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WELLINGTON, May 24 (Xinhua) -- New Zealand researchers have found a way to stop the growth of certain cancer tumors by " silencing" a group of PAX genes, members of a small family of genes that play important roles in embryonic development, but also allow cancer cells to grow and divide in adult tissue.In an article published in UK medical journal Oncogene, Otago University Professor Michael Eccles and colleagues revealed how they used the PAX8 gene to kill cancer cells.After detecting high levels of PAX8 protein in the majority of kidney, ovarian and thyroid cancers they studied, the researchers used molecular techniques to silence the PAX8 gene in several cancer cell lines."We found that these PAX8-depleted cancer cells ceased growing and dividing. The cells were essentially stopped in their tracks through the failure of multiple mechanisms and pathways crucial to their cell division cycle. They then entered into a state called senescence in which they no longer divided, and after that they ultimately died," Eccles said in a statement from the university Tuesday.The findings suggested that PAX8 could be a good target for the development of new cancer therapies, he said."Any resulting drugs would be a long way down the road, but in the meantime this research helps confirm that a focus on PAX genes may prove to be a fruitful line of attack against a number of cancers," he said.The research was supported by grants from the Health Research Council of New Zealand. It formed the main piece of work carried out by Otago doctoral graduate Caiyun (Grace) Li, now a postdoctoral fellow at Stanford University. Study co-authors also included Professor Antony Braithwaite and master's student Jen Nyman.In 2003, research led by Eccles discovered that proteins from one or more of the nine PAX genes were present in many common cancers. They found that "silencing" the gene expression of PAX2 in ovarian and bladder cancer cells, and of PAX3 in melanoma, led to the rapid death of the cells.

BEIJING, Feb. 12 (Xinhua) -- China's recent revocation of a national scientific award due to academic fraud has been welcomed by the public, but experts warn the country still has a long way to go to bring an end to such dubious academic practices.On Feb. 1, China's Ministry of Science and Technology, revoked the State Scientific and Technological Progress Award (SSTPA) given to Li Liansheng, former professor of Xi'an Jiaotong University in 2005.An investigation found Li had plagiarized others' works and fabricated data in his winning project, a research on key technologies for designing and manufacturing scroll compressors. Li was investigated after the science ministry received tip-offs from six professors (including four retired) in his university.The ministry subsequently canceled his prize and retrieved the money awarded.Zhao Baojing, a senior official with the National Office for S&T Award, told Xinhua it was the first time China had withdrawn a national scientific honor.The revocation soon sparked pubic discussion over academic integrity. Tan Gang, a citizen in Shenzhen, wrote on his microblog, "Though the revocation came a bit late, it is progress. It's a warning against academic misconduct."Shi Ying, vice director of Shanxi Academy of Social Sciences, said, the move demonstrated China's "zero-tolerance" for academic fraud, and would help clean up the academic field."However, academic fraud is still rampant, which not only damages academic integrity, but also harms the innovative capacity of China in a broader sense," said Shi.Anti-fraud activist Fang Zhouzi, who runs a website on anti-academic fraud from his Beijing home, said "This is by far the harshest stance China has ever taken against academic fraud, which should be viewed as progress." He so noted China still has a long way to go in the fight against academic fraud.Fang said, the science ministry's move does not mean China is really cracking down on academic fraud. The plagiarist might have not been found out if it were not for years of unyielding efforts made by the six professors.The scandal again highlights that academic fraud is alive and well in China. A survey conducted among 30,078 respondents in 2009 by the China Association for Science and Technology (CAST) showed that nearly half of the science-related workers in China's research institutes, universities, medical institutes and hospitals think academic cheating is "common."Fang attributed the prevalence of academic fraud in China to lax punishments and loopholes in the academic evaluation system.Zero tolerance of academic fraudChina's science minister, Wan Gang, said on several occasions "We hold zero tolerance for academic fraud."However, Fang said "zero tolerance" was a slogan rather than the actual case. Many cases of academic fraud, even publicly exposed, were "tolerated" eventually. "Lax punishment makes academic fraud less costly."

WASHINGTON, Jan. 20 (Xinhua) -- Visiting Chinese President Hu Jintao on Thursday called upon the U.S. Congress to continue helping the two countries boost their relations.Pursuing a healthy and steady development of China-U.S. ties is China's established policy and strategic choice, Hu stressed in talks here with Speaker John Boehner of the House and Majority leader Harry Reid of the Senate.It has also been the consensus of the U.S. administrations, whether Republican or Democratic, since the two countries established formal diplomatic relations 32 years ago, he added.Chinese President Hu Jintao (2nd L front) meets with U.S. Senate Majority Leader Harry Reid (2nd R front) on Capitol Hill in Washington, the United States, Jan. 20, 2011Thanks to the two nations' concerted efforts, the China-U.S. relationship has been moving forward steadily, Hu said, citing the two countries' increasing cooperation and coordination on trade, terrorism, climate change, Korean Peninsula denuclearization and other bilateral, regional and global issues.A sound relationship between Beijing and Washington not only serves the fundamental interests of both peoples, but greatly contributes to the peace, stability and prosperity of the Asia-Pacific region and beyond, the Chinese president said.With China and the United States differing in culture, social system and development level, it is normal for the two sides to have differences on some issues, he said.But what matters most is the common interests of the two countries, he stressed, saying that Beijing's position is that the two sides should seek common ground while reserving differences, so as to learn from each other and pursue common prosperity on the basis of mutual respect and equality.

WASHINGTON, April 11 (Xinhua) -- Taking a statin before having major elective surgery reduces potentially serious kidney complications, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology.Each year, more than 230 million major elective surgeries are performed around the world. Unfortunately, many patients who undergo major operations develop kidney injury soon after surgery, often due to decreased blood flow to the kidneys and/or the effects of inflammation.Animal studies suggest that the cholesterol-lowering drugs called statins protect the kidneys from such damage, but whether a similar benefit occurs in humans is uncertain. To investigate, Amber Molnar, University of Western Ontario, and colleagues conducted a population-based retrospective study of all older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. Surgeries included cardiac, thoracic, vascular, intra-abdominal, and retroperitoneal procedures.A total of 213,347 patients from 211 hospitals underwent major elective surgery, and 4,020 patients (1.9 percent) developed postoperative kidney injury within two weeks of surgery. A total of 1,173 patients (0.5 percent) required dialysis within two weeks of surgery, and 5,974 patients (2.8 percent) died within a month of surgery.Prior to surgery, 67,941 patients (32 percent) were taking a statin. Patients taking a statin were 20 percent less likely to develop kidney injury, need dialysis, and die compared to patients who were not taking a statin. Also, there was evidence of a dose-effect, with patients on higher potency statins having less kidney injury. In addition, statins were beneficial whether they were started greater than 90 days or less than 30 days prior to surgery."Our study suggests that statin use in older persons results in less kidney injury following major elective surgery and reduces the risk of premature death after surgery," said Molnar, adding that the results warrant further investigation with more rigorous studies, but such trials will be difficult to carry out.

BEIJING, Jan. 30 (Xinhua) -- Chinese Vice Premier Li Keqiang Sunday urged scientists to learn from foreign experiences and increase their participation in international cooperation in polar and oceanic exploration.Li made the remarks after meeting with members of China's 27th Chinese Antarctic expedition team, the 22nd oceanic expedition, and scientists working in the country's Antarctic and Arctic stations via video and telephone.Li said many countries nowadays attached great importance to polar and oceanic exploration, and international competition had grown in promoting the peaceful utilization of these resources.Chinese Vice Premier Li Keqiang (R, front) shakes hands with a senior Chinese explorer in Beijing, capital of China, Jan. 30, 2011. Li conveyed Spring Festival greetings while meeting with members of China's 27th Chinese Antarctic expedition team, the 22nd oceanic expedition, and scientists working in the country's Antarctic and Arctic stations via video and telephone on Sunday."We are confident and capable of constantly improving our working conditions to conduct polar and oceanic exploration, and winning the initiative in this sector's future development," Li said.Li said the country would work to promote its marine economy and safeguard marine ecosystems, as well, and make full use of the achievements made in explorations to make reasonable development and utilization of ocean resources.China would also ensure the security of ocean passages, and safeguard its marine rights and interests, the vice premier said.Li also conveyed New Years greetings to the scientists for conducting research away from their homeland and families, and applauded their contribution to the country's progress in polar and oceanic research areas.

来源：资阳报