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WELLINGTON, May 24 (Xinhua) -- New Zealand researchers have found a way to stop the growth of certain cancer tumors by " silencing" a group of PAX genes, members of a small family of genes that play important roles in embryonic development, but also allow cancer cells to grow and divide in adult tissue.In an article published in UK medical journal Oncogene, Otago University Professor Michael Eccles and colleagues revealed how they used the PAX8 gene to kill cancer cells.After detecting high levels of PAX8 protein in the majority of kidney, ovarian and thyroid cancers they studied, the researchers used molecular techniques to silence the PAX8 gene in several cancer cell lines."We found that these PAX8-depleted cancer cells ceased growing and dividing. The cells were essentially stopped in their tracks through the failure of multiple mechanisms and pathways crucial to their cell division cycle. They then entered into a state called senescence in which they no longer divided, and after that they ultimately died," Eccles said in a statement from the university Tuesday.The findings suggested that PAX8 could be a good target for the development of new cancer therapies, he said."Any resulting drugs would be a long way down the road, but in the meantime this research helps confirm that a focus on PAX genes may prove to be a fruitful line of attack against a number of cancers," he said.The research was supported by grants from the Health Research Council of New Zealand. It formed the main piece of work carried out by Otago doctoral graduate Caiyun (Grace) Li, now a postdoctoral fellow at Stanford University. Study co-authors also included Professor Antony Braithwaite and master's student Jen Nyman.In 2003, research led by Eccles discovered that proteins from one or more of the nine PAX genes were present in many common cancers. They found that "silencing" the gene expression of PAX2 in ovarian and bladder cancer cells, and of PAX3 in melanoma, led to the rapid death of the cells.

JAKARTA, April 27 (Xinhua) -- Marine scientists will begin conducting an ecological survey in eight locations throughout the resort island in Indonesia's Bali province that could be developed as marine managed areas due to their biodiversity and coral structure, the Jakarta Post quoted an expert as saying on Wednesday.The survey, which will take place from April 29 to May 11, will be carried out by four international scientists and local scientists from universities.Ketut Sarjana Putra, the marine program director with Conservation International Indonesia, said Tuesday the survey was aimed at identifying marine species and their population in each of the eight locations.Selected from 25 potential marine conservation zones, the eight locations are Pulaki and Pemuteran, Lovina, Les Village, Tulamben and Amed, Padangbai, Nusa Penida, Bukit Uluwatu Peninsula and Perancak Beach. "We will go around Bali, starting from Sanur in the south, heading east, then covering the northern and the western areas, then back to the south," Ketut told the daily.The survey is part of a process to build a network of marine protected areas to effectively manage the island's marine and coastal resources to sustain environmental and socioeconomic value and benefits, with priority given to the eight locations.

SAN FRANCISCO, April 4 (Xinhua) -- Web exploit toolkits, or " packaged" attack frameworks that can be traded online, are rapidly growing as the top cybercrime weapon due to ease of use and high success rate, a new report has found."When it comes to conducting online crime, exploit toolkits are the weapon of choice for many cyber criminals," said the "2010 Top Cyber Security Risks Report" published by Hewlett-Packard Co. (HP) on Monday.The trend started in 2006 with the release of WebAttacker, considered by many to be the first modern day web exploit toolkit, according to the report.An emerging trend ensued and soon took off, and today the Internet is subjected to hundreds of exploits originating from these toolkits."With the ever-increasing, web-based criminal activity, the number of exploit toolkits has skyrocketed and shows no signs of slowing down," the report stated.Though protecting against attacks originated with web exploit toolkits is becoming increasingly difficult, there are ways to minimize the risk of infection, said the report, noting that one of the most effective defenses is to install patches onto host systems.The report also found that while the number of attacks against known vulnerabilities continues to rise, the number of discovered vulnerabilities has plateaued in 2010."We've discovered that rather than investing resources to uncover new exploits, attackers are focused on current, unpatched vulnerabilities in web applications, social networking sites and Web 2.0 interfaces," Mike Dausin, a manager at HP Digital Vaccine Labs, said in a statement.Data from the report showed that nearly half of all reported vulnerabilities exist in web applications, and third-party plug- ins to content management systems have become the leading cause of web application vulnerabilities.