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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

By JOYCE M. ROSENBERG and KEN SWEET AP Business WritersNEW YORK (AP) — Americans are likely to see more "for rent" signs in the coming months. That's because many businesses devastated by the coronavirus pandemic are expected to abandon offices and storefronts. The changes are happening because more employees are working from home, and more people are shopping online. The result could bring an end to the long boom in the nation's commercial real estate market. Hotels, restaurants and stores that closed in March have seen only a partial return of customers. Many of them may fail. Commercial landlords have reported an increase in missed rent payments. They expect vacancies to rise through the end of the year. 724

BURIEN, Wash. – Scott Mandella is a detective in Washington state. He is part of the harm reduction unit with the Burien Police Department, which operates a little differently than what most think of when they think of cops.Tara Moss is the project director for LEAD King County.“LEAD is a program that addresses public health and public safety needs with direct service, harm reduction framework and long-term engagement with individuals,” said Moss.LEAD started in Seattle in 2011 and operates in 30 cites across the U.S. It’s a program which has social workers work with law enforcement to help keep people out of jail and minimize their interactions with police.“They think they’re a good fit for LEAD, they can make a decision to divert that individual into case management services, if they agree to do so. So, instead of arresting someone and putting them in jail, they do a warm hand off, handing off to a case manager who does outreach and engagement with that individual,” said Moss.Does that sound familiar? Groups across the country have proposed defunding or abolishing the police. This model is what a lot of them are talking about.“You throw a cop at someone drinking in the park, and if someone still had that alcohol addiction, we’re going to keep going back to the park over and over and over again,” said Ted Boe, the police chief in Burien.He says his department was first in line to sign up for the LEAD program when the opportunity presented itself. He says it was time for the city to try something else.Bridget Scott is a case worker with LEAD.“Addiction or some of these other issues is not a straight line, and you can’t just tell somebody you’re going to be sober from tomorrow on, but realizing there’s going to be some zig zagging along the way,” said Scott.We spent an hour with Bridget looking for some of her clients, but didn’t find any.So, we met up again with Detective Scott Mandella. He’s worried about making sure one Burien resident gets to the hospital safely.“Gary. Gary, your brother’s here, and you’re going to be all right,” said Mandella.One of the people who called in the incident was the mayor of Burien, Jimmy Matta, who just happened to be running errands nearby. His family deals with a lot of the same issues other residents deal with.“My uncle is an alcoholic, and exactly what I’ve just seen here is what I end up doing with him, so these are real issues and even though I’m an elected official, you know I’m just like everybody else, what I can do for my uncle. My father passed away in Burien, Washington, of a drug overdose, heroin overdose,” said Matta.Everyone from the mayor to the cops, to the social workers, to the residents of Burien is tired of trying the same old thing: arresting people with substance abuse and mental health problems and hoping the problem goes away. They’re hoping this new way gives them a chance. 2892

CAMBRIDGE, Mass. – The U.S. government will pay Moderna Inc. up to .525 billion to secure 100 million doses of the company’s COVID-19 vaccine candidate.The U.S. Department of Health and Human Services (HHS) and Department of Defense (DoD) made the announcement Tuesday.HHS says Moderna will manufacture the vaccine doses while clinical trials are still underway to expedite the traditional development timeline and get vaccines to the public as soon as possible.The Trump administration hopes to deliver the vaccines by the end of the year, so long as the U.S. Food and Drug Administration (FDA) authorizes their use.“In creating a vaccine portfolio for Operation Warp Speed, the Trump Administration is increasing the likelihood that the United States will have at least one safe, effective vaccine by 2021,” said HHS Secretary Alex Azar. “Today’s investment represents the next step in supporting this vaccine candidate all the way from early development by Moderna and the National Institutes of Health, through clinical trials, and now large-scale manufacturing, with the potential to bring hundreds of millions of safe and effective doses to the American people.”HHS says the vaccine doses will be delivered to government-designated locations across the country and the U.S. could acquire up to an additional 400 million doses of the vaccine.If viable, the vaccines would be available to the American people at no cost, according to HHS. Healthcare professionals could charge for the cost of administering the vaccine, though.The vaccine, called mRNA-1273, has been co-developed by Moderna and scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The third phase of the vaccine trial, which began July 27, is the first government-funded Phase 3 clinical trial for a COVID-19 vaccine in the nation, according to HHS.“We appreciate the confidence of the U.S. government in our mRNA vaccine platform and the continued support,” said Stéphane Bancel, Moderna’s Chief Executive Officer. “We are advancing the clinical development of mRNA-1273 with the ongoing Phase 3 study being conducted in collaboration with NIAID and BARDA. In parallel, we are scaling up our manufacturing capability with our strategic partners, Lonza, Catalent and Rovi, to address this global health emergency with a safe and effective vaccine.” 2402

CHICAGO, Ill. – McDonald’s says it’s giving away 10,000 free McRibs to fans who show off their clean-shaven face or smooth skin.To claim a free sandwich, McDonald’s says you must post a photo of your cleanly-shaven or baby-smooth face on your public Twitter or Instagram profile, using #Shave4McRibSweepstakes and tag @mcdonalds. Stories do not count.The first 10,000 entries will receive a code for a free McRib, available via McDelivery with Uber Eats, while supplies last. The chain says anyone can participate, “from your brother to your mother, sister-in-law or cousin’s roommate.”McDonald’s says the promotion began Monday and it’s in honor of the return of the McRib on Wednesday, as well as the end of No-Shave November, a month-long challenge where participants are asked to put down their razors and “get hairy" in the name of cancer awareness.No-Shave November is also a nonprofit devoted to fundraising for cancer research, prevention and education. McDonalds is collaborating with the organization and will make a donation to the charity’s cancer initiatives using the profits from McRibs on Wednesday.“Our bearded fans know… facial hair and the McRib just don’t mix—believe me, I’ve tried,” said Vice President of U.S. Communications, David Tovar. “With the nationwide return of the McRib, we’re helping fans enjoy every delectable moment by encouraging them to shave for a chance to win a free McRib. And we’re excited this year to partner with No-Shave November, a charity that knows a thing or two about facial hair.”“We’re thrilled McDonald’s is supporting this important cause, getting both the bearded and the non-bearded involved beyond November simply by purchasing a McRib,” said Senior Executive Director of No-Shave November, Monica Hill. 1771

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