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President Donald Trump's hasty announcement last week that he'll slap new tariffs on steel and aluminum imports has prompted a public free-for-all to finalize details of the plan, with efforts underway to assuage some concerns from within Trump's own party.Trump insisted on Monday that he wouldn't back off his promise to apply a 25% tariff on steel and a 10% tariff on aluminum. But there are indications the plan isn't yet finalized and that whatever is ultimately announced may be narrower in scope than initially previewed.Speaking with Prime Minister Justin Trudeau on Monday evening, Trump signaled he was flexible in how the proposed tariffs would apply to Canada, a person close to the trade talks said. During a conversation with British Prime Minister Theresa May on Sunday, Trump indicated he had not made a final decision on what to do with steel and aluminum tariffs, according to person familiar with the call.  939

Republican Darrell Issa has represented the 49th Congressional District for nearly 20 years, but new signs are pointing to a Democrat taking that House seat in the November election.Republican Diane Harkey is vying for the position against Democrat Mike Levin. The district runs from coastal North San Diego County into Southern Orange County. Speaking to the Republican Party of San Diego County at an event this month, Harkey said some are losing hope in her campaign. She rallied attendees at the Town and Country Resort on keeping the 49th a Republican seat. After an enthusiastic response, she told the crowd: 637

Retailers and carriers are preparing for an online holiday shopping surge that could tax shipping networks and lead to delivery delays.FedEx and UPS are ramping up their holiday hiring while expanding their weekend operations and asking retailers to use their shipping network when there is more slack. And stores are pushing shoppers to buy early and are expanding services like curbside pickup to minimize the need for delivery.For the last few years, many retailers had been using their own physical stores, in addition to their distribution centers, to fulfill online orders. But now they are designating some of those stores to handle even higher volumes. Best Buy, for example, converted space in 250 of its 1,000 stores this fall to manage online orders.The moves come as most of the carriers have been at full shipping capacity for months as shoppers shifted their buying online during the pandemic.“We are warmed up for what we’re calling the ship-a-thon,” said Brie Carere, chief marketing and communications officer at FedEx. “Like everything else in 2

Recent Vanderbilt University graduates who made a germ-resistant phone case after contracting COVID-19 have now sold 1,000 cases. They are donating as many cases to health care workers."Now that they have them in their hands, just the positive response we have been getting is just something that we weren't fully expecting," said Nick O'Brien.RELATED: College seniors create germ-resistant copper phone case after recovering from COVID-19After contracting the novel coronavirus, Nick O'Brien, Isaac Lichter, and Andrew Medland founded Aeris and created their first product, a copper-coated phone case."Copper is very effective at continuously killing germs, a whole variety of microbes including the novel coronavirus," said Isaac Lichter.In a matter of months, the entrepreneurs who graduated from Vanderbilt, moved to San Diego and are now producing their product on an industrial scale. They are able to fill orders as soon as they come in and make good on their promise to donate a case to a healthcare worker for each one purchased.On Friday, Aeris donated phone cases to Vanderbilt University Medical Center."I am very excited to see what these 250 healthcare workers have to say," said Lichter.Next, the company plans to donate cases to hospitals in their hometowns, including New York City and San Diego.Aeris is working on new designs that incorporate copper."We see the future as copper-covered," said Lichter. "We knew we didn't want to be a phone case company. We see the real value in this."WTVF's Hannah McDonald first reported this story. 1562

Researchers published what they say is the first case of a living person diagnosed with the degenerative brain disease chronic traumatic encephalopathy or CTE.While unnamed in the study, lead author Dr. Bennet Omalu confirmed to CNN that the subject of the case was former NFL player Fred McNeill -- who died in 2015.Omalu is credited with first discovering CTE in professional football players. Until now, the only way to diagnose the disease is with a brain exam after death.The diagnosis was first made using an experimental brain scan that can trace a signature protein of CTE called tau. The authors then confirmed the diagnosis with an autopsy. The case study was published in the journal Neurosurgery this week.'It looked like just depression'Omalu first presented these findings exclusively to CNN's chief medical correspondent, Dr. Sanjay Gupta, in 2016. McNeill's wife, Tia, and his two sons, Gavin and Fred Jr., told Gupta then that they saw Fred transform from a fun loving family man at the center of their lives into a man who was dealing with symptoms of memory loss, anger and depression that tore their family apart."There are some times where the father is the stronghold in the family, or the anchor. If you lose that, everything kind of falls apart. That's kind of what happened for us. It looked like financial issues at first; it looked like marital issues, and they separated; then it looked like just depression," Gavin told Gupta.CTE is known for plaguing people with Alzheimer's like symptoms such as memory loss, rage, mood swings, and in some cases, suicidal ideation.Severity of the disease is categorized into four stages, with stage 4 being the most severe. While researchers don't know exactly why certain people develop the disease and others don't, they believe that it results from repeated blows to the head that trigger a build up of tau proteins in the brain.CTE has been called football's "concussion crisis," however experts point out that CTE can develop from any repeated head injury. According to the Boston University CTE Center, "this trauma includes both concussions that cause symptoms and subconcussive hits to the head that cause no symptoms." These subconcussive hits can include the repeated trauma the brain experiences from constant plays, hitting the turf, and tackling. Wrestlers, boxers, and military troops have also been diagnosed with the disease.Seeing CTEWhile McNeill is the first case to be confirmed with an autopsy, the experimental technology has been used on at least a dozen other former NFL players, including Pro Football Hall of Famer, Dallas Cowboy Tony Dorsett. Omalu helped develop and is invested in the diagnostic exam, which uses a radioactive "tracer" called FDDNP to bind to tau proteins in the brain. The tau proteins can then be seen on a PET scan of the brain.Critics have said the protein also can highlight another protein called amyloid, which may be indicative of Alzheimer's or other forms of dementia. But Omalu noted that in CTE, tau makes distinctive patterns in the brain. It has a "specific topographic signature," he said, and that pattern can be detected in imaging.Omalu said he and his team are currently raising money to start a phase 3 clinical trial to further test the technology and replicate what they have seen in McNeill. He anticipates that once funds are raised, it will take another two to three years for the trial and then another year, at least, for approval from the US Food and Drug Administration. When asked, how soon a commercial test could be available, Omalu predicted it could be as soon as a few years. "We are looking at less than five years," he said.  3711

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