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SAN DIEGO (KGTV) — UC San Diego researchers are testing a technology that's been in development for more than a decade to fight the coronavirus.In lab experiments, "nanosponges" covered in human lung cell membranes and immune cell membranes were found to attract and neutralize the SARS-CoV-2 virus in cell culture, according to a UCSD release. This caused the virus to lose about 90% of infectivity, or its ability to hijack cells and reproduce.The tiny sponges are designed to impersonate and protect healthy cells by soaking up harmful pathogens and toxins, according to Liangfang Zhang, a nanoengineering professor at the UC San Diego Jacobs School of Engineering. RELATED: San Diego company's COVID-19 test gets emergency approvalFor example, the nanoparticle covered in membranes from cell types the virus is known to invade latch on to the virus. This prevent the virus from then entering an actual human cell."Traditionally, drug developers for infectious diseases dive deep on the details of the pathogen in order to find druggable targets. Our approach is different. We only need to know what the target cells are. And then we aim to protect the targets by creating biomimetic decoys," said Zhang.While Zhang has spent the last 10 years developing the technology, his lab turned to using the nano-particle to fight the coronavirus when the pandemic hit.RELATED: Scripps Research's antibodies study shows signs of success against coronavirusNow, the first data on the technology's ability to battle the virus is being released after testing by researchers at Boston University."Another interesting aspect of our approach is that even as SARS-CoV-2 mutates, as long as the virus can still invade the cells we are mimicking, our nanosponge approach should still work. I’m not sure this can be said for some of the vaccines and therapeutics that are currently being developed," said Zhang.UCSD researchers will test the nanosponges’ effectiveness in animal models in the next few months and are moving as fast as possible to eventually test the technology in humans. RELATED: Startup creates mobile COVID-19 testing clinic on wheelsNanosponges have a massive amount of testing ahead before they make it to human tests, Zhang said."I see potential for a preventive treatment, for a therapeutic that could be given early because once the nanosponges get in the lung, they can stay in the lung for some time," Zhang said. "If a virus comes, it could be blocked if there are nanosponges waiting for it."(Read more about the study and nanosponges here.) 2562

SAN DIEGO (KGTV) -- With indoor dining shutdown, local restaurants are relying on takeout orders to stay afloat.Curbside pick-up, with a holiday flair, has been the specialty of the house at Parc Bistro and Brasserie in Bankers Hill. The service has also helped the eatery stay alive. In true holiday spirit, customers will see Santa and his Christmas elves deliver their food right to their car."If we could just dress up a little bit, and feel good about it, we can spread that positive energy in these tough times," says restaurant general manager Samantha Scholl.Scholl calls the last nine months devastating and an emotional roller coaster. She had to layoff close to 30 of her staff since March "We've had to pivot and change, and then we had to shut down and re-open. But we are grateful because we've had such strong support from our community," said Scholl.And since there is no dining in, Parc Bistro is offering curbside holiday packages, of which they have sold out all 250."The community has been behind us since the beginning and especially this last year which has been incredibly tough," Scholl says.The community has been behind Parc Bistro, and Scholl has been behind her staff. "I did another holiday relief fund through GoFundMe. My goal is to raise ,000 and I'm at about ,000 right now. Also, all of the gratuities we receive from guests from our holiday takeout is dispersed equally among all our staff," she says.But while Christmas packages are all sold out, Scholl says you can still get your New Year's Eve order in. "You have to have our beef Bourguignon it's a French classic," Scholl said. 1634

SAN DIEGO (KGTV) - Whether you're looking to eat, drink, or stroll around San Diego this weekend, there's an event just for you.Mission Beach will celebrate is delicious culinary scene Thursday in its annual Taste of Mission Beach event, benefiting clean beaches.Still hungry? San Diego Taco Fest heads to town Saturday for some delicious fun, live music, and Lucha Libre action in Waterfront Park.Don't see anything interesting? Check our 10News event calendar for even more local happenings!Pirates will take over the San Diego Maritime Museum for a two-day celebration of the seven seas, and cowboys and cowgirls will saddle up in Ramona for some rodeo fun:THURSDAY5th Annual Taste of Mission BeachWhere: Various restaurants; Cost: Mission Beach invites foodies to walk, ride, or sail to as many Mission Beach restaurants and sample their delicious eats during Taste of Mission Beach. Proceeds from the event benefit the Pacific Beach Street Guardians, which works to keep beach communities clean. Encinitas Cruise NightsWhere: Downtown Encinitas; Cost: FreeDowntown Encinitas will be hopping with the sounds of rock n' roll against a backdrop of muscle, hot rod, and classic cars from D St. to K St. Check out historic vehicles from local owners, enjoy live music, and stick around to see whose rides win some awards or grab some dinner on Highway 101. 1397

SAN DIEGO (KGTV)- Across California, many businesses continue to struggle in San Diego County, and some business owners say they can’t afford to pay their rent anymore without their usual income during this pandemic.Landlords are also feeling the effects of the small business struggle.“Many tenants are paying their rents, there aren’t many tenants paying their rents from profits,” said Sandy Sigal, CEO of NewMark Merrill Companies. “We’re not going to make any money or have any profits this year at all, we know that, but we do need enough money to pay our mortgages and lenders.NewMark Merrill Companies own about 80 shopping centers in three states, including California. They own 12 shopping centers in San Diego County, from Oceanside to Chula Vista.Sigal said many of his tenants had been hit hard during this pandemic, especially in California.“The category type that we’ve lost lots of tenants are the nail and hair salons, very often run by mom and pops,” he said.In San Diego County, the following seven tenants have closed their businesses permanently.Expedia – Terra Nova Plaza in Chula VistaSouplantation – Piazza Carmel in San DiegoSouplantation - Chula Vista Crossings in Chula VistaPronto Insurance – Tri-City Crossroads in OceansideElements Massage – Nordahl Marketplace in San MarcosShape Threading – Nordahl Marketplace in San MarcosKeller Williams – Rancho Bernardo Village in San Diego“We did what we could to help tenants where they needed it,” said Sigal. “If you’re a small restaurant and you had to close, you were closed for 3 to 4 months; we did what we could to help you, which included rent deferrals and helping you apply for those PPP loans. We bought tarps. We bought fans, and we bought artificial turf. We’re doing what we can.”But Sigal said landlords could only do so much, and it’s up to the government to step in and help save these businesses.“If there was a fire or earthquake or flood, they would have insurance for all this,” he said. “We need to extend what was PPP or The RESTART Act. I’m in favor of some stimulus to the unemployed.”Without additional assistance now, it’s a struggle he expects to continue until significant changes are made, and businesses can fully bounce back.“If the government helps my tenants, I’d be helped enough,” he said. “This is no one’s fault, but the pandemic and we all got to get through this together.” 2393

SAN DIEGO (KGTV) — Two tropical storms bearing down on the Eastern Pacific have forced a Norwegian Bliss cruise ship to abandon its original route and stop in San Diego.The stopover for the cruise ship came just before 7 a.m. Wednesday. The ship was originally scheduled to sail from Los Angeles to several ports in Mexico but was forced to change that route due to tropical storms Willa and Vicente.The new route has the cruise ship heading for San Francisco to San Diego to Ensenada, Mexico. The ship is scheduled to depart from San Diego at 6 p.m. Wednesday.Norwegian Cruise Line said in a statement that guests were alerted to the modified itinerary as soon as possible."Due to Hurricane Willa and Tropical Storm Vincente in the Eastern Pacific, we modified Norwegian Bliss’ itinerary from Los Angeles," the cruise line said. "Our onboard team is working to ensure the best vacation experience possible given these weather-related changes."Tropical storm Willa was downgraded from a Category 5 Hurricane Wednesday, but still made landfall with maximum sustained winds of 120 mph. Vicente was due to follow Willa moving inland over Mexico.RELATED: Cruise industry booming as season begins in San DiegoThe Norwegian Bliss is one of Norwegian Cruise Line's newest vessels in service. The ship can hold more than 4,000 guests, 1,700 crew members, and includes an aqua park, laser tag arena, casino, and a two-level race track — the first for a North American-based ship.Each port of call has an approximate 0,000 impact in San Diego, according to port officials. The port expects 92 ships to dock in San Diego this year, bringing more than 295,000 passengers to town. 1698

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