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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — It's sure to be a super summer next year in Del Mar.The San Diego County Fair announced its 2020 season will be themed "Heroes Unite!" when the fair soars into the Del Mar Fairgrounds from June 5 to July 5, 2020."You’ll soar through the air on adrenaline-pumping carnival rides, strike a power pose with your favorite superheroes, taste your way through the Fair’s superfoods, discover entertainment surprises around every corner, learn the science and history of being a superhero and meet real-life community heroes who put Clark Kent to shame," the fair's website reads.RELATED:Carlsbad Strawberry Field and Pumpkin Patch holds decades of family historyMission Hills home transformed into whimsical topiary gardenLa Jolla taco stand named among America's best fast-casual restaurantsAs hinted in the description, the fair is also looking for locals to nominate community heroes who will be honored throughout the fair's run. Nominations can be submitted here.The fair's exhibits will also likely take a superhero slant, as guests learn the "science and history" behind superheroes. And where better to learn than the home of San Diego Comic-Con?And, of course, themed foods are sure to make an appearance from vendors like Chicken Charlie, Bacon-A-Fair, and Pink's Hot Dogs.Before the year is even up, the fair is also offering discounts on admission, attractions, and parking. For more information on the fair, performers, and attractions, visit sdfair.com. 1488

SAN DIEGO (KGTV) -- If you’re looking for something to do the Friday after Thanksgiving but don’t want to get caught in the Black Friday crowds, county parks is offering an alternative known as Green Friday On Friday, November 23, parking fees will be waived at all county parks and preserves, according to County of San Diego Parks and Recreation. Click here for more information on the free parking. Normally, visitors are charged per vehicle, per day. Check out the list below for more Green Friday offers from the county: 546

SAN DIEGO (KGTV) -- Just days before masses of people are expected to descend on Del Mar for the San Diego County Fair, a busy road has reopened following a bluff collapse. City crews completed a retaining wall and reopened Jimmy Durante Boulevard Wednesday afternoon. The road wasn't originally expected to reopen until June 4, several days after the fair opens on May 31. RELATED: What to know for the San Diego County FairThe northbound lanes of Jimmy Durante Boulevard closed in late April after part of a bluff collapsed. The cost of cleanup and stabilizing the cliff is expected to cost million. At a meeting in May, the city council voted to declare a local emergency, allowing the city to qualify for federal emergency funds. 745

SAN DIEGO (KGTV) - Looking for laughs? How about a week's worth of them?From May 24 to June 3, comedians will take deliver laughs during the 5th Annual San Diego Comedy Festival. From local comedians to those currently traveling the globe, profession funny men and women will showcase their talents and compete for prizes.Tickets range from to a VIP pass for 5 for shows at The Comedy Palace, The Lot, Comedy Heights, and other local venues.RELATED: Broadway performances heading to San Diego stages this yearThis year's lineup of comedic talents includes Marc Price, of 80s sitcom "Family Ties" fame, and Roger Kabler, who will headline a special tribute performance as the late comedy icon Robin Williams. A full list of comedians is available online.A variety of shows are on deck as well, from an all-Spanish show to a clean comedy showcase. Comedy fans can also check out improv comedy and workshops. And 80 comedians from across the country will compete for cash in standup showdowns. 1030

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