced to turn over the documents subpoenaed by House Intelligence Chairman Devin Nunes on the FBI source.Sanders had said earlier that Deputy Attorney General Rod Rosenstein, FBI Director Christopher Wray and Director of National Intelligence Dan Coats were expected to gather at the White House on Monday afternoon for a discussion aimed at addressing congressional requests.Rosenstein, Wray and several other officials were spotted leaving the White House just before 4 p.m. ET after over an hour inside. The Justice Department did not comment on the meeting or details of the agreement.While Sanders and a source familiar with the meeting said it had been scheduled before a weekend of tweets from President Donald Trump, it took on a heightened public focus Monday afternoon.On Sunday, Trump demanded via tweet the Justice Department "look into whether or not the FBI/DOJ infiltrated or surveilled the Trump Campaign for political Purposes."His tweets prompted the Justice Department to ask its inspector general to expand its ongoing probe into the surveillance of former Trump campaign aide Carter Page to include a review of whether the FBI was politically motivated in its investigation of Russian meddling in the 2016 US election, Justice Department spokeswoman Sarah Isgur Flores said in a statement Sunday."If anyone did infiltrate or surveil participants in a presidential campaign for inappropriate purposes, we need to know about it and take appropriate action," Rosenstein said in the statement.Some former Justice Department and FBI officials praised the move as deftly avoiding a ugly showdown, while others lamented that Rosenstein had failed to stand up to the President.But tapping Inspector General Michael Horowitz to examine the issue appeared to de-escalate the controversy, at least for now.Vice President Mike Pence praised the decision during an interview with Fox News set to air later Monday."The President I think is grateful that the Department of Justice is going to have the inspector general look into it, and determine, and insure, that there was no surveillance done for political purposes against our campaign," Pence said.How House Intelligence Chairman Devin Nunes and other Republicans on Capitol Hill handle the apparent agreement for another classified briefing remains to be seen.Nunes said Sunday that he would refuse to meet with the Justice Department unless he was able to review documents related to the confidential FBI source.Rep. Adam Schiff, of California, the ranking Democrat on the House Intelligence Committee, said he's unaware of what the administration briefing on the confidential source is about, whether they'll see documents and whether he'll be invited. He's concerned that the Justice Department may have "capitulated" despite its concerns that revealing the information could put lives at risk.Schiff also expressed concern about Kelly or other White House officials at the upcoming meeting getting access to sensitive materials related to the ongoing investigation.The New York Times and The Washington Post?have reported the source spoke to Page and Trump campaign co-chairman Sam Clovis, as well as campaign adviser George Papadopoulos.Clovis' attorney, Victoria Toensing, told CNN on Monday that the source had reached out to Clovis but her client "didn't know this guy from Adam.""Russia didn't even come up," Toensing added, saying the meeting was about China and took place around the end of August or early September 2016.Page tweeted what he indicated was an email from the source in July 2017, describing their interactions as "cordial," but CNN has not independently confirmed the email's authenticity.Trump has previously suggested the intelligence source was "embedded" in his presidential campaign, but US officials have denied that claim to CNN. 4642

Today has been a trying day for our family. We’re thankful to everyone who has reached out with their concerns. Our daughter is in good care at Arnold Palmer Hospital and is doing well. My wife was also treated for her injury and has been released from the hospital. At this time, we ask for privacy as we focus on our daughter’s recovery. 347

Three UCLA basketball players accused of shoplifting in China last week returned to Los Angeles on Tuesday.Video showed the three freshmen greeted by a media scrum as they walked out of a Los Angeles International Airport terminal about 6 p.m. (9 p.m. ET).US President Donald Trump earlier said he asked his Chinese counterpart to help in the case. 356

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